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Sclerosis of hand bone

MedGen UID:
867321
•Concept ID:
C4021684
•
Disease or Syndrome
Synonyms: Generalised sclerosis of hand bones; Generalized sclerosis of hand bones; Hand bone sclerosis; Increased bone density in hand bone; Increased bone density in hand bones
 
HPO: HP:0004054

Definition

Osteosclerosis affecting one or more bones of the hand. [from HPO]

Conditions with this feature

Dysosteosclerosis
MedGen UID:
98150
•Concept ID:
C0432262
•
Disease or Syndrome
A rare genetic primary bone dysplasia disease characterized by progressive osteosclerosis and platyspondyly.
See: Condition Record
Dysosteosclerosis

Professional guidelines

PubMed

Midkine: an emerging target of drug development for treatment of multiple diseases.
Muramatsu T, Kadomatsu K
Br J Pharmacol 2014 Feb;171(4):811-3. doi: 10.1111/bph.12571. PMID: 24460672Free PMC Article
Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis.
Botzoris V, Drosos AA
Joint Bone Spine 2011 Jul;78(4):341-6. Epub 2010 Dec 22 doi: 10.1016/j.jbspin.2010.11.005. PMID: 21183379
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Recent clinical studies

Etiology

A Quantitative Analysis of Subchondral Bone Density Around Osteochondritis Dissecans Lesions of the Capitellum.
Miyamura S, Lans J, Shimada K, Murase T, Chen NC
J Hand Surg Am 2022 Aug;47(8):790.e1-790.e11. Epub 2021 Aug 25 doi: 10.1016/j.jhsa.2021.06.020. PMID: 34452800
Avascular Necrosis of the Carpal Bones Other Than Kienböck Disease.
Afshar A, Tabrizi A
J Hand Surg Am 2020 Feb;45(2):148-152. Epub 2019 Oct 1 doi: 10.1016/j.jhsa.2019.05.022. PMID: 31585747
Acro-osteolysis.
Botou A, Bangeas A, Alexiou I, Sakkas LI
Clin Rheumatol 2017 Jan;36(1):9-14. Epub 2016 Oct 29 doi: 10.1007/s10067-016-3459-7. PMID: 27796661
The emerging role of endothelin-1 in the pathogenesis of subchondral bone disturbance and osteoarthritis.
Sin A, Tang W, Wen CY, Chung SK, Chiu KY
Osteoarthritis Cartilage 2015 Apr;23(4):516-24. Epub 2014 Nov 20 doi: 10.1016/j.joca.2014.11.002. PMID: 25463446
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Diagnosis

Classification and Radiographic Characterization of Kienböck Disease.
Lockwood WC, Lauder A
Hand Clin 2022 Nov;38(4):405-415. doi: 10.1016/j.hcl.2022.03.004. PMID: 36244708
A Quantitative Analysis of Subchondral Bone Density Around Osteochondritis Dissecans Lesions of the Capitellum.
Miyamura S, Lans J, Shimada K, Murase T, Chen NC
J Hand Surg Am 2022 Aug;47(8):790.e1-790.e11. Epub 2021 Aug 25 doi: 10.1016/j.jhsa.2021.06.020. PMID: 34452800
Osteopoikilosis.
Ellanti P, Clarke B, Gray J
Ir J Med Sci 2010 Dec;179(4):615-6. Epub 2010 Oct 1 doi: 10.1007/s11845-010-0595-y. PMID: 20886307
Imaging and staging of avascular osteonecroses at the wrist and hand.
Schmitt R, Heinze A, Fellner F, Obletter N, Strühn R, Bautz W
Eur J Radiol 1997 Sep;25(2):92-103. doi: 10.1016/s0720-048x(97)00065-x. PMID: 9283837
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Therapy

Avoidance of Pitfalls and Complications During Surgery for Temporal Lobe Epilepsy.
Arivazhagan A, Sinha S, Rao MB
Acta Neurochir Suppl 2023;130:109-119. doi: 10.1007/978-3-030-12887-6_14. PMID: 37548730
Radiographic signs of hook of hamate fracture: evaluation of diagnostic utility.
Spencer J, Hunt SL, Zhang C, Walter C, Everist B
Skeletal Radiol 2019 Dec;48(12):1891-1898. Epub 2019 May 27 doi: 10.1007/s00256-019-03221-0. PMID: 31134315
Management of Raynaud's phenomenon and digital ulcers in systemic sclerosis.
Botzoris V, Drosos AA
Joint Bone Spine 2011 Jul;78(4):341-6. Epub 2010 Dec 22 doi: 10.1016/j.jbspin.2010.11.005. PMID: 21183379
Immunomodulatory and anti-inflammatory effects of chondroitin sulphate.
du Souich P, García AG, Vergés J, Montell E
J Cell Mol Med 2009 Aug;13(8A):1451-63. Epub 2009 Jun 11 doi: 10.1111/j.1582-4934.2009.00826.x. PMID: 19522843Free PMC Article
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Prognosis

Associations between radiographic features, clinical features and ultrasound of thumb-base osteoarthritis: A secondary analysis of the COMBO study.
Shi Y, Fu K, Oo WM, Deveza LA, Wang X, Duong V, Robbins SR, Hunter DJ
Int J Rheum Dis 2022 Jan;25(1):38-46. Epub 2021 Nov 24 doi: 10.1111/1756-185X.14248. PMID: 34821056Free PMC Article
Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis.
Sampaio-Barros MM, Alvarenga JC, Takayama L, Assad APL, Sampaio-Barros PD, Pereira RMR
Osteoporos Int 2019 Aug;30(8):1679-1691. Epub 2019 Apr 27 doi: 10.1007/s00198-019-04965-0. PMID: 31030240
Is osteonecrosis of the lunate bone an underestimated feature of systemic sclerosis? A case series of nine patients and review of literature.
Frerix M, Kröger K, Szalay G, Müller-Ladner U, Tarner IH
Semin Arthritis Rheum 2016 Feb;45(4):446-54. Epub 2015 Aug 4 doi: 10.1016/j.semarthrit.2015.07.010. PMID: 26493463
Cellular players in angiogenesis during the course of systemic sclerosis.
Cipriani P, Marrelli A, Liakouli V, Di Benedetto P, Giacomelli R
Autoimmun Rev 2011 Aug;10(10):641-6. Epub 2011 Apr 22 doi: 10.1016/j.autrev.2011.04.016. PMID: 21549220
Treatment of systemic sclerosis.
Allanore Y, Kahan A
Joint Bone Spine 2006 Jul;73(4):363-8. Epub 2006 Jan 6 doi: 10.1016/j.jbspin.2005.12.003. PMID: 16495105

Clinical prediction guides

Associations between radiographic features, clinical features and ultrasound of thumb-base osteoarthritis: A secondary analysis of the COMBO study.
Shi Y, Fu K, Oo WM, Deveza LA, Wang X, Duong V, Robbins SR, Hunter DJ
Int J Rheum Dis 2022 Jan;25(1):38-46. Epub 2021 Nov 24 doi: 10.1111/1756-185X.14248. PMID: 34821056Free PMC Article
A Quantitative Analysis of Subchondral Bone Density Around Osteochondritis Dissecans Lesions of the Capitellum.
Miyamura S, Lans J, Shimada K, Murase T, Chen NC
J Hand Surg Am 2022 Aug;47(8):790.e1-790.e11. Epub 2021 Aug 25 doi: 10.1016/j.jhsa.2021.06.020. PMID: 34452800
Bone Mineral Density and Microstructure of the Elbow in Baseball Pitchers: An Analysis by Second-Generation HR-pQCT.
Sada K, Chiba K, Kajiyama S, Okazaki N, Yonekura A, Tomita M, Osaki M
J Clin Densitom 2020 Apr-Jun;23(2):322-328. Epub 2019 Mar 16 doi: 10.1016/j.jocd.2019.03.001. PMID: 31006601
Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Preiser's disease.
Vidal MA, Linscheid RL, Amadio PC, Dobyns JH
Ann Chir Main Memb Super 1991;10(3):227-35. doi: 10.1016/s0753-9053(05)80287-x. PMID: 1718357

Recent systematic reviews

Radiographic changes of the distal phalangeal tuft of the hands in subjects with systemic sclerosis. Systematic review.
Izquierdo YE, Calvo Páramo E, Castañeda LM, Gómez SV, Zambrano FS
Reumatol Clin (Engl Ed) 2018 Jan-Feb;14(1):20-26. Epub 2016 Oct 13 doi: 10.1016/j.reuma.2016.08.009. PMID: 27746086
Azathioprine for multiple sclerosis.
Casetta I, Iuliano G, Filippini G
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD003982. doi: 10.1002/14651858.CD003982.pub2. PMID: 17943809Free PMC Article

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