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Recurrent Pancreatic Neuroendocrine Carcinoma

MedGen UID:: 857326
•Concept ID:: C3897732
•: Neoplastic Process

Definition

The reemergence of pancreatic neuroendocrine carcinoma after a period of remission. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRecurrent Pancreatic Neuroendocrine Carcinoma

Disease
- Neoplasm
  - Epithelial neoplasm
    - Carcinoma
      - Adenocarcinoma
        Pancreatic endocrine carcinoma
        Recurrent Pancreatic Neuroendocrine Carcinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

Treatment strategies for neuroendocrine carcinoma of the upper digestive tract.

Morita M, Taguchi K, Kagawa M, Nakanoko T, Uehara H, Sugiyama M, Ota M, Ikebe M, Sugimachi K, Esaki T, Toh Y
Int J Clin Oncol 2020 May;25(5):842-850. Epub 2020 Feb 8 doi: 10.1007/s10147-020-01631-y. PMID: 32036480

Surgical management of pancreatic neuroendocrine tumors.

Kimura W, Tezuka K, Hirai I
Surg Today 2011 Oct;41(10):1332-43. Epub 2011 Sep 16 doi: 10.1007/s00595-011-4547-6. PMID: 21922354

See all (19)

Recent clinical studies

Etiology

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.

Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.

Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649 Free PMC Article

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

Everolimus.

Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763

Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.

Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025 Free PMC Article

See all (183)

Diagnosis

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807 Free PMC Article

Adult pancreatoblastoma: Current concepts in pathology.

Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617 Free PMC Article

Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.

Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025 Free PMC Article

Gastrinoma--morphological aspects.

Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

See all (224)

Therapy

Germline genetic variability in pancreatic cancer risk and prognosis.

Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625

Complete and Durable Response to Nivolumab in Recurrent Poorly Differentiated Pancreatic Neuroendocrine Carcinoma with High Tumor Mutational Burden.

Kang NW, Tan KT, Li CF, Kuo YH
Curr Oncol 2021 Nov 10;28(6):4587-4596. doi: 10.3390/curroncol28060388. PMID: 34898561 Free PMC Article

Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.

Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025 Free PMC Article

Are There Indications for Total Pancreatectomy in 2016?

Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746

See all (74)

Prognosis

Germline genetic variability in pancreatic cancer risk and prognosis.

Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625

Molecular radionuclide imaging of pancreatic neoplasms.

Panda A, Garg I, Johnson GB, Truty MJ, Halfdanarson TR, Goenka AH
Lancet Gastroenterol Hepatol 2019 Jul;4(7):559-570. doi: 10.1016/S2468-1253(19)30081-0. PMID: 31169124

Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.

Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025 Free PMC Article

Imaging of neuroendocrine tumors of the pancreas.

Dromain C, Déandréis D, Scoazec JY, Goere D, Ducreux M, Baudin E, Tselikas L
Diagn Interv Imaging 2016 Dec;97(12):1241-1257. Epub 2016 Nov 18 doi: 10.1016/j.diii.2016.07.012. PMID: 27876341

Gastrinoma--morphological aspects.

Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

See all (179)

Clinical prediction guides

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.

Germline genetic variability in pancreatic cancer risk and prognosis.

Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625

Neuroendocrine carcinoma and mixed neuroendocrine‒non-neuroendocrine neoplasm of the stomach: a clinicopathological and exome sequencing study.

Ishida S, Akita M, Fujikura K, Komatsu M, Sawada R, Matsumoto H, Saegusa J, Itoh T, Kakeji Y, Zen Y
Hum Pathol 2021 Apr;110:1-10. Epub 2021 Jan 21 doi: 10.1016/j.humpath.2020.12.008. PMID: 33359239

Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion.

LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623

Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges.

Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609

See all (99)

Recent systematic reviews

Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature.

Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791 Free PMC Article

Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis.

Andreasi V, Ricci C, Partelli S, Guarneri G, Ingaldi C, Muffatti F, Crippa S, Casadei R, Falconi M
J Endocrinol Invest 2022 Apr;45(4):705-718. Epub 2021 Nov 13 doi: 10.1007/s40618-021-01705-2. PMID: 34773595

Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.

Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985

External Beam Radiotherapy in the Treatment of Gastroenteropancreatic Neuroendocrine Tumours: A Systematic Review.

Chan DL, Thompson R, Lam M, Pavlakis N, Hallet J, Law C, Singh S, Myrehaug S
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):400-408. Epub 2018 Mar 31 doi: 10.1016/j.clon.2018.03.006. PMID: 29615284

Liver transplantation for hepatic metastases of neuroendocrine pancreatic tumors: a survival-based analysis.

Máthé Z, Tagkalos E, Paul A, Molmenti EP, Kóbori L, Fouzas I, Beckebaum S, Sotiropoulos GC
Transplantation 2011 Mar 15;91(5):575-82. doi: 10.1097/TP.0b013e3182081312. PMID: 21200365

See all (6)

MedGen

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Recurrent Pancreatic Neuroendocrine Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity