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Presenile dementia

MedGen UID:
8278
•Concept ID:
C0011265
•
Mental or Behavioral Dysfunction
Synonyms: Dementia, Presenile; Presenile Dementia
SNOMED CT: Presenile dementia (12348006)

Definition

The presence of dementia in an individual younger than age sixty five. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPresenile dementia

Professional guidelines

PubMed

Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Wong TH, Seelaar H, Melhem S, Rozemuller AJM, van Swieten JC
Neurobiol Aging 2020 Feb;86:201.e9-201.e14. Epub 2019 Jan 29 doi: 10.1016/j.neurobiolaging.2019.01.015. PMID: 30797548
Presenile dementia--etiology, clinical profile and treatment response at four month follow up.
Sundar U, Sharma A, Yeolekar ME
J Assoc Physicians India 2004 Dec;52:953-8. PMID: 15884451
Differential diagnosis of presenile dementia on clinical grounds.
Gustafson L, Nilsson L
Acta Psychiatr Scand 1982 Mar;65(3):194-209. doi: 10.1111/j.1600-0447.1982.tb00840.x. PMID: 7072512

Recent clinical studies

Etiology

COVID-19 and dementia: Analyses of risk, disparity, and outcomes from electronic health records in the US.
Wang Q, Davis PB, Gurney ME, Xu R
Alzheimers Dement 2021 Aug;17(8):1297-1306. Epub 2021 Feb 9 doi: 10.1002/alz.12296. PMID: 33559975Free PMC Article
Vascular cognitive impairment: A preventable component of dementia.
Azarpazhooh MR, Hachinski V
Handb Clin Neurol 2019;167:377-391. doi: 10.1016/B978-0-12-804766-8.00020-0. PMID: 31753144
Alzheimer Disease: Scientific Breakthroughs and Translational Challenges.
Caselli RJ, Beach TG, Knopman DS, Graff-Radford NR
Mayo Clin Proc 2017 Jun;92(6):978-994. doi: 10.1016/j.mayocp.2017.02.011. PMID: 28578785Free PMC Article
Rapidly progressive young-onset dementias: neuropsychiatric aspects.
Shrestha R, Wuerz T, Appleby BS
Psychiatr Clin North Am 2015 Jun;38(2):221-32. Epub 2015 Mar 2 doi: 10.1016/j.psc.2015.01.001. PMID: 25998112
Frontotemporal dementia--a brief review.
Sjögren M, Andersen C
Mech Ageing Dev 2006 Feb;127(2):180-7. Epub 2005 Dec 5 doi: 10.1016/j.mad.2005.09.015. PMID: 16330083

Diagnosis

Vascular cognitive impairment: A preventable component of dementia.
Azarpazhooh MR, Hachinski V
Handb Clin Neurol 2019;167:377-391. doi: 10.1016/B978-0-12-804766-8.00020-0. PMID: 31753144
Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
Rapidly progressive young-onset dementias: neuropsychiatric aspects.
Shrestha R, Wuerz T, Appleby BS
Psychiatr Clin North Am 2015 Jun;38(2):221-32. Epub 2015 Mar 2 doi: 10.1016/j.psc.2015.01.001. PMID: 25998112
Presenile dementia syndromes: an update on taxonomy and diagnosis.
Greicius MD, Geschwind MD, Miller BL
J Neurol Neurosurg Psychiatry 2002 Jun;72(6):691-700. doi: 10.1136/jnnp.72.6.691. PMID: 12023408Free PMC Article
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587

Therapy

Hashimoto's encephalopathy mimicking presenile dementia.
Goh KK, Chiu YH, Shen WW
Gen Hosp Psychiatry 2014 May-Jun;36(3):360.e9-11. Epub 2014 Jan 17 doi: 10.1016/j.genhosppsych.2014.01.006. PMID: 24559930
Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease.
Penberthy WT
Curr Drug Metab 2007 Apr;8(3):245-66. doi: 10.2174/138920007780362545. PMID: 17430113
Neuro-ocular Lyme borreliosis.
Smith JL
Neurol Clin 1991 Feb;9(1):35-53. PMID: 2011111
Organic solvents and presenile dementia (the painters' syndrome). A critical review of the Danish literature.
Errebo-Knudsen EO, Olsen F
Sci Total Environ 1986 Jan;48(1-2):45-67. doi: 10.1016/0048-9697(86)90153-1. PMID: 3511526
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587

Prognosis

Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
Presenile dementia syndromes: an update on taxonomy and diagnosis.
Greicius MD, Geschwind MD, Miller BL
J Neurol Neurosurg Psychiatry 2002 Jun;72(6):691-700. doi: 10.1136/jnnp.72.6.691. PMID: 12023408Free PMC Article
Utility of auditory P300 in detection of presenile dementia.
Filipović SR, Kostić VS
J Neurol Sci 1995 Aug;131(2):150-5. doi: 10.1016/0022-510x(95)00093-h. PMID: 7595640
Presenile dementia with motor neuron disease.
Mitsuyama Y
Dementia 1993 May-Aug;4(3-4):137-42. doi: 10.1159/000107312. PMID: 8401781
Steroid-sensitive dementia.
Paulson GW
Am J Psychiatry 1983 Aug;140(8):1031-3. doi: 10.1176/ajp.140.8.1031. PMID: 6869587

Clinical prediction guides

Genetic screening in early-onset Alzheimer's disease identified three novel presenilin mutations.
Wong TH, Seelaar H, Melhem S, Rozemuller AJM, van Swieten JC
Neurobiol Aging 2020 Feb;86:201.e9-201.e14. Epub 2019 Jan 29 doi: 10.1016/j.neurobiolaging.2019.01.015. PMID: 30797548
Clinical and Imaging Characteristics Associated with Color Vision Impairment in Lewy Body Disease.
Unger RH, Flanigan PM, Khosravi M, Leverenz JB, Tousi B
J Alzheimers Dis 2019;72(4):1233-1240. doi: 10.3233/JAD-190727. PMID: 31683482
Imaging and fluid biomarkers in frontotemporal dementia.
Meeter LH, Kaat LD, Rohrer JD, van Swieten JC
Nat Rev Neurol 2017 Jul;13(7):406-419. Epub 2017 Jun 16 doi: 10.1038/nrneurol.2017.75. PMID: 28621768
The enigmatic function of TREM-2 in osteoclastogenesis.
Colonna M, Turnbull I, Klesney-Tait J
Adv Exp Med Biol 2007;602:97-105. doi: 10.1007/978-0-387-72009-8_13. PMID: 17966394
The clinical phenomenology of presenile dementia. A critical review of the literature.
Liston EH
J Nerv Ment Dis 1979 Jun;167(6):329-36. doi: 10.1097/00005053-197906000-00001. PMID: 376780

Recent systematic reviews

The role of brain perfusion SPECT in the diagnosis of frontotemporal dementia: A systematic review.
Athanasio BS, Oliveira ACS, Pedrosa AL, Borges RS, Neto AOM, Oliveira RA, de Resende EPF, de Moraes RF, Caramelli P, de Souza LC
J Neuroimaging 2024 May-Jun;34(3):308-319. Epub 2024 Jan 8 doi: 10.1111/jon.13189. PMID: 38192155

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