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Severe acute respiratory infection

MedGen UID:
840477
•Concept ID:
C3873497
•
Disease or Syndrome
Synonyms: Severe Acute Respiratory Infection; Severe acute respiratory infection (SARI)
SNOMED CT: Severe acute respiratory infection (SARI) (707224005); Severe acute respiratory infection (707224005)

Definition

A respiratory infectious disorder that leads to an acute illness that requires medical attention. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSevere acute respiratory infection

Professional guidelines

PubMed

Management of Severe Influenza.
O'Driscoll LS, Martin-Loeches I
Semin Respir Crit Care Med 2021 Dec;42(6):771-787. Epub 2021 Dec 16 doi: 10.1055/s-0041-1735491. PMID: 34918320
Monitoring of human coronaviruses in Belgian primary care and hospitals, 2015-20: a surveillance study.
Fischer N, Dauby N, Bossuyt N, Reynders M, Gérard M, Lacor P, Daelemans S, Lissoir B, Holemans X, Magerman K, Jouck D, Bourgeois M, Delaere B, Quoilin S, Van Gucht S, Thomas I, Barbezange C, Subissi L
Lancet Microbe 2021 Mar;2(3):e105-e114. Epub 2021 Jan 27 doi: 10.1016/S2666-5247(20)30221-4. PMID: 33937883Free PMC Article
Preparedness and Best Practice in Radiology Department for COVID-19 and Other Future Pandemics of Severe Acute Respiratory Infection.
Wan YL, Schoepf UJ, Wu CC, Giovagnoli DP, Wu MT, Hsu HH, Chang YC, Yang CT, Cherng WJ
J Thorac Imaging 2020 Jul;35(4):239-245. doi: 10.1097/RTI.0000000000000529. PMID: 32384412

Recent clinical studies

Etiology

Atmospheric environment and severe acute respiratory infections in Nanjing, China, 2018-2019.
Wu KJ, Wu XQ, Hong L
Int J Environ Health Res 2023 May;33(5):441-451. Epub 2022 Feb 7 doi: 10.1080/09603123.2022.2034757. PMID: 35130812
Leveraging International Influenza Surveillance Systems and Programs during the COVID-19 Pandemic.
Marcenac P, McCarron M, Davis W, Igboh LS, Mott JA, Lafond KE, Zhou W, Sorrells M, Charles MD, Gould P, Arriola CS, Veguilla V, Guthrie E, Dugan VG, Kondor R, Gogstad E, Uyeki TM, Olsen SJ, Emukule GO, Saha S, Greene C, Bresee JS, Barnes J, Wentworth DE, Fry AM, Jernigan DB, Azziz-Baumgartner E
Emerg Infect Dis 2022 Dec;28(13):S26-S33. doi: 10.3201/eid2813.212248. PMID: 36502434Free PMC Article
Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV.
Pecego AC, Amâncio RT, Costa DM, Bozza FA, Siqueira MM, Oliveira ML, Cerbino-Neto J, Japiassu A
Int J STD AIDS 2020 Feb;31(2):100-108. Epub 2020 Jan 22 doi: 10.1177/0956462419882587. PMID: 31969059Free PMC Article
Epidemiology of Severe Acute Respiratory Infection (SARI) Cases at a sentinel site in Egypt, 2013-15.
Elhakim MM, Kandil SK, Abd Elaziz KM, Anwar WA
J Public Health (Oxf) 2020 Aug 18;42(3):525-533. doi: 10.1093/pubmed/fdz053. PMID: 31090911Free PMC Article
Severe acute respiratory infection surveillance in Montenegro, 2014-2017.
Rakocevic B, Grgurevic A, Trajkovic G, Pavlovic V, Sipetic Grujicic S, Vujosevic D, Medenica S, Vratnica Z, Bojovic O, Mugosa B
Curr Med Res Opin 2018 Aug;34(8):1513-1517. Epub 2018 May 15 doi: 10.1080/03007995.2018.1472558. PMID: 29723077

Diagnosis

Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period.
Regina Malveste Ito C, Santos MO, de Oliveira Cunha M, de Araújo KM, de Souza GRL, Rézio GS, de Brito PN, Rezende APC, Fonseca JG, Wastowski IJ, Gonçalves Vieira JD, Gomes Avelino MA, Carneiro LC
Virulence 2024 Dec;15(1):2310873. Epub 2024 Feb 21 doi: 10.1080/21505594.2024.2310873. PMID: 38384141Free PMC Article
Establishing severe acute respiratory infection (SARI) surveillance in a sentinel hospital, Ireland, 2021 to 2022.
Brady M, Duffy R, Domegan L, Salmon A, Maharjan B, O'Broin C, Bennett C, Christle J, Connell J, Feeney L, Nurdin N, Mallon P, Doran P, McNamara R, O'Grady S, McDermott S, Petty-Saphon N, O'Donnell J
Euro Surveill 2023 Jun;28(23) doi: 10.2807/1560-7917.ES.2023.28.23.2200740. PMID: 37289427Free PMC Article
Rhinovirus and metapneumovirus in patients with severe acute respiratory infection.
Lerman AS, Navarro Albarracín LF, Figari AB, Macías Lainez V, Uez OC
Arch Argent Pediatr 2023 Jun 1;121(3):e202202605. Epub 2022 Dec 1 doi: 10.5546/aap.2022-02605.eng. PMID: 36445064
Management of Severe Influenza.
O'Driscoll LS, Martin-Loeches I
Semin Respir Crit Care Med 2021 Dec;42(6):771-787. Epub 2021 Dec 16 doi: 10.1055/s-0041-1735491. PMID: 34918320
Etiologies of severe acute respiratory infection (SARI) and misdiagnosis of influenza in Indonesia, 2013-2016.
Aman AT, Wibawa T, Kosasih H, Asdie RH, Safitri I, Intansari US, Mawarti Y, Sudarmono P, Arif M, Puspitasari D, Alisjahbana B, Parwati KTM, Gasem MH, Lokida D, Lukman N, Hartono TS, Mardian Y, Liang CJ, Siddiqui S, Karyana M, Lau CY
Influenza Other Respir Viruses 2021 Jan;15(1):34-44. Epub 2020 Jul 14 doi: 10.1111/irv.12781. PMID: 32666619Free PMC Article

Therapy

Atmospheric environment and severe acute respiratory infections in Nanjing, China, 2018-2019.
Wu KJ, Wu XQ, Hong L
Int J Environ Health Res 2023 May;33(5):441-451. Epub 2022 Feb 7 doi: 10.1080/09603123.2022.2034757. PMID: 35130812
Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study.
Li J, Song CL, Wang T, Ye YL, Du JR, Li SH, Zhu JM
PLoS One 2021;16(3):e0248750. Epub 2021 Mar 22 doi: 10.1371/journal.pone.0248750. PMID: 33750952Free PMC Article
Mesenchymal Stem Cell Therapy for COVID-19: Present or Future.
Golchin A, Seyedjafari E, Ardeshirylajimi A
Stem Cell Rev Rep 2020 Jun;16(3):427-433. doi: 10.1007/s12015-020-09973-w. PMID: 32281052Free PMC Article
Severe morbidity among hospitalised adults with acute influenza and other respiratory infections: 2014-2015 and 2015-2016.
Segaloff HE, Petrie JG, Malosh RE, Cheng CK, McSpadden EJ, Ferdinands JM, Lamerato L, Lauring AS, Monto AS, Martin ET
Epidemiol Infect 2018 Aug;146(11):1350-1358. Epub 2018 Jun 8 doi: 10.1017/S0950268818001486. PMID: 29880077Free PMC Article
Progress on core outcome sets for critical care research.
Blackwood B, Marshall J, Rose L
Curr Opin Crit Care 2015 Oct;21(5):439-44. doi: 10.1097/MCC.0000000000000232. PMID: 26263299

Prognosis

Do children with severe acute respiratory infection need cohorting & isolation before screening for COVID-19?
Kumar R, Sah RR, Gupta A, Nallasamy K, Ghosh A, Verma S
Indian J Med Res 2022 May-Jun;155(5&6):491-495. doi: 10.4103/ijmr.ijmr_2557_21. PMID: 36348595Free PMC Article
High genotypic diversity of Rhinoviruses obtained from Tunisian children with severe acute respiratory infection.
Haddad-Boubaker S, Mefteh K, Mejri C, Bouaffsoun A, El Moussi A, Boutiba I, Mnif K, Slim A, Kechrid A, Smaoui H
J Infect Dev Ctries 2021 May 31;15(5):726-735. doi: 10.3855/jidc.12880. PMID: 34106898
Etiological and epidemiological characteristics of severe acute respiratory infection caused by multiple viruses and Mycoplasma pneumoniae in adult patients in Jinshan, Shanghai: A pilot hospital-based surveillance study.
Li J, Song CL, Wang T, Ye YL, Du JR, Li SH, Zhu JM
PLoS One 2021;16(3):e0248750. Epub 2021 Mar 22 doi: 10.1371/journal.pone.0248750. PMID: 33750952Free PMC Article
Viral causes of severe acute respiratory infection in hospitalized children and association with outcomes: A two-year prospective surveillance study in Suriname.
Juliana AE, Tang MJ, Kemps L, Noort AC, Hermelijn S, Plötz FB, Zonneveld R, Wilschut JC
PLoS One 2021;16(2):e0247000. Epub 2021 Feb 19 doi: 10.1371/journal.pone.0247000. PMID: 33606795Free PMC Article
Charlson comorbidity index scores and in-hospital prognosis of patients with severe acute respiratory infections.
Setter NW, Peres ML, de Almeida BMM, Petterle RR, Raboni SM
Intern Med J 2020 Jun;50(6):691-697. doi: 10.1111/imj.14398. PMID: 31180163

Clinical prediction guides

Rhinovirus infection and co-infection in children with severe acute respiratory infection during the COVID-19 pandemic period.
Regina Malveste Ito C, Santos MO, de Oliveira Cunha M, de Araújo KM, de Souza GRL, Rézio GS, de Brito PN, Rezende APC, Fonseca JG, Wastowski IJ, Gonçalves Vieira JD, Gomes Avelino MA, Carneiro LC
Virulence 2024 Dec;15(1):2310873. Epub 2024 Feb 21 doi: 10.1080/21505594.2024.2310873. PMID: 38384141Free PMC Article
Continuous evolution and emerging lineage of seasonal human coronaviruses: A multicenter surveillance study.
Ye RZ, Gong C, Cui XM, Liu JY, Fan H, Xie H, Wang Q, Ren ZY, Zhang YW, Xia LY, Zhang MZ, Li YY, Li ZH, Du LF, Zhang J, Cheng N, Shi W, Li MZ, Zhao L, Jiang JF, Jia N, Huang F, Cao WC
J Med Virol 2023 Jun;95(6):e28861. doi: 10.1002/jmv.28861. PMID: 37310144
Severe acute respiratory infection surveillance in Brazil: the role of public, private and philanthropic healthcare units.
Silva ADD, Veiga ABGD, Cruz OG, Bastos LS, Gomes MFDC
Health Policy Plan 2022 Oct 12;37(9):1075-1085. doi: 10.1093/heapol/czac050. PMID: 35766892Free PMC Article
Etiology, clinical, and epidemiological characteristics of severe respiratory infection in people living with HIV.
Pecego AC, Amâncio RT, Costa DM, Bozza FA, Siqueira MM, Oliveira ML, Cerbino-Neto J, Japiassu A
Int J STD AIDS 2020 Feb;31(2):100-108. Epub 2020 Jan 22 doi: 10.1177/0956462419882587. PMID: 31969059Free PMC Article
Severe Acute Respiratory Infection (SARI) sentinel surveillance in the country of Georgia, 2015-2017.
Chakhunashvili G, Wagner AL, Power LE, Janusz CB, Machablishvili A, Karseladze I, Tarkhan-Mouravi O, Zakhashvili K, Imnadze P, Gray GC, Anderson B, Boulton ML
PLoS One 2018;13(7):e0201497. Epub 2018 Jul 30 doi: 10.1371/journal.pone.0201497. PMID: 30059540Free PMC Article

Recent systematic reviews

Epidemiology of Human Metapneumovirus-associated Lower Respiratory Tract Infections in African Children: Systematic Review and Meta-analysis.
Ramocha LM, Mutsaerts EAML, Verwey C, Madhi S
Pediatr Infect Dis J 2021 May 1;40(5):479-485. doi: 10.1097/INF.0000000000003041. PMID: 33480663
Oxygen Therapy and Risk of Infection for Health Care Workers Caring for Patients With Viral Severe Acute Respiratory Infection: A Systematic Review and Meta-analysis.
Cournoyer A, Grand'Maison S, Lonergan AM, Lessard J, Chauny JM, Castonguay V, Marquis M, Frégeau A, Huard V, Garceau-Tremblay Z, Turcotte AS, Piette É, Paquet J, Cossette S, Féral-Pierssens AL, Leblanc RX, Martel V, Daoust R
Ann Emerg Med 2021 Jan;77(1):19-31. Epub 2020 Aug 10 doi: 10.1016/j.annemergmed.2020.06.037. PMID: 32788066Free PMC Article
Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis.
Santoso A, Pranata R, Wibowo A, Al-Farabi MJ, Huang I, Antariksa B
Am J Emerg Med 2021 Jun;44:352-357. Epub 2020 Apr 19 doi: 10.1016/j.ajem.2020.04.052. PMID: 32331955Free PMC Article
What Have We Learned About Middle East Respiratory Syndrome Coronavirus Emergence in Humans? A Systematic Literature Review.
Dawson P, Malik MR, Parvez F, Morse SS
Vector Borne Zoonotic Dis 2019 Mar;19(3):174-192. Epub 2019 Jan 24 doi: 10.1089/vbz.2017.2191. PMID: 30676269Free PMC Article
The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.
Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, Makki S, Rooney KD, Nguyen-Van-Tam JS, Beck CR; Convalescent Plasma Study Group
J Infect Dis 2015 Jan 1;211(1):80-90. Epub 2014 Jul 16 doi: 10.1093/infdis/jiu396. PMID: 25030060Free PMC Article

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