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Iris nevus

MedGen UID:
83423
•Concept ID:
C0346376
•
Neoplastic Process
Synonyms: Benign melanoma of iris; Eye freckle; Iris Nevus; Nevus of iris; Nevus of Iris; Nevus of the Iris
SNOMED CT: Benign melanoma of iris (95711003); Nevus of iris (95711003); Iris nevus (95711003)
 
HPO: HP:0011525

Definition

A benign brown pigmented area over the iris representing proliferation of melanocyte cells in the stromal layer of the iris. An iris nevus can be flat or occasionally slightly elevated. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIris nevus

Professional guidelines

PubMed

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
The differential diagnosis of malignant melanoma of the iris. A clinical study of 200 patients.
Shields JA, Sanborn GE, Augsburger JJ
Ophthalmology 1983 Jun;90(6):716-20. doi: 10.1016/s0161-6420(83)34500-0. PMID: 6888862

Recent clinical studies

Etiology

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Findings of ocular examinations in healthy full-term newborns.
Yenice EK, Petriçli İS, Kara C
Arq Bras Oftalmol 2022;87(1):0536. Epub 2022 Jul 18 doi: 10.5935/0004-2749.2021-0536. PMID: 35857993
Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes.
Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Melanoma of the eye: revealing hidden secrets, one at a time.
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938
New insights into oculodermal nevogenesis and proposal for a new iris nevus classification.
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901

Diagnosis

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Iris melanocytoma and secondary glaucoma.
Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Cysts of the Iris Pigment Epithelium. What Is New and Interesting? The 2016 Jose Rizal International Medal Lecture.
Shields JA, Shields CL
Asia Pac J Ophthalmol (Phila) 2017 Jan-Feb;6(1):64-69. doi: 10.22608/APO.201613. PMID: 28161919
Nevoid iris melanoma, case report.
Saldaña-Garrido JD, Martínez-Hergueta MC, Martínez-Rubio MM
Arch Soc Esp Oftalmol 2017 Jul;92(7):347-350. Epub 2016 Jun 1 doi: 10.1016/j.oftal.2016.04.005. PMID: 27262610
Diffuse iris nevus.
Mahdavi Fard A, Pourafkari L, Nader ND
QJM 2016 Feb;109(2):137. Epub 2015 Oct 1 doi: 10.1093/qjmed/hcv169. PMID: 26428339

Therapy

Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes.
Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Malignant transformation of multifocal tapioca iris nevus in a child.
Harley MR, Rao R, Lally SE, Shields CL
J AAPOS 2017 Aug;21(4):340-342. Epub 2017 Jun 16 doi: 10.1016/j.jaapos.2017.06.007. PMID: 28630029
New insights into oculodermal nevogenesis and proposal for a new iris nevus classification.
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901
Clinical and histopathologic findings of iris nevus (Cogan-Reese) syndrome.
Ozdemir Y, Onder F, Coşar CB, Usubütün A, Kural G
Acta Ophthalmol Scand 1999 Apr;77(2):234-7. doi: 10.1034/j.1600-0420.1999.770226.x. PMID: 10321548

Prognosis

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Population-based incidence of intraocular tumours in Olmsted County, Minnesota.
Oyemade KA, Xu TT, Lopez Dominguez J, Dumbrava MG, Hodge DO, White LJ, Dalvin LA
Br J Ophthalmol 2023 Sep;107(9):1369-1376. Epub 2022 Apr 21 doi: 10.1136/bjophthalmol-2021-320682. PMID: 35450938Free PMC Article
Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes.
Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Iris melanocytoma and secondary glaucoma.
Xavier C, Hipolito-Fernandes D, Cardigos J, Magriço A
BMJ Case Rep 2020 Dec 13;13(12) doi: 10.1136/bcr-2020-237269. PMID: 33318246Free PMC Article
Melanoma of the eye: revealing hidden secrets, one at a time.
Shields CL, Kels JG, Shields JA
Clin Dermatol 2015 Mar-Apr;33(2):183-96. Epub 2015 Jan 14 doi: 10.1016/j.clindermatol.2014.10.010. PMID: 25704938

Clinical prediction guides

Iris melanoma: Review of clinical features, risks, management, and outcomes.
Cherkas E, Kalafatis NE, Marous MR, Shields CL
Clin Dermatol 2024 Jan-Feb;42(1):62-70. Epub 2023 Oct 21 doi: 10.1016/j.clindermatol.2023.10.009. PMID: 37865279
Photoablative cosmetic iridoplasty: effective, safe, and predictable-eye color change in 1176 eyes.
Grimaldos Ruiz P
Int Ophthalmol 2021 Apr;41(4):1381-1393. Epub 2021 Jan 23 doi: 10.1007/s10792-021-01693-5. PMID: 33484383Free PMC Article
Cysts of the Iris Pigment Epithelium. What Is New and Interesting? The 2016 Jose Rizal International Medal Lecture.
Shields JA, Shields CL
Asia Pac J Ophthalmol (Phila) 2017 Jan-Feb;6(1):64-69. doi: 10.22608/APO.201613. PMID: 28161919
Nevoid iris melanoma, case report.
Saldaña-Garrido JD, Martínez-Hergueta MC, Martínez-Rubio MM
Arch Soc Esp Oftalmol 2017 Jul;92(7):347-350. Epub 2016 Jun 1 doi: 10.1016/j.oftal.2016.04.005. PMID: 27262610
New insights into oculodermal nevogenesis and proposal for a new iris nevus classification.
Schwab C, Zalaudek I, Mayer C, Riedl R, Wackernagel W, Juch H, Aigner B, Brunasso AM, Langmann G, Richtig E
Br J Ophthalmol 2015 May;99(5):644-9. Epub 2014 Oct 30 doi: 10.1136/bjophthalmol-2014-305849. PMID: 25359901

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