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Trophic changes related to pain

MedGen UID:
866865
•Concept ID:
C4021220
•
Finding
Synonym: Trophic changes
 
HPO: HP:0010834

Definition

Trophic changes is a term used to describe abnormalities in the area of pain that include primarily wasting away of the skin, tissues, or muscle, thinning of the bones, and changes in how the hair or nails grow, including thickening or thinning of hair or brittle nails. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTrophic changes related to pain

Professional guidelines

PubMed

Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review.
Javed S, Abdi S
Pain Manag 2021 Mar;11(2):189-199. Epub 2020 Nov 13 doi: 10.2217/pmt-2020-0060. PMID: 33183126
Spinal cord stimulation for the treatment of complex regional pain syndrome leads to improvement of quality of life, reduction of pain and psychological distress: a retrospective case series with 24 months follow up.
Schwarm FP, Stein M, Uhl E, Maxeiner H, Kolodziej MA
Scand J Pain 2020 Apr 28;20(2):253-259. doi: 10.1515/sjpain-2019-0081. PMID: 31743107
Bisphosphonates in the treatment of complex regional pain syndrome: is bone the main player at early stage of the disease?
Varenna M, Crotti C
Rheumatol Int 2018 Nov;38(11):1959-1962. Epub 2018 Jul 14 doi: 10.1007/s00296-018-4101-6. PMID: 30008128

Recent clinical studies

Etiology

Post-stroke complex regional pain syndrome and related factors: Experiences from a tertiary rehabilitation center.
Altas EU, Onat ŞŞ, Konak HE, Polat CS
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104995. Epub 2020 Jul 3 doi: 10.1016/j.jstrokecerebrovasdis.2020.104995. PMID: 32807418
Changes resembling complex regional pain syndrome following surgery and immobilization.
Pepper A, Li W, Kingery WS, Angst MS, Curtin CM, Clark JD
J Pain 2013 May;14(5):516-24. Epub 2013 Feb 28 doi: 10.1016/j.jpain.2013.01.004. PMID: 23453564Free PMC Article
Critical limb ischemia.
Gresele P, Busti C, Fierro T
Intern Emerg Med 2011 Oct;6 Suppl 1:129-34. doi: 10.1007/s11739-011-0683-7. PMID: 22009625
Clinical expression profiles of complex regional pain syndrome, fibromyalgia and a-specific repetitive strain injury: more common denominators than pain?
Marinus J, Van Hilten JJ
Disabil Rehabil 2006 Mar 30;28(6):351-62. doi: 10.1080/09638280500287320. PMID: 16492631
Maintaining and restoring mobility in middle and old age: the importance of the soft tissues.
Buckwalter JA
Instr Course Lect 1997;46:459-69. PMID: 9143988

Diagnosis

Cephalgia Alopecia.
Bedrin KO, Dougherty C
Curr Pain Headache Rep 2020 Jul 15;24(9):46. doi: 10.1007/s11916-020-00880-w. PMID: 32671496
Complex regional pain syndrome: An optimistic perspective.
Birklein F, O'Neill D, Schlereth T
Neurology 2015 Jan 6;84(1):89-96. Epub 2014 Dec 3 doi: 10.1212/WNL.0000000000001095. PMID: 25471395
Critical limb ischemia.
Gresele P, Busti C, Fierro T
Intern Emerg Med 2011 Oct;6 Suppl 1:129-34. doi: 10.1007/s11739-011-0683-7. PMID: 22009625
The role of peripheral nerve surgery in diabetic limb salvage.
Ducic I, Felder JM 3rd, Iorio ML
Plast Reconstr Surg 2011 Jan;127 Suppl 1:259S-269S. doi: 10.1097/PRS.0b013e31820063d4. PMID: 21200300
Autonomic dysfunction in rheumatic diseases.
Straub RH, Baerwald CG, Wahle M, Jänig W
Rheum Dis Clin North Am 2005 Feb;31(1):61-75, viii. doi: 10.1016/j.rdc.2004.09.002. PMID: 15639056

Therapy

Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review.
Javed S, Abdi S
Pain Manag 2021 Mar;11(2):189-199. Epub 2020 Nov 13 doi: 10.2217/pmt-2020-0060. PMID: 33183126
Cephalgia Alopecia.
Bedrin KO, Dougherty C
Curr Pain Headache Rep 2020 Jul 15;24(9):46. doi: 10.1007/s11916-020-00880-w. PMID: 32671496
What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature.
Grieve S, Jones L, Walsh N, McCabe C
Eur J Pain 2016 Mar;20(3):331-40. Epub 2015 Jun 15 doi: 10.1002/ejp.733. PMID: 26075938
Complex regional pain syndrome: An optimistic perspective.
Birklein F, O'Neill D, Schlereth T
Neurology 2015 Jan 6;84(1):89-96. Epub 2014 Dec 3 doi: 10.1212/WNL.0000000000001095. PMID: 25471395
Brain-derived neurotrophic factor as a drug target for CNS disorders.
Pezet S, Malcangio M
Expert Opin Ther Targets 2004 Oct;8(5):391-9. doi: 10.1517/14728222.8.5.391. PMID: 15469390

Prognosis

Post-stroke complex regional pain syndrome and related factors: Experiences from a tertiary rehabilitation center.
Altas EU, Onat ŞŞ, Konak HE, Polat CS
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104995. Epub 2020 Jul 3 doi: 10.1016/j.jstrokecerebrovasdis.2020.104995. PMID: 32807418
Bisphosphonates in the treatment of complex regional pain syndrome: is bone the main player at early stage of the disease?
Varenna M, Crotti C
Rheumatol Int 2018 Nov;38(11):1959-1962. Epub 2018 Jul 14 doi: 10.1007/s00296-018-4101-6. PMID: 30008128
Neuropathic Pain and Nerve Growth Factor in Chemotherapy-Induced Peripheral Neuropathy: Prospective Clinical-Pathological Study.
Velasco R, Navarro X, Gil-Gil M, Herrando-Grabulosa M, Calls A, Bruna J
J Pain Symptom Manage 2017 Dec;54(6):815-825. Epub 2017 Aug 8 doi: 10.1016/j.jpainsymman.2017.04.021. PMID: 28797868
Complex regional pain syndrome: An optimistic perspective.
Birklein F, O'Neill D, Schlereth T
Neurology 2015 Jan 6;84(1):89-96. Epub 2014 Dec 3 doi: 10.1212/WNL.0000000000001095. PMID: 25471395
Clinical expression profiles of complex regional pain syndrome, fibromyalgia and a-specific repetitive strain injury: more common denominators than pain?
Marinus J, Van Hilten JJ
Disabil Rehabil 2006 Mar 30;28(6):351-62. doi: 10.1080/09638280500287320. PMID: 16492631

Clinical prediction guides

Post-stroke complex regional pain syndrome and related factors: Experiences from a tertiary rehabilitation center.
Altas EU, Onat ŞŞ, Konak HE, Polat CS
J Stroke Cerebrovasc Dis 2020 Sep;29(9):104995. Epub 2020 Jul 3 doi: 10.1016/j.jstrokecerebrovasdis.2020.104995. PMID: 32807418
Spinal cord stimulation for the treatment of complex regional pain syndrome leads to improvement of quality of life, reduction of pain and psychological distress: a retrospective case series with 24 months follow up.
Schwarm FP, Stein M, Uhl E, Maxeiner H, Kolodziej MA
Scand J Pain 2020 Apr 28;20(2):253-259. doi: 10.1515/sjpain-2019-0081. PMID: 31743107
Neuropathic Pain and Nerve Growth Factor in Chemotherapy-Induced Peripheral Neuropathy: Prospective Clinical-Pathological Study.
Velasco R, Navarro X, Gil-Gil M, Herrando-Grabulosa M, Calls A, Bruna J
J Pain Symptom Manage 2017 Dec;54(6):815-825. Epub 2017 Aug 8 doi: 10.1016/j.jpainsymman.2017.04.021. PMID: 28797868
Changes resembling complex regional pain syndrome following surgery and immobilization.
Pepper A, Li W, Kingery WS, Angst MS, Curtin CM, Clark JD
J Pain 2013 May;14(5):516-24. Epub 2013 Feb 28 doi: 10.1016/j.jpain.2013.01.004. PMID: 23453564Free PMC Article
Complex interaction of sensory and motor signs and symptoms in chronic CRPS.
Huge V, Lauchart M, Magerl W, Beyer A, Moehnle P, Kaufhold W, Schelling G, Azad SC
PLoS One 2011 Apr 29;6(4):e18775. doi: 10.1371/journal.pone.0018775. PMID: 21559525Free PMC Article

Recent systematic reviews

What outcome measures are commonly used for Complex Regional Pain Syndrome clinical trials? A systematic review of the literature.
Grieve S, Jones L, Walsh N, McCabe C
Eur J Pain 2016 Mar;20(3):331-40. Epub 2015 Jun 15 doi: 10.1002/ejp.733. PMID: 26075938

Supplemental Content

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