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Decreased number of sweat glands

MedGen UID:
867216
•Concept ID:
C4021574
•
Finding
Synonyms: Decreased sweat glands; Decreased sweat pores
 
HPO: HP:0007500

Definition

The presence of fewer than normal sweat glands. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased number of sweat glands

Conditions with this feature

Rapp-Hodgkin ectodermal dysplasia syndrome
MedGen UID:
315656
•Concept ID:
C1785148
•
Disease or Syndrome
The TP63-related disorders comprise six overlapping phenotypes: Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome (which includes Rapp-Hodgkin syndrome). Acro-dermo-ungual-lacrimal-tooth (ADULT) syndrome. Ectrodactyly, ectodermal dysplasia, cleft lip/palate syndrome 3 (EEC3). Limb-mammary syndrome. Split-hand/foot malformation type 4 (SHFM4). Isolated cleft lip/cleft palate (orofacial cleft 8). Individuals typically have varying combinations of ectodermal dysplasia (hypohidrosis, nail dysplasia, sparse hair, tooth abnormalities), cleft lip/palate, split-hand/foot malformation/syndactyly, lacrimal duct obstruction, hypopigmentation, hypoplastic breasts and/or nipples, and hypospadias. Findings associated with a single phenotype include ankyloblepharon filiforme adnatum (tissue strands that completely or partially fuse the upper and lower eyelids), skin erosions especially on the scalp associated with areas of scarring, and alopecia, trismus, and excessive freckling.
See: Condition Record
Hypohidrosis with abnormal palmar dermal Ridges
MedGen UID:
340989
•Concept ID:
C1855856
•
Disease or Syndrome
See: Condition Record
Hypohidrosis with abnormal palmar dermal Ridges
Rapp-Hodgkin ectodermal dysplasia syndrome

Professional guidelines

PubMed

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis.
Zhang Y, Gong YY, Tang YL, Bai YS, Yang K, Chen HY, Zhang QA, Wang JA, Zhu YF, Li HY, Liu QM, Lin JR, Wu WY
Dermatol Ther 2022 Aug;35(8):e15657. Epub 2022 Jun 29 doi: 10.1111/dth.15657. PMID: 35726636
Efficacy of fractional microneedle radiofrequency device in the treatment of primary axillary hyperhidrosis: a pilot study.
Kim M, Shin JY, Lee J, Kim JY, Oh SH
Dermatology 2013;227(3):243-9. Epub 2013 Oct 4 doi: 10.1159/000354602. PMID: 24107595

Recent clinical studies

Etiology

Obesity is Not Associated With Need for Skin Grafting After Hidradenitis Excision.
Colosimo C, Yon JR, Fredericks C, Kingsley S, Gupta S, Mentzer CJ, Bokhari F, Poulakidas S
Am Surg 2021 Mar;87(3):458-462. Epub 2020 Oct 13 doi: 10.1177/0003134820950686. PMID: 33047967
Run performance of middle-aged and young adult runners in the heat.
de Paula Viveiros J, Amorim FT, Alves MN, Passos RL, Meyer F
Int J Sports Med 2012 Mar;33(3):211-7. Epub 2011 Dec 8 doi: 10.1055/s-0031-1295444. PMID: 22161295
Changes in the number of active sweat glands (palmar sweat index, PSI) during a distressing film.
Köhler T, Schuschel I
Biol Psychol 1994 Mar;37(2):133-45. doi: 10.1016/0301-0511(94)90027-2. PMID: 8003589
Effect of age on heat-activated sweat gland density and flow during exercise in dry heat.
Anderson RK, Kenney WL
J Appl Physiol (1985) 1987 Sep;63(3):1089-94. doi: 10.1152/jappl.1987.63.3.1089. PMID: 3654456
Structural and functional changes of normal aging skin.
Fenske NA, Lober CW
J Am Acad Dermatol 1986 Oct;15(4 Pt 1):571-85. doi: 10.1016/s0190-9622(86)70208-9. PMID: 3534008

Diagnosis

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis.
Zhang Y, Gong YY, Tang YL, Bai YS, Yang K, Chen HY, Zhang QA, Wang JA, Zhu YF, Li HY, Liu QM, Lin JR, Wu WY
Dermatol Ther 2022 Aug;35(8):e15657. Epub 2022 Jun 29 doi: 10.1111/dth.15657. PMID: 35726636
A device to measure secretion of individual sweat glands for diagnosis of peripheral neuropathy.
Loavenbruck AJ, Hodges JS, Provitera V, Nolano M, Wendelshafer-Crabb G, Kennedy WR
J Peripher Nerv Syst 2017 Jun;22(2):139-148. doi: 10.1111/jns.12212. PMID: 28429515
Hyperhidrosis in Parkinson's disease.
Schestatsky P, Valls-Solé J, Ehlers JA, Rieder CR, Gomes I
Mov Disord 2006 Oct;21(10):1744-8. doi: 10.1002/mds.21006. PMID: 16773622
Pharmacophysiology of atopic dermatitis.
Hanifin JM
Clin Rev Allergy 1986 Feb;4(1):43-65. doi: 10.1007/BF02991187. PMID: 3008974
Morphea of the eyelids.
El-Baba F, Frangieh GT, Iliff WJ, Hood AB, Green WR
Ophthalmology 1982 Nov;89(11):1285-8. doi: 10.1016/s0161-6420(82)34643-6. PMID: 7155536

Therapy

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis.
Zhang Y, Gong YY, Tang YL, Bai YS, Yang K, Chen HY, Zhang QA, Wang JA, Zhu YF, Li HY, Liu QM, Lin JR, Wu WY
Dermatol Ther 2022 Aug;35(8):e15657. Epub 2022 Jun 29 doi: 10.1111/dth.15657. PMID: 35726636
Image-based β-adrenergic sweat rate assay captures minimal cystic fibrosis transmembrane conductance regulator function.
Salinas DB, Peng YH, Horwich B, Wee CP, Frisbee E, Maarek JM
Pediatr Res 2020 Jan;87(1):137-145. Epub 2019 Jul 25 doi: 10.1038/s41390-019-0503-8. PMID: 31344706Free PMC Article
Lichen amyloidosus as a sweat gland/duct-related disorder: resolution associated with restoration of sweating disturbance.
Shimoda Y, Sato Y, Hayashida Y, Yamazaki Y, Mizukawa Y, Nakajima K, Shiohara T, Aoyama Y
Br J Dermatol 2017 May;176(5):1308-1315. Epub 2017 Apr 7 doi: 10.1111/bjd.15060. PMID: 27628905
Verneuil's disease, innate immunity and vitamin D: a pilot study.
Guillet A, Brocard A, Bach Ngohou K, Graveline N, Leloup AG, Ali D, Nguyen JM, Loirat MJ, Chevalier C, Khammari A, Dreno B
J Eur Acad Dermatol Venereol 2015 Jul;29(7):1347-53. Epub 2014 Dec 16 doi: 10.1111/jdv.12857. PMID: 25512084
Comparison of the effects of high ambient temperature and clonidine on autonomic functions in man.
Arya DK, Langley RW, Szabadi E, Bradshaw CM
Naunyn Schmiedebergs Arch Pharmacol 1997 Mar;355(3):376-83. doi: 10.1007/pl00004957. PMID: 9089669

Prognosis

Image-based β-adrenergic sweat rate assay captures minimal cystic fibrosis transmembrane conductance regulator function.
Salinas DB, Peng YH, Horwich B, Wee CP, Frisbee E, Maarek JM
Pediatr Res 2020 Jan;87(1):137-145. Epub 2019 Jul 25 doi: 10.1038/s41390-019-0503-8. PMID: 31344706Free PMC Article
Skin pretreatment with microneedles prior to pilocarpine iontophoresis increases sweat production.
Wing D, Prausnitz MR, Buono MJ
Clin Physiol Funct Imaging 2013 Nov;33(6):436-40. Epub 2013 May 13 doi: 10.1111/cpf.12053. PMID: 23701521
Localized β-adrenergic receptor blockade does not affect sweating during exercise.
Buono MJ, Tabor B, White A
Am J Physiol Regul Integr Comp Physiol 2011 May;300(5):R1148-51. Epub 2011 Feb 16 doi: 10.1152/ajpregu.00228.2010. PMID: 21325648
Matrix metalloproteinase-2 (72 kD type IV collagenase) expression occurs in the early stage of human melanocytic tumour progression and may have prognostic value.
Väisänen A, Tuominen H, Kallioinen M, Turpeenniemi-Hujanen T
J Pathol 1996 Nov;180(3):283-9. doi: 10.1002/(SICI)1096-9896(199611)180:3<283::AID-PATH662>3.0.CO;2-3. PMID: 8958806
Anhidrosis (hypohidrosis) in Sjögren's syndrome.
Mitchell J, Greenspan J, Daniels T, Whitcher JP, Maibach HI
J Am Acad Dermatol 1987 Jan;16(1 Pt 2):233-5. doi: 10.1016/s0190-9622(87)80070-1. PMID: 3819059

Clinical prediction guides

Clinical efficacy of microwave in the treatment of axillary osmidrosis and primary hyperhidrosis.
Zhang Y, Gong YY, Tang YL, Bai YS, Yang K, Chen HY, Zhang QA, Wang JA, Zhu YF, Li HY, Liu QM, Lin JR, Wu WY
Dermatol Ther 2022 Aug;35(8):e15657. Epub 2022 Jun 29 doi: 10.1111/dth.15657. PMID: 35726636
Image-based β-adrenergic sweat rate assay captures minimal cystic fibrosis transmembrane conductance regulator function.
Salinas DB, Peng YH, Horwich B, Wee CP, Frisbee E, Maarek JM
Pediatr Res 2020 Jan;87(1):137-145. Epub 2019 Jul 25 doi: 10.1038/s41390-019-0503-8. PMID: 31344706Free PMC Article
Verneuil's disease, innate immunity and vitamin D: a pilot study.
Guillet A, Brocard A, Bach Ngohou K, Graveline N, Leloup AG, Ali D, Nguyen JM, Loirat MJ, Chevalier C, Khammari A, Dreno B
J Eur Acad Dermatol Venereol 2015 Jul;29(7):1347-53. Epub 2014 Dec 16 doi: 10.1111/jdv.12857. PMID: 25512084
Run performance of middle-aged and young adult runners in the heat.
de Paula Viveiros J, Amorim FT, Alves MN, Passos RL, Meyer F
Int J Sports Med 2012 Mar;33(3):211-7. Epub 2011 Dec 8 doi: 10.1055/s-0031-1295444. PMID: 22161295
Changes in the number of active sweat glands (palmar sweat index, PSI) during a distressing film.
Köhler T, Schuschel I
Biol Psychol 1994 Mar;37(2):133-45. doi: 10.1016/0301-0511(94)90027-2. PMID: 8003589

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