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Abnormality of the glabella

MedGen UID:
867395
•Concept ID:
C4021763
•
Anatomical Abnormality
Synonyms: Abnormality of the area between the eyebrows; Deformity of the area between the eyebrows; Glabellar abnormality; Malformation of the area between the eyebrows
 
HPO: HP:0002056

Definition

An abnormality of the glabella. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormality of the glabella

Professional guidelines

PubMed

Fine-grained facial phenotype-genotype analysis in Wolf-Hirschhorn syndrome.
Hammond P, Hannes F, Suttie M, Devriendt K, Vermeesch JR, Faravelli F, Forzano F, Parekh S, Williams S, McMullan D, South ST, Carey JC, Quarrell O
Eur J Hum Genet 2012 Jan;20(1):33-40. Epub 2011 Jul 27 doi: 10.1038/ejhg.2011.135. PMID: 21792232Free PMC Article

Recent clinical studies

Etiology

Comparison of aesthetic outcomes between open and endoscopically treated sagittal craniosynostosis.
Lepard J, Akbari SHA, Mooney J, Arynchyna A, Iii SGM, Myers RP, Grant J, Johnston JM
J Neurosurg Pediatr 2021 Jul 30;28(4):432-438. doi: 10.3171/2021.3.PEDS20894. PMID: 34330097
Three-Dimensional Analysis of the Skull Base of Individuals With Cleft Lip and Palate.
Mendes BC, Silva KM, da Silva CSV, Santaella NG, de Lima APDCB, Borba AM, Naclério-Homem MDG
J Craniofac Surg 2021 Nov-Dec 01;32(8):2706-2708. doi: 10.1097/SCS.0000000000007731. PMID: 34183626
Evaluation of the Facial Soft-Tissue Thickness in Patients With Cleft Lip and Palate.
Erdur EA, Baka ZM, Fidanboy M, Erdur O
J Craniofac Surg 2019 Sep;30(6):1706-1709. doi: 10.1097/SCS.0000000000005504. PMID: 31033758
Medium-sized congenital melanocytic nevus of the forehead, glabella and temple – surgical treatment and long-term follow-up.
Goldman A, Wollina U, Tchernev G, Chokoeva AA, Lotti T
J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):53-8. PMID: 27373136
A Novel Hypothesis of Visual Loss Secondary to Cosmetic Facial Filler Injection.
Li X, Du L, Lu JJ
Ann Plast Surg 2015 Sep;75(3):258-60. doi: 10.1097/SAP.0000000000000572. PMID: 26207560Free PMC Article

Diagnosis

Selected Orthodontic Principles for Management of Cranio-Maxillofacial Deformities.
Tremont TJ, Posnick JC
Oral Maxillofac Surg Clin North Am 2020 May;32(2):321-338. Epub 2020 Mar 5 doi: 10.1016/j.coms.2020.01.006. PMID: 32146029
Implications of Facial Asymmetry in Rhinoplasty.
Rohrich RJ, Villanueva NL, Small KH, Pezeshk RA
Plast Reconstr Surg 2017 Sep;140(3):510-516. doi: 10.1097/PRS.0000000000003606. PMID: 28841612
Medium-sized congenital melanocytic nevus of the forehead, glabella and temple – surgical treatment and long-term follow-up.
Goldman A, Wollina U, Tchernev G, Chokoeva AA, Lotti T
J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):53-8. PMID: 27373136
Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome.
Paradowska-Stolarz AM
Adv Clin Exp Med 2014 May-Jun;23(3):485-9. doi: 10.17219/acem/24111. PMID: 24979523
Cranio-metaphyseal dysplasia.
Gupta D, Sharma OP, Chaudhary AK, Gupta SK
Australas Radiol 1993 Feb;37(1):122-5. doi: 10.1111/j.1440-1673.1993.tb00032.x. PMID: 8323501

Therapy

Face-neck lifting and ancillary procedures: A series of 203 cases.
Anlatici R, Özerdem G, Demiralay S, Özerdem ÖR
Medicine (Baltimore) 2018 Sep;97(39):e12333. doi: 10.1097/MD.0000000000012333. PMID: 30278509Free PMC Article
Control of metopic emissary veins in trigonocephaly surgery. Technical note.
di Rocco F, Gleizal A, Lohkamp L, Szathmari A, Paulus C, Mottolese C
Childs Nerv Syst 2018 Dec;34(12):2481-2484. Epub 2018 Jul 27 doi: 10.1007/s00381-018-3928-1. PMID: 30054806
The efficacy of two formulations of botulinum toxin type A for masseter reduction: a split-face comparison study.
Wanitphakdeedecha R, Ungaksornpairote C, Kaewkes A, Sathaworawong A, Lektrakul N, Manuskiatti W
J Dermatolog Treat 2017 Aug;28(5):443-446. Epub 2016 Dec 6 doi: 10.1080/09546634.2016.1263382. PMID: 27884065
A Novel Hypothesis of Visual Loss Secondary to Cosmetic Facial Filler Injection.
Li X, Du L, Lu JJ
Ann Plast Surg 2015 Sep;75(3):258-60. doi: 10.1097/SAP.0000000000000572. PMID: 26207560Free PMC Article
Patient and occupational dose in neurointerventional procedures.
Kemerink GJ, Frantzen MJ, Oei K, Sluzewski M, van Rooij WJ, Wilmink J, van Engelshoven JM
Neuroradiology 2002 Jun;44(6):522-8. Epub 2002 May 3 doi: 10.1007/s00234-002-0780-4. PMID: 12070727

Prognosis

Comparison of aesthetic outcomes between open and endoscopically treated sagittal craniosynostosis.
Lepard J, Akbari SHA, Mooney J, Arynchyna A, Iii SGM, Myers RP, Grant J, Johnston JM
J Neurosurg Pediatr 2021 Jul 30;28(4):432-438. doi: 10.3171/2021.3.PEDS20894. PMID: 34330097
The tale of two genes: from next-generation sequencing to phenotype.
Rohanizadegan M, Siddharath A, Retterer K, Hung C, Bodamer O
Cold Spring Harb Mol Case Stud 2020 Apr;6(2) Epub 2020 Apr 1 doi: 10.1101/mcs.a004846. PMID: 31969346Free PMC Article
Medium-sized congenital melanocytic nevus of the forehead, glabella and temple – surgical treatment and long-term follow-up.
Goldman A, Wollina U, Tchernev G, Chokoeva AA, Lotti T
J Biol Regul Homeost Agents 2016 Apr-Jun;30(2 Suppl 2):53-8. PMID: 27373136
Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome.
Paradowska-Stolarz AM
Adv Clin Exp Med 2014 May-Jun;23(3):485-9. doi: 10.17219/acem/24111. PMID: 24979523
Medial fronto-facial capillary malformations.
Sillard L, Léauté-Labreze C, Mazereeuw-Hautier J, Viseux V, Barbarot S, Vabres P, Bessis D, Martin L, Lorette G, Berthier F, Lacour JP
J Pediatr 2011 May;158(5):836-41. Epub 2010 Dec 16 doi: 10.1016/j.jpeds.2010.11.001. PMID: 21167498

Clinical prediction guides

The biomechanics of chewing and suckling in the infant: A potential mechanism for physiologic metopic suture closure.
Haravu PN, Gonzalez M, Nathan SL, Ross CF, Panagiotopoulou O, Reid RR
PLoS Comput Biol 2023 Jun;19(6):e1011227. Epub 2023 Jun 22 doi: 10.1371/journal.pcbi.1011227. PMID: 37347795Free PMC Article
Comparison of aesthetic outcomes between open and endoscopically treated sagittal craniosynostosis.
Lepard J, Akbari SHA, Mooney J, Arynchyna A, Iii SGM, Myers RP, Grant J, Johnston JM
J Neurosurg Pediatr 2021 Jul 30;28(4):432-438. doi: 10.3171/2021.3.PEDS20894. PMID: 34330097
Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome.
Paradowska-Stolarz AM
Adv Clin Exp Med 2014 May-Jun;23(3):485-9. doi: 10.17219/acem/24111. PMID: 24979523
Medial fronto-facial capillary malformations.
Sillard L, Léauté-Labreze C, Mazereeuw-Hautier J, Viseux V, Barbarot S, Vabres P, Bessis D, Martin L, Lorette G, Berthier F, Lacour JP
J Pediatr 2011 May;158(5):836-41. Epub 2010 Dec 16 doi: 10.1016/j.jpeds.2010.11.001. PMID: 21167498
Interstitial deletion 2q14q21.
Frydman M, Steinberger J, Shabtai F, Katznelson MB, Varsano I
Am J Med Genet 1989 Dec;34(4):476-9. doi: 10.1002/ajmg.1320340405. PMID: 2624255

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