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Abnormal osteoclast count

MedGen UID:
868117
•Concept ID:
C4022508
•
Anatomical Abnormality
HPO: HP:0030327

Definition

An anomaly in the number of osteoclasts in bone tissue, bone-resorbing cells that develop from macrophages. This finding can be observed by histological examination of bone tissue. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal osteoclast count

Professional guidelines

PubMed

Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis.
Furlong MA, Motamedi K, Laskin WB, Vinh TN, Murphey M, Sweet DE, Fetsch JF
Hum Pathol 2003 Jul;34(7):670-9. doi: 10.1016/s0046-8177(03)00250-8. PMID: 12874763
Effect of calcitonin treatment on osteoclast counts in Paget's disease of bone.
Williams CP, Meachim G, Taylor WH
J Clin Pathol 1978 Dec;31(12):1212-7. doi: 10.1136/jcp.31.12.1212. PMID: 748391Free PMC Article

Recent clinical studies

Etiology

Allogenic hematopoietic stem cell transplantation in an Iranian patient with osteopetrosis caused by carbonic anhydrase II deficiency: A case report.
Shamsian BS, Momtazmanesh N, Saneifard H, Tabatabaei SMTH, Jafari M, Pour ZK, Al-Hussieni KJMR, Jamee M, Kamfar S
Pediatr Transplant 2024 May;28(3):e14689. doi: 10.1111/petr.14689. PMID: 38655726
Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis.
Zhang L, Yao Y, Tian J, Jiang W, Zhou S, Chen J, Xu T, Wu M
Clin Rheumatol 2021 Jan;40(1):341-348. Epub 2020 Jun 2 doi: 10.1007/s10067-020-05137-w. PMID: 32488768
An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
Fan X, Wang W, Li C, Tang T, Han Y, An K
Medicine (Baltimore) 2019 Apr;98(16):e15246. doi: 10.1097/MD.0000000000015246. PMID: 31008959Free PMC Article
Amyloid beta peptide is elevated in osteoporotic bone tissues and enhances osteoclast function.
Li S, Liu B, Zhang L, Rong L
Bone 2014 Apr;61:164-75. Epub 2014 Jan 26 doi: 10.1016/j.bone.2014.01.010. PMID: 24473375
Osteoprotegerin and its correlations with new markers of bone formation and bone resorption in kidney transplant recipients.
Malyszko J, Malyszko JS, Wolczynski S, Mysliwiec M
Transplant Proc 2003 Sep;35(6):2227-9. doi: 10.1016/s0041-1345(03)00755-3. PMID: 14529897

Diagnosis

Allogenic hematopoietic stem cell transplantation in an Iranian patient with osteopetrosis caused by carbonic anhydrase II deficiency: A case report.
Shamsian BS, Momtazmanesh N, Saneifard H, Tabatabaei SMTH, Jafari M, Pour ZK, Al-Hussieni KJMR, Jamee M, Kamfar S
Pediatr Transplant 2024 May;28(3):e14689. doi: 10.1111/petr.14689. PMID: 38655726
Raloxifene retards cartilage degradation and improves subchondral bone micro-architecture in ovariectomized rats with patella baja-induced - patellofemoral joint osteoarthritis.
Bei MJ, Tian FM, Xiao YP, Cao XH, Liu N, Zheng ZY, Dai MW, Wang WY, Song HP, Zhang L
Osteoarthritis Cartilage 2020 Mar;28(3):344-355. Epub 2019 Jul 18 doi: 10.1016/j.joca.2019.06.014. PMID: 31326553
An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
Fan X, Wang W, Li C, Tang T, Han Y, An K
Medicine (Baltimore) 2019 Apr;98(16):e15246. doi: 10.1097/MD.0000000000015246. PMID: 31008959Free PMC Article
Bone alkaline phosphatase isoforms in hemodialysis patients with low versus non-low bone turnover: a diagnostic test study.
Haarhaus M, Monier-Faugere MC, Magnusson P, Malluche HH
Am J Kidney Dis 2015 Jul;66(1):99-105. Epub 2015 Apr 2 doi: 10.1053/j.ajkd.2015.02.323. PMID: 25843703Free PMC Article
Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis.
Furlong MA, Motamedi K, Laskin WB, Vinh TN, Murphey M, Sweet DE, Fetsch JF
Hum Pathol 2003 Jul;34(7):670-9. doi: 10.1016/s0046-8177(03)00250-8. PMID: 12874763

Therapy

Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
The calcineurin inhibitor tacrolimus as a new therapy in severe cherubism.
Kadlub N, Vazquez MP, Galmiche L, L'Herminé AC, Dainese L, Ulinski T, Fauroux B, Pavlov I, Badoual C, Marlin S, Deckert M, Leboulanger N, Berdal A, Descroix V, Picard A, Coudert AE
J Bone Miner Res 2015 May;30(5):878-85. doi: 10.1002/jbmr.2431. PMID: 25491283
Comparative effects of clodronate and calcitonin on bone in metastatic breast cancer: a histomorphometric study.
Taube T, Elomaa I, Blomqvist C, Beneton MN, Kanis JA
Eur J Cancer 1993;29A(12):1677-81. doi: 10.1016/0959-8049(93)90103-m. PMID: 8398293
The effect of 1,25 (OH)2D3 on bone mineralization: ultrastructural studies in patients with renal osteodystrophy.
Krempien B, Ritz E, Tschöpe W
Contrib Nephrol 1980;18:122-34. doi: 10.1159/000403279. PMID: 7353371
Effect of calcitonin treatment on osteoclast counts in Paget's disease of bone.
Williams CP, Meachim G, Taylor WH
J Clin Pathol 1978 Dec;31(12):1212-7. doi: 10.1136/jcp.31.12.1212. PMID: 748391Free PMC Article

Prognosis

Allogenic hematopoietic stem cell transplantation in an Iranian patient with osteopetrosis caused by carbonic anhydrase II deficiency: A case report.
Shamsian BS, Momtazmanesh N, Saneifard H, Tabatabaei SMTH, Jafari M, Pour ZK, Al-Hussieni KJMR, Jamee M, Kamfar S
Pediatr Transplant 2024 May;28(3):e14689. doi: 10.1111/petr.14689. PMID: 38655726
An osteoclast-like giant cell tumor embedded in the mural nodule of a pancreatic mucinous cystic neoplasm: A case report and literature review.
Fan X, Wang W, Li C, Tang T, Han Y, An K
Medicine (Baltimore) 2019 Apr;98(16):e15246. doi: 10.1097/MD.0000000000015246. PMID: 31008959Free PMC Article
Synovial-type giant cell tumors of the vertebral column: a clinicopathologic study of 15 cases, with a review of the literature and discussion of the differential diagnosis.
Furlong MA, Motamedi K, Laskin WB, Vinh TN, Murphey M, Sweet DE, Fetsch JF
Hum Pathol 2003 Jul;34(7):670-9. doi: 10.1016/s0046-8177(03)00250-8. PMID: 12874763
Multiple organ failure associated with extensive metastatic calcification in a patient with an intermediate state of human T lymphotropic virus type I (HTLV-I) infection: report of an autopsy case.
Kumamoto H, Ichinohasama R, Sawai T, Naganuma H, Furukawa Y, Akiu N, Kano M, Ooya K
Pathol Int 1998 Apr;48(4):313-8. doi: 10.1111/j.1440-1827.1998.tb03912.x. PMID: 9648162
Studies of bone morphology, bone densitometry and laboratory data in patients on maintenance hemodialysis treatment.
Lindergård B, Johnell O, Nilsson BE, Wiklund PE
Nephron 1985;39(2):122-9. doi: 10.1159/000183355. PMID: 3974774

Clinical prediction guides

Alterations and abnormal expression of A20 in peripheral monocyte subtypes in patients with rheumatoid arthritis.
Zhang L, Yao Y, Tian J, Jiang W, Zhou S, Chen J, Xu T, Wu M
Clin Rheumatol 2021 Jan;40(1):341-348. Epub 2020 Jun 2 doi: 10.1007/s10067-020-05137-w. PMID: 32488768
Negative Regulation of Osteoclast Commitment by Intracellular Protein Phosphatase Magnesium-Dependent 1A.
Kwon OC, Choi B, Lee EJ, Park JE, Lee EJ, Kim EY, Kim SM, Shin MK, Kim TH, Hong S, Lee CK, Yoo B, Robinson WH, Kim YG, Chang EJ
Arthritis Rheumatol 2020 May;72(5):750-760. Epub 2020 Mar 30 doi: 10.1002/art.41180. PMID: 31762216
Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate-Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry.
Ramalho J, Martins CSW, Galvão J, Furukawa LN, Domingues WV, Oliveira IB, Dos Reis LM, Pereira RM, Nickolas TL, Yin MT, Eira M, Jorgetti V, Moyses RM
J Bone Miner Res 2019 Sep;34(9):1574-1584. Epub 2019 Jul 3 doi: 10.1002/jbmr.3751. PMID: 31269294Free PMC Article
Phenotypic Spectrum in Osteogenesis Imperfecta Due to Mutations in TMEM38B: Unraveling a Complex Cellular Defect.
Webb EA, Balasubramanian M, Fratzl-Zelman N, Cabral WA, Titheradge H, Alsaedi A, Saraff V, Vogt J, Cole T, Stewart S, Crabtree NJ, Sargent BM, Gamsjaeger S, Paschalis EP, Roschger P, Klaushofer K, Shaw NJ, Marini JC, Högler W
J Clin Endocrinol Metab 2017 Jun 1;102(6):2019-2028. doi: 10.1210/jc.2016-3766. PMID: 28323974Free PMC Article
Bone-bound bisphosphonate inhibits growth of adjacent non-bone cells.
Cornish J, Bava U, Callon KE, Bai J, Naot D, Reid IR
Bone 2011 Oct;49(4):710-6. Epub 2011 Jul 23 doi: 10.1016/j.bone.2011.07.020. PMID: 21807133

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