Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Abnormal epiphysis morphology

MedGen UID:: 867251
•Concept ID:: C4021611
•: Anatomical Abnormality

Synonyms:	Abnormal shape of end part of bone; Abnormality of epiphysis morphology; Abnormality of the epiphyses; Anomaly of the epiphyses; Epiphyseal abnormality

HPO:	HP:0005930

Definition

An anomaly of epiphysis, which is the expanded articular end of a long bone that developes from a secondary ossification center, and which during the period of growth is either entirely cartilaginous or is separated from the shaft by a cartilaginous disk. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormal epiphysis morphology

Phenotypic abnormality
- Abnormality of the musculoskeletal system
  - Abnormality of the skeletal system
    - Abnormal skeletal morphology
      - Abnormal appendicular skeleton morphology
        Abnormal long bone morphology
        Abnormal epiphysis morphology
        Abnormal limb epiphysis morphology
        Abnormal lower limb epiphysis morphology
        Abnormal femoral epiphysis morphology
        Abnormal fibular epiphysis morphology
        Abnormality of the epiphyses of the feet
        Abnormality of tibial epiphyses
        Abnormal upper limb epiphysis morphology
        Abnormality of radial epiphyses
        Abnormality of the humeral epiphysis
        Delayed upper limb epiphyseal ossification
        Round epiphyses of the upper limbs
        Wide epiphyseal plates of the upper limbs
        Abnormal vertebral epiphysis morphology
        Absent epiphyses
        Absent epiphyses of the phalanges of the hand
        Absent epiphyses of the 2nd finger
        Absent epiphyses of the 3rd finger
        Absent epiphyses of the 4th finger
        Absent epiphyses of the 5th finger
        Absent epiphyses of the thumb
        Absent epiphyses of the toes
        Absent hallux epiphysis
        Absent metacarpal epiphyses
        Aplasia/Hypoplasia of the capital femoral epiphysis
        Hypoplasia of the capital femoral epiphysis
        Bracket epiphyses
        Bracket epiphyses of the phalanges of the hand
        Bracket epiphyses of the 2nd finger
        Bracket epiphyses of the 3rd finger
        Bracket epiphyses of the 4th finger
        Bracket epiphyses of the 5th finger
        Bracket epiphyses of the thumb
        Bracket epiphyses of the toes
        Bracket epiphyses of the hallux
        Cone-shaped epiphysis
        Cone-shaped capital femoral epiphysis
        Cone-shaped distal radial epiphysis
        Cone-shaped epiphyses fused within their metaphyses
        Cone-shaped metacarpal epiphyses
        Phalangeal cone-shaped epiphyses
        Cone-shaped epiphyses of the phalanges of the hand
        Cone-shaped epiphyses of the toes
        Enlarged epiphyses
        Bulging epiphyses
        Enlarged epiphyses of the phalanges of the hand
        Enlarged epiphyses of the 2nd finger
        Enlarged epiphyses of the 3rd finger
        Enlarged epiphyses of the 4th finger
        Enlarged epiphyses of the 5th finger
        Enlarged thumb epiphysis
        Enlarged epiphyses of the toes
        Enlarged epiphyses of the hallux
        Enlarged metacarpal epiphyses
        Enlargement of the proximal femoral epiphysis
        Large humeral epiphyses
        Large radial epiphyses
        Wide epiphyses of the upper limbs
        Broad humeral epiphyses
        Epiphyseal deformities of tubular bones
        Epiphyseal dysplasia
        Epiphyseal streaking
        Flattened epiphysis
        Flattened femoral epiphysis
        Flat capital femoral epiphysis
        Flat distal femoral epiphysis
        Flattened, squared-off epiphyses of tubular bones
        Fragmented epiphyses
        Fractured epiphysis
        Fractured distal epiphysis of distal phalanx of manual digit 1
        Fractured distal epiphysis of radius
        Fractured epiphysis of femur
        Fractured epiphysis of fifth metacarpal bone
        Fractured epiphysis of first metatarsal bone
        Fractured epiphysis of fourth metacarpal bone
        Fractured epiphysis of middle phalanx of manus
        Fractured epiphysis of second metacarpal bone
        Fractured epiphysis of second metatarsal bone
        Fractured epiphysis of third metacarpal bone
        Fractured epiphysis of third metatarsal bone
        Fractured proximal epiphysis of first metacarpal bone
        Fragmentation of the epiphyses of the toes
        Fragmentation of the epiphyses of the hallux
        Fragmented epiphyses of the upper limbs
        Fragmented, irregular epiphyses
        Irregular epiphyses
        Irregular epiphyses of the toes
        Irregular epiphyses of the hallux
        Irregular epiphyses of the upper limbs
        Irregular femoral epiphysis
        Irregular radial epiphyses
        Ivory epiphyses
        Ivory epiphyses of the toes
        Ivory epiphyses of the hallux
        Premature epimetaphyseal fusion
        Premature epimetaphyseal fusion in fibula
        Premature epimetaphyseal fusion in foot
        Premature epimetaphyseal fusion in hand
        Premature epimetaphyseal fusion in radius
        Premature epimetaphyseal fusion in tibia
        Premature epimetaphyseal fusion in ulna
        Pseudoepiphyses
        Pseudoepiphyses of hand bones
        Pseudoepiphyses of the toes
        Pseudoepiphyses of the hallux
        Small epiphyses
        Small epiphyses of the metacarpals
        Small epiphyses of the phalanges of the hand
        Small epiphyses of the 2nd finger
        Small epiphyses of the 3rd finger
        Small epiphyses of the 4th finger
        Small epiphyses of the 5th finger
        Small thumb epiphysis
        Small epiphyses of the toes
        Small epiphyses of the hallux
        Small epiphyses of the upper limbs
        Small radial epiphyses
        Splayed epiphyses
        Triangular epiphysis
        Triangular epiphyses of the metacarpals
        Triangular epiphyses of the phalanges of the hand
        Triangular epiphyses of the 2nd finger
        Triangular epiphyses of the 3rd finger
        Triangular epiphyses of the 4th finger
        Triangular epiphyses of the 5th finger
        Triangular epiphyses of the thumb
        Triangular epiphyses of the toes
        Triangular epiphyses of the hallux

Professional guidelines

PubMed

Hip pain in the young adult: diagnosis and treatment of disorders of the acetabular labrum and acetabular dysplasia.

Hickman JM, Peters CL
Am J Orthop (Belle Mead NJ) 2001 Jun;30(6):459-67. PMID: 11411872

Surgical management of the hip in juvenile chronic arthritis.

McCullough CJ
Br J Rheumatol 1994 Feb;33(2):178-83. doi: 10.1093/rheumatology/33.2.178. PMID: 8162488

Proximal femoral focal deficiency: evaluation and management.

Bryant DD 3rd, Epps CH Jr
Orthopedics 1991 Jul;14(7):775-84. doi: 10.3928/0147-7447-19910701-08. PMID: 1871029

See all (28)

Recent clinical studies

Etiology

Skeletal ciliopathies: a pattern recognition approach.

Handa A, Voss U, Hammarsjö A, Grigelioniene G, Nishimura G
Jpn J Radiol 2020 Mar;38(3):193-206. Epub 2020 Jan 21 doi: 10.1007/s11604-020-00920-w. PMID: 31965514

Growth impairment in mucopolysaccharidoses.

Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275 Free PMC Article

Wolcott-Rallison syndrome.

Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479 Free PMC Article

Musculoskeletal effects of obesity.

Chan G, Chen CT
Curr Opin Pediatr 2009 Feb;21(1):65-70. doi: 10.1097/MOP.0b013e328320a914. PMID: 19242242

Ulnar dysmelia.

Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

See all (417)

Diagnosis

Trichorhinophalangeal syndrome.

Vargas Lebrón C, Ruiz Montesino MD, Moreira Navarrete V, Aróstegui Gorospe JI
Reumatol Clin (Engl Ed) 2020 Nov-Dec;16(6):499-501. Epub 2018 Dec 3 doi: 10.1016/j.reuma.2018.08.015. PMID: 30522940

Radial Polydactyly. What's New?

Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421

Cone-shaped epiphysis.

Durmus O, Cakar E, Ata E, Dincer U, Kiralp MZ
Am J Phys Med Rehabil 2014 Jan;93(1):92-3. doi: 10.1097/PHM.0b013e3182644034. PMID: 22854906

Wolcott-Rallison syndrome.

Juneja A, Sultan A, Bhatnagar S
J Indian Soc Pedod Prev Dent 2012 Jul-Sep;30(3):250-3. doi: 10.4103/0970-4388.105019. PMID: 23263430

Wolcott-Rallison syndrome.

Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479 Free PMC Article

See all (505)

Therapy

Cellular and Molecular Alterations Underlying Abnormal Bone Growth in X-Linked Hypophosphatemia.

Fuente R, García-Bengoa M, Fernández-Iglesias Á, Gil-Peña H, Santos F, López JM
Int J Mol Sci 2022 Jan 15;23(2) doi: 10.3390/ijms23020934. PMID: 35055123 Free PMC Article

How does the cam morphology develop in athletes? A systematic review and meta-analysis.

Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785

Drug-induced Physeal Abnormalities in Preclinical Toxicity Studies.

Frazier KS
Toxicol Pathol 2017 Oct;45(7):869-875. Epub 2017 Jun 23 doi: 10.1177/0192623317713319. PMID: 28643552

Recent research on the growth plate: Impact of inflammatory cytokines on longitudinal bone growth.

Sederquist B, Fernandez-Vojvodich P, Zaman F, Sävendahl L
J Mol Endocrinol 2014 Aug;53(1):T35-44. Epub 2014 Apr 7 doi: 10.1530/JME-14-0006. PMID: 24711646

Cone-shaped epiphysis.

Durmus O, Cakar E, Ata E, Dincer U, Kiralp MZ
Am J Phys Med Rehabil 2014 Jan;93(1):92-3. doi: 10.1097/PHM.0b013e3182644034. PMID: 22854906

See all (115)

Prognosis

Imaging Review of Normal and Abnormal Skeletal Maturation.

Augusto ACL, Goes PCK, Flores DV, Costa MAF, Takahashi MS, Rodrigues ACO, Padula LC, Gasparetto TD, Nogueira-Barbosa MH, Aihara AY
Radiographics 2022 May-Jun;42(3):861-879. Epub 2022 Feb 25 doi: 10.1148/rg.210088. PMID: 35213260

Growth impairment in mucopolysaccharidoses.

Melbouci M, Mason RW, Suzuki Y, Fukao T, Orii T, Tomatsu S
Mol Genet Metab 2018 May;124(1):1-10. Epub 2018 Mar 16 doi: 10.1016/j.ymgme.2018.03.004. PMID: 29627275 Free PMC Article

Wolcott-Rallison syndrome.

Julier C, Nicolino M
Orphanet J Rare Dis 2010 Nov 4;5:29. doi: 10.1186/1750-1172-5-29. PMID: 21050479 Free PMC Article

Pathogenic mechanisms in osteochondrodysplasias.

Stanescu V, Stanescu R, Maroteaux P
J Bone Joint Surg Am 1984 Jul;66(6):817-36. doi: 10.2106/00004623-198466060-00002. PMID: 6376516

Ulnar dysmelia.

Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

See all (269)

Clinical prediction guides

Imaging Review of Normal and Abnormal Skeletal Maturation.

Radial Polydactyly. What's New?

Perez-Lopez LM, la Iglesia DG, Cabrera-Gonzalez M
Curr Pediatr Rev 2018;14(2):91-96. doi: 10.2174/1573396314666180124102012. PMID: 29366421

Epiphyseal clefts.

Harrison RB, Keats TE
Skeletal Radiol 1980 Feb;5(1):23-7. doi: 10.1007/BF00347094. PMID: 6767277

Coxa magna.

Powers JA, Bach PJ
South Med J 1977 Nov;70(11):1297-9. doi: 10.1097/00007611-197711000-00014. PMID: 918696

Ulnar dysmelia.

Ogden JA, Watson HK, Bohne W
J Bone Joint Surg Am 1976 Jun;58(4):467-75. PMID: 818089

See all (314)

Recent systematic reviews

How does the cam morphology develop in athletes? A systematic review and meta-analysis.

Pettit M, Doran C, Singh Y, Saito M, Sunil Kumar KH, Khanduja V
Osteoarthritis Cartilage 2021 Aug;29(8):1117-1129. Epub 2021 May 11 doi: 10.1016/j.joca.2021.02.572. PMID: 33989785

Chondrosarcomas of the hands and feet: A case series and systematic review of the literature.

Fayad LM, Ahlawat S, Khan MS, McCarthy E
Eur J Radiol 2015 Oct;84(10):2004-12. Epub 2015 Jul 2 doi: 10.1016/j.ejrad.2015.06.026. PMID: 26189572

What Is the Association Between Sports Participation and the Development of Proximal Femoral Cam Deformity? A Systematic Review and Meta-analysis.

Nepple JJ, Vigdorchik JM, Clohisy JC
Am J Sports Med 2015 Nov;43(11):2833-40. Epub 2015 Jan 13 doi: 10.1177/0363546514563909. PMID: 25587186

The prevalence of Os acromiale: a systematic review and meta-analysis.

Yammine K
Clin Anat 2014 May;27(4):610-21. Epub 2013 Dec 2 doi: 10.1002/ca.22343. PMID: 24302513

Hip ontogenesis: how evolution, genes, and load history shape hip morphotype and cartilotype.

Hogervorst T, Eilander W, Fikkers JT, Meulenbelt I
Clin Orthop Relat Res 2012 Dec;470(12):3284-96. doi: 10.1007/s11999-012-2511-4. PMID: 22926490 Free PMC Article

See all (9)

MedGen

National Center for Biotechnology Information

Send to:

Abnormal epiphysis morphology

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Genetic Testing Registry

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity