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Periventricular Hemorrhage of the Newborn

MedGen UID:
856233
•Concept ID:
C3896639
•
Finding

Definition

Bleeding into the brain tissue adjacent to the lateral cerebral ventricles of newborn infant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPeriventricular Hemorrhage of the Newborn

Professional guidelines

PubMed

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates.
Pammi M, Haque KN
Cochrane Database Syst Rev 2023 Jun 20;6(6):CD004205. doi: 10.1002/14651858.CD004205.pub4. PMID: 37338074Free PMC Article
Pharmacologic Prevention and Treatment of Neonatal Brain Injury.
McNally MA, Soul JS
Clin Perinatol 2019 Jun;46(2):311-325. Epub 2019 Mar 26 doi: 10.1016/j.clp.2019.02.006. PMID: 31010562
Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury.
Dunbar M, Kirton A
Lancet Child Adolesc Health 2018 Sep;2(9):666-676. Epub 2018 Jul 27 doi: 10.1016/S2352-4642(18)30173-1. PMID: 30119760

Recent clinical studies

Etiology

State-of-the-art neonatal cerebral ultrasound: technique and reporting.
Dudink J, Jeanne Steggerda S, Horsch S; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):3-12. doi: 10.1038/s41390-020-0776-y. PMID: 32218539Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants: a multicentre cohort study.
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
The Impact of Prematurity on Social and Emotional Development.
Leon Hernandez A
Clin Perinatol 2018 Sep;45(3):547-555. Epub 2018 Jul 2 doi: 10.1016/j.clp.2018.05.010. PMID: 30144854
Cerebellar injury in preterm infants.
Tam EWY
Handb Clin Neurol 2018;155:49-59. doi: 10.1016/B978-0-444-64189-2.00003-2. PMID: 29891076

Diagnosis

Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Rabe H, Gyte GM, Díaz-Rossello JL, Duley L
Cochrane Database Syst Rev 2019 Sep 17;9(9):CD003248. doi: 10.1002/14651858.CD003248.pub4. PMID: 31529790Free PMC Article
Perinatal stroke: mechanisms, management, and outcomes of early cerebrovascular brain injury.
Dunbar M, Kirton A
Lancet Child Adolesc Health 2018 Sep;2(9):666-676. Epub 2018 Jul 27 doi: 10.1016/S2352-4642(18)30173-1. PMID: 30119760
Periventricular-intraventricular hemorrhage.
Allan WC, Volpe JJ
Pediatr Clin North Am 1986 Feb;33(1):47-63. doi: 10.1016/s0031-3955(16)34969-0. PMID: 3513102

Therapy

Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Rabe H, Gyte GM, Díaz-Rossello JL, Duley L
Cochrane Database Syst Rev 2019 Sep 17;9(9):CD003248. doi: 10.1002/14651858.CD003248.pub4. PMID: 31529790Free PMC Article
Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes.
Novak CM, Ozen M, Burd I
Clin Perinatol 2018 Jun;45(2):357-375. Epub 2018 Mar 21 doi: 10.1016/j.clp.2018.01.015. PMID: 29747893
Volume-targeted versus pressure-limited ventilation in neonates.
Klingenberg C, Wheeler KI, McCallion N, Morley CJ, Davis PG
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD003666. doi: 10.1002/14651858.CD003666.pub4. PMID: 29039883Free PMC Article
Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.
Spittle A, Orton J, Anderson PJ, Boyd R, Doyle LW
Cochrane Database Syst Rev 2015 Nov 24;2015(11):CD005495. doi: 10.1002/14651858.CD005495.pub4. PMID: 26597166Free PMC Article
Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012.
Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, Laptook AR, Sánchez PJ, Van Meurs KP, Wyckoff M, Das A, Hale EC, Ball MB, Newman NS, Schibler K, Poindexter BB, Kennedy KA, Cotten CM, Watterberg KL, D'Angio CT, DeMauro SB, Truog WE, Devaskar U, Higgins RD; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
JAMA 2015 Sep 8;314(10):1039-51. doi: 10.1001/jama.2015.10244. PMID: 26348753Free PMC Article

Prognosis

The prognosis of refractory hypotension and severe intraventricular hemorrhage in very low birth weight infants.
Hwang-Bo S, Seo YM, Oh MY, Im SA, Youn YA
Medicine (Baltimore) 2022 Jul 29;101(30):e29598. doi: 10.1097/MD.0000000000029598. PMID: 35905281Free PMC Article
Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants: a multicentre cohort study.
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
Perinatal Brain Injury: Mechanisms, Prevention, and Outcomes.
Novak CM, Ozen M, Burd I
Clin Perinatol 2018 Jun;45(2):357-375. Epub 2018 Mar 21 doi: 10.1016/j.clp.2018.01.015. PMID: 29747893

Clinical prediction guides

Imaging of Premature Infants.
Locke A, Kanekar S
Clin Perinatol 2022 Sep;49(3):641-655. Epub 2022 Aug 22 doi: 10.1016/j.clp.2022.06.001. PMID: 36113927
Severity of Bronchopulmonary Dysplasia Among Very Preterm Infants in the United States.
Jensen EA, Edwards EM, Greenberg LT, Soll RF, Ehret DEY, Horbar JD
Pediatrics 2021 Jul;148(1) Epub 2021 Jun 2 doi: 10.1542/peds.2020-030007. PMID: 34078747Free PMC Article
Cranial ultrasound findings in preterm germinal matrix haemorrhage, sequelae and outcome.
Parodi A, Govaert P, Horsch S, Bravo MC, Ramenghi LA; eurUS.brain group
Pediatr Res 2020 Mar;87(Suppl 1):13-24. doi: 10.1038/s41390-020-0780-2. PMID: 32218535Free PMC Article
Neonatal care bundles are associated with a reduction in the incidence of intraventricular haemorrhage in preterm infants: a multicentre cohort study.
de Bijl-Marcus K, Brouwer AJ, De Vries LS, Groenendaal F, Wezel-Meijler GV
Arch Dis Child Fetal Neonatal Ed 2020 Jul;105(4):419-424. Epub 2019 Nov 15 doi: 10.1136/archdischild-2018-316692. PMID: 31732682
Periventricular leukomalacia.
Doran L
Neonatal Netw 1992 Jun;11(4):7-13. PMID: 1608381

Recent systematic reviews

Interventions to Reduce Severe Brain Injury Risk in Preterm Neonates: A Systematic Review and Meta-analysis.
Razak A, Patel W, Durrani NUR, Pullattayil AK
JAMA Netw Open 2023 Apr 3;6(4):e237473. doi: 10.1001/jamanetworkopen.2023.7473. PMID: 37052920Free PMC Article
Sound reduction management in the neonatal intensive care unit for preterm or very low birth weight infants.
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Rabe H, Gyte GM, Díaz-Rossello JL, Duley L
Cochrane Database Syst Rev 2019 Sep 17;9(9):CD003248. doi: 10.1002/14651858.CD003248.pub4. PMID: 31529790Free PMC Article
Volume-targeted versus pressure-limited ventilation in neonates.
Klingenberg C, Wheeler KI, McCallion N, Morley CJ, Davis PG
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD003666. doi: 10.1002/14651858.CD003666.pub4. PMID: 29039883Free PMC Article
Early developmental intervention programmes provided post hospital discharge to prevent motor and cognitive impairment in preterm infants.
Spittle A, Orton J, Anderson PJ, Boyd R, Doyle LW
Cochrane Database Syst Rev 2015 Nov 24;2015(11):CD005495. doi: 10.1002/14651858.CD005495.pub4. PMID: 26597166Free PMC Article

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