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Intraparenchymal Hemorrhage of the Newborn

MedGen UID:
858296
•Concept ID:
C3898702
•
Finding
Synonym: Parenchymal Hemorrhage of the Newborn

Definition

Bleeding into the brain tissue of a newborn infant. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntraparenchymal Hemorrhage of the Newborn

Professional guidelines

PubMed

Use of the expanded Apgar score for the assessment of intraventricular and intraparenchymal haemorrhage risk in neonates.
Goralska A, Puskarz-Gasowska JE, Bujnowski P, Bokiniec R
Ginekol Pol 2023;94(2):146-151. Epub 2022 Jul 27 doi: 10.5603/GP.a2022.0046. PMID: 35894485
Outcome Trajectories after Primary Perinatal Hemorrhagic Stroke.
Porcari GS, Jordan LC, Ichord RN, Licht DJ, Smith SE, Beslow LA
Pediatr Neurol 2020 Apr;105:41-47. Epub 2019 Dec 9 doi: 10.1016/j.pediatrneurol.2019.11.019. PMID: 31952959Free PMC Article
Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage.
Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, Uysal G, Tas M, Musa K
Childs Nerv Syst 2014 Mar;30(3):411-8. Epub 2013 Aug 2 doi: 10.1007/s00381-013-2243-0. PMID: 23907139

Recent clinical studies

Etiology

Spectrum of Fetal Intraparenchymal Hemorrhage in COL4A1/A2-Related Disorders.
George E, Vassar R, Mogga A, Li Y, Norton ME, Gano D, Glenn OA
Pediatr Neurol 2023 Oct;147:63-67. Epub 2023 Jul 18 doi: 10.1016/j.pediatrneurol.2023.07.008. PMID: 37562171
Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5.
Tréluyer L, Chevallier M, Jarreau PH, Baud O, Benhammou V, Gire C, Marchand-Martin L, Marret S, Pierrat V, Ancel PY, Torchin H
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059138. PMID: 36919442Free PMC Article
Intracranial Hemorrhage in Term and Late-Preterm Neonates: An Institutional Perspective.
Sandoval Karamian AG, Yang QZ, Tam LT, Rao VL, Tong E, Yeom KW
AJNR Am J Neuroradiol 2022 Oct;43(10):1494-1499. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7642. PMID: 36137666Free PMC Article
Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage.
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ
Neurocrit Care 2021 Aug;35(1):255-261. Epub 2021 Jan 6 doi: 10.1007/s12028-020-01161-5. PMID: 33403588Free PMC Article
aEEG in preterm infants.
Scoppa A, Casani A, Cocca F, Coletta C, De Luca MG, Di Manso G, Grappone L, Pozzi N, Orfeo L
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:139-40. doi: 10.3109/14767058.2012.714971. PMID: 22958046

Diagnosis

Characterization of germinal matrix hemorrhage in extremely premature infants: recognition of posterior location and diagnostic pitfalls.
Snyder EJ, Pruthi S, Hernanz-Schulman M
Pediatr Radiol 2022 Jan;52(1):75-84. Epub 2021 Sep 15 doi: 10.1007/s00247-021-05189-3. PMID: 34528114
Feasibility and Safety of Contrast-Enhanced Ultrasound of the Neonatal Brain: A Prospective Study Using MRI as the Reference Standard.
Squires JH, Beluk NH, Lee VK, Yanowitz TD, Gumus S, Subramanian S, Panigrahy A
AJR Am J Roentgenol 2022 Jan;218(1):152-161. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26274. PMID: 34286594
Prenatal diagnosis and postnatal outcome of fetal intracranial hemorrhage.
Kutuk MS, Yikilmaz A, Ozgun MT, Dolanbay M, Canpolat M, Uludag S, Uysal G, Tas M, Musa K
Childs Nerv Syst 2014 Mar;30(3):411-8. Epub 2013 Aug 2 doi: 10.1007/s00381-013-2243-0. PMID: 23907139
aEEG in preterm infants.
Scoppa A, Casani A, Cocca F, Coletta C, De Luca MG, Di Manso G, Grappone L, Pozzi N, Orfeo L
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:139-40. doi: 10.3109/14767058.2012.714971. PMID: 22958046
The natural history of subependymal germinal matrix hemorrhage.
Enzmann D, Murphy-Irwin K, Stevenson D, Ariagno R, Barton J, Sunshine P
Am J Perinatol 1985 Apr;2(2):123-33. doi: 10.1055/s-2007-999929. PMID: 3913430

Therapy

Feasibility and Safety of Contrast-Enhanced Ultrasound of the Neonatal Brain: A Prospective Study Using MRI as the Reference Standard.
Squires JH, Beluk NH, Lee VK, Yanowitz TD, Gumus S, Subramanian S, Panigrahy A
AJR Am J Roentgenol 2022 Jan;218(1):152-161. Epub 2021 Jul 21 doi: 10.2214/AJR.21.26274. PMID: 34286594
Minimally invasive therapy for the resolution of a subcapsular hepatic hematoma in a newborn.
Santos C M, Zamboni T GP, Hasson D, Poblete S M, Vargas H P
Andes Pediatr 2021 Feb;92(1):99-103. Epub 2021 Feb 22 doi: 10.32641/andespediatr.v92i1.2375. PMID: 34106189
Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage.
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ
Neurocrit Care 2021 Aug;35(1):255-261. Epub 2021 Jan 6 doi: 10.1007/s12028-020-01161-5. PMID: 33403588Free PMC Article
Unusual complication of fulminant congenital cytomegalovirus infection.
Arun Babu T, Soliman Y, Mohammad K
J Neonatal Perinatal Med 2018;11(2):203-208. doi: 10.3233/NPM-181687. PMID: 29843259
Neonatal cocaine-related seizures.
Kramer LD, Locke GE, Ogunyemi A, Nelson L
J Child Neurol 1990 Jan;5(1):60-4. doi: 10.1177/088307389000500115. PMID: 2299141

Prognosis

Intraventricular Hemorrhage in Very Preterm Children: Mortality and Neurodevelopment at Age 5.
Tréluyer L, Chevallier M, Jarreau PH, Baud O, Benhammou V, Gire C, Marchand-Martin L, Marret S, Pierrat V, Ancel PY, Torchin H
Pediatrics 2023 Apr 1;151(4) doi: 10.1542/peds.2022-059138. PMID: 36919442Free PMC Article
Use of the expanded Apgar score for the assessment of intraventricular and intraparenchymal haemorrhage risk in neonates.
Goralska A, Puskarz-Gasowska JE, Bujnowski P, Bokiniec R
Ginekol Pol 2023;94(2):146-151. Epub 2022 Jul 27 doi: 10.5603/GP.a2022.0046. PMID: 35894485
Predicting mortality in traumatic intracranial hemorrhage.
Powers AY, Pinto MB, Tang OY, Chen JS, Doberstein C, Asaad WF
J Neurosurg 2019 Feb 22;132(2):552-559. doi: 10.3171/2018.11.JNS182199. PMID: 30797192
Intracranial hemorrhage in term neonates.
Hong HS, Lee JY
Childs Nerv Syst 2018 Jun;34(6):1135-1143. Epub 2018 Apr 10 doi: 10.1007/s00381-018-3788-8. PMID: 29637304Free PMC Article
aEEG in preterm infants.
Scoppa A, Casani A, Cocca F, Coletta C, De Luca MG, Di Manso G, Grappone L, Pozzi N, Orfeo L
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:139-40. doi: 10.3109/14767058.2012.714971. PMID: 22958046

Clinical prediction guides

Clinical presentation, natural history, and outcomes for infantile intracranial cavernous malformations: case series and systematic review of the literature.
Goyal A, Fernandes-Torres J, Flemming KD, Williams LN, Daniels DJ
Childs Nerv Syst 2023 Jun;39(6):1545-1554. Epub 2023 Mar 14 doi: 10.1007/s00381-023-05903-6. PMID: 36917267
Use of the expanded Apgar score for the assessment of intraventricular and intraparenchymal haemorrhage risk in neonates.
Goralska A, Puskarz-Gasowska JE, Bujnowski P, Bokiniec R
Ginekol Pol 2023;94(2):146-151. Epub 2022 Jul 27 doi: 10.5603/GP.a2022.0046. PMID: 35894485
Characterization of germinal matrix hemorrhage in extremely premature infants: recognition of posterior location and diagnostic pitfalls.
Snyder EJ, Pruthi S, Hernanz-Schulman M
Pediatr Radiol 2022 Jan;52(1):75-84. Epub 2021 Sep 15 doi: 10.1007/s00247-021-05189-3. PMID: 34528114
Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage.
Ammar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ
Neurocrit Care 2021 Aug;35(1):255-261. Epub 2021 Jan 6 doi: 10.1007/s12028-020-01161-5. PMID: 33403588Free PMC Article
aEEG in preterm infants.
Scoppa A, Casani A, Cocca F, Coletta C, De Luca MG, Di Manso G, Grappone L, Pozzi N, Orfeo L
J Matern Fetal Neonatal Med 2012 Oct;25 Suppl 4:139-40. doi: 10.3109/14767058.2012.714971. PMID: 22958046

Recent systematic reviews

Clinical presentation, natural history, and outcomes for infantile intracranial cavernous malformations: case series and systematic review of the literature.
Goyal A, Fernandes-Torres J, Flemming KD, Williams LN, Daniels DJ
Childs Nerv Syst 2023 Jun;39(6):1545-1554. Epub 2023 Mar 14 doi: 10.1007/s00381-023-05903-6. PMID: 36917267
Blunt prenatal trauma resulting in fetal epidural or subdural hematoma: case report and systematic review of the literature.
Joseph JR, Smith BW, Garton HJ
J Neurosurg Pediatr 2017 Jan;19(1):32-37. Epub 2016 Oct 14 doi: 10.3171/2016.7.PEDS16282. PMID: 27739945

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