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Neonatal alloimmune thrombocytopenia

MedGen UID:
840004
•Concept ID:
C3853779
•
Disease or Syndrome
Synonyms: Alloimmune Thrombocytopenia, Neonatal; Alloimmune Thrombocytopenias, Neonatal; Neonatal Alloimmune Thrombocytopenia; Neonatal Alloimmune Thrombocytopenias; Neonatal Thrombocytopenia; Neonatal Thrombocytopenias; Thrombocytopenia, Neonatal; Thrombocytopenia, Neonatal Alloimmune; Thrombocytopenias, Neonatal; Thrombocytopenias, Neonatal Alloimmune
SNOMED CT: Neonatal alloimmune thrombocytopenia (240305000); Isoimmune neonatal thrombocytopenia (240305000); Alloimmune neonatal thrombocytopenia (240305000); Neonatal thrombocytopenia due to platelet alloimmunization (240305000); NAIT - neonatal alloimmune thrombocytopenia (240305000)
 
HPO: HP:0004809

Definition

Low platelet count associated with maternal platelet-specific alloantibodies. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeonatal alloimmune thrombocytopenia

Professional guidelines

PubMed

How I diagnose and treat neonatal thrombocytopenia.
Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Neonatal thrombocytopenia: A review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia.
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
ACOG Practice Bulletin No. 207: Thrombocytopenia in Pregnancy.
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Recent clinical studies

Etiology

Immune-Mediated Neonatal Thrombocytopenia.
Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
New developments in fetal and neonatal alloimmune thrombocytopenia.
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Neonatal Alloimmune Thrombocytopenia: A Concise Review.
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
Foetal and neonatal alloimmune thrombocytopenia.
Winkelhorst D, Oepkes D
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:15-27. Epub 2019 Feb 6 doi: 10.1016/j.bpobgyn.2019.01.017. PMID: 30827816
ACOG Practice Bulletin No. 207: Thrombocytopenia in Pregnancy.
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Diagnosis

How I diagnose and treat neonatal thrombocytopenia.
Stanworth SJ, Mumford AD
Blood 2023 Jun 1;141(22):2685-2697. doi: 10.1182/blood.2022018017. PMID: 36787503
Neonatal thrombocytopenia: A review. I. Definitions, differential diagnosis, causes, immune thrombocytopenia.
Donato H
Arch Argent Pediatr 2021 Jun;119(3):e202-e214. doi: 10.5546/aap.2021.eng.e202. PMID: 34033425
New developments in fetal and neonatal alloimmune thrombocytopenia.
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Neonatal Alloimmune Thrombocytopenia: A Concise Review.
Norton T, Newberry D, Jnah A
Adv Neonatal Care 2021 Apr 1;21(2):115-121. doi: 10.1097/ANC.0000000000000775. PMID: 32657948
ACOG Practice Bulletin No. 207: Thrombocytopenia in Pregnancy.
Obstet Gynecol 2019 Mar;133(3):e181-e193. doi: 10.1097/AOG.0000000000003100. PMID: 30801473

Therapy

Immune-Mediated Neonatal Thrombocytopenia.
Batton E, Leibel SL
Neoreviews 2022 Jul 1;23(7):e462-e471. doi: 10.1542/neo.23-7-e462. PMID: 35773506
New developments in fetal and neonatal alloimmune thrombocytopenia.
Bussel JB, Vander Haar EL, Berkowitz RL
Am J Obstet Gynecol 2021 Aug;225(2):120-127. Epub 2021 Apr 8 doi: 10.1016/j.ajog.2021.04.211. PMID: 33839095
Foetal and neonatal alloimmune thrombocytopenia.
Winkelhorst D, Oepkes D
Best Pract Res Clin Obstet Gynaecol 2019 Jul;58:15-27. Epub 2019 Feb 6 doi: 10.1016/j.bpobgyn.2019.01.017. PMID: 30827816
Fetal/neonatal alloimmune thrombocytopenia.
Sachs UJ
Thromb Res 2013 Jan;131 Suppl 1:S42-6. doi: 10.1016/S0049-3848(13)70020-3. PMID: 23452741
Alloimmune thrombocytopenias.
Salama A
J Pediatr Hematol Oncol 2003 Dec;25 Suppl 1:S39-41. doi: 10.1097/00043426-200312001-00009. PMID: 14668638

Prognosis

Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia.
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Postnatal treatment for children with fetal and neonatal alloimmune thrombocytopenia: a multicentre, retrospective, cohort study.
de Vos TW, Winkelhorst D, Árnadóttir V, van der Bom JG, Canals Surís C, Caram-Deelder C, Deschmann E, Haysom HE, Hverven HBC, Lozar Krivec J, McQuilten ZK, Muñiz-Diaz E, Nogués N, Oepkes D, Porcelijn L, van der Schoot CE, Saxonhouse M, Sola-Visner M, Tiblad E, Tiller H, Wood EM, Young V, Železnik M, de Haas M, Lopriore E
Lancet Haematol 2022 Nov;9(11):e844-e853. Epub 2022 Sep 12 doi: 10.1016/S2352-3026(22)00243-5. PMID: 36108655
Diagnosis and management of neonatal thrombocytopenia.
Holzhauer S, Zieger B
Semin Fetal Neonatal Med 2011 Dec;16(6):305-10. Epub 2011 Aug 10 doi: 10.1016/j.siny.2011.07.008. PMID: 21835709
Diagnosis and management of neonatal alloimmune thrombocytopenia.
Arnold DM, Smith JW, Kelton JG
Transfus Med Rev 2008 Oct;22(4):255-67. doi: 10.1016/j.tmrv.2008.05.003. PMID: 18848153
Fetal thrombocytopenia.
Porcelijn L, Van den Akker ES, Oepkes D
Semin Fetal Neonatal Med 2008 Aug;13(4):223-30. Epub 2008 Apr 8 doi: 10.1016/j.siny.2008.02.008. PMID: 18400574

Clinical prediction guides

Immune thrombocytopenia and pregnancy: an exposed/nonexposed cohort study.
Guillet S, Loustau V, Boutin E, Zarour A, Comont T, Souchaud-Debouverie O, Costedoat Chalumeau N, Pan-Petesch B, Gobert D, Cheze S, Viallard JF, Morin AS, Sauvetre G, Cliquennois M, Royer B, Masseau A, Terriou L, Fieschi C, Lambotte O, Girault S, Lioger B, Audia S, Sacre K, Lega JC, Langlois V, Benachi A, Orvain C, Devidas A, Humbert S, Gambier N, Ruivard M, Zarrouk V, Ebbo M, Willems L, Segaux L, Mahevas M, Haddad B, Michel M, Canoui-Poitrine F, Godeau B
Blood 2023 Jan 5;141(1):11-21. doi: 10.1182/blood.2022017277. PMID: 36054922Free PMC Article
Clinical and laboratory predictors of fetal and neonatal alloimmune thrombocytopenia.
Matusiak K, Patriquin CJ, Deniz S, Dzaja N, Smith JW, Wang G, Nazy I, Kelton JG, Arnold DM
Transfusion 2022 Nov;62(11):2213-2222. Epub 2022 Oct 14 doi: 10.1111/trf.17144. PMID: 36239096
Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study.
de Vos TW, Winkelhorst D, Baelde HJ, Dijkstra KL, van Bergen RDM, van der Meeren LE, Nikkels PGJ, Porcelijn L, van der Schoot CE, Vidarsson G, Eikmans M, Kapur R, van der Keur C, Trouw LA, Oepkes D, Lopriore E, van der Hoorn MP, Bos M, de Haas M
Int J Mol Sci 2021 Jun 23;22(13) doi: 10.3390/ijms22136763. PMID: 34201864Free PMC Article
Fetal/Neonatal Alloimmune Thrombocytopenia: Pathogenesis, Diagnostics and Prevention.
Brojer E, Husebekk A, Dębska M, Uhrynowska M, Guz K, Orzińska A, Dębski R, Maślanka K
Arch Immunol Ther Exp (Warsz) 2016 Aug;64(4):279-90. Epub 2015 Nov 12 doi: 10.1007/s00005-015-0371-9. PMID: 26564154Free PMC Article
Diagnosis and management of neonatal alloimmune thrombocytopenia.
Arnold DM, Smith JW, Kelton JG
Transfus Med Rev 2008 Oct;22(4):255-67. doi: 10.1016/j.tmrv.2008.05.003. PMID: 18848153

Recent systematic reviews

Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome.
Kjeldsen-Kragh J, Fergusson DA, Kjaer M, Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia HF, Landry D, Shehata N
Blood Adv 2020 Jul 28;4(14):3368-3377. doi: 10.1182/bloodadvances.2020002137. PMID: 32717028Free PMC Article
Fetal and neonatal alloimmune thrombocytopenia: recommendations for evidence-based practice, an international approach.
Lieberman L, Greinacher A, Murphy MF, Bussel J, Bakchoul T, Corke S, Kjaer M, Kjeldsen-Kragh J, Bertrand G, Oepkes D, Baker JM, Hume H, Massey E, Kaplan C, Arnold DM, Baidya S, Ryan G, Savoia H, Landry D, Shehata N; International Collaboration for Transfusion Medicine Guidelines (ICTMG)
Br J Haematol 2019 May;185(3):549-562. Epub 2019 Mar 3 doi: 10.1111/bjh.15813. PMID: 30828796
Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review.
Winkelhorst D, Murphy MF, Greinacher A, Shehata N, Bakchoul T, Massey E, Baker J, Lieberman L, Tanael S, Hume H, Arnold DM, Baidya S, Bertrand G, Bussel J, Kjaer M, Kaplan C, Kjeldsen-Kragh J, Oepkes D, Ryan G
Blood 2017 Mar 16;129(11):1538-1547. Epub 2017 Jan 27 doi: 10.1182/blood-2016-10-739656. PMID: 28130210
Incidence and consequences of neonatal alloimmune thrombocytopenia: a systematic review.
Kamphuis MM, Paridaans NP, Porcelijn L, Lopriore E, Oepkes D
Pediatrics 2014 Apr;133(4):715-21. Epub 2014 Mar 3 doi: 10.1542/peds.2013-3320. PMID: 24590747
Screening in pregnancy for fetal or neonatal alloimmune thrombocytopenia: systematic review.
Kamphuis MM, Paridaans N, Porcelijn L, De Haas M, Van Der Schoot CE, Brand A, Bonsel GJ, Oepkes D
BJOG 2010 Oct;117(11):1335-43. doi: 10.1111/j.1471-0528.2010.02657.x. PMID: 20618318

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