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Large-cell immunoblastic lymphoma

MedGen UID:
86955
•Concept ID:
C0079746
•
Neoplastic Process
Synonyms: Diffuse Immunoblastic Lymphosarcoma; Diffuse Immunoblastic Lymphosarcomas; Immunoblastic Large Cell Lymphoma; Immunoblastic Large-Cell Lymphoma; Immunoblastic Large-Cell Lymphomas; Immunoblastic Lymphoma, Large-Cell; Immunoblastic Lymphomas, Large-Cell; Immunoblastic Lymphosarcoma, Diffuse; Immunoblastic Lymphosarcomas, Diffuse; Immunoblastic Sarcoma; Immunoblastic Sarcomas; Immunoblastoma; Immunoblastomas; Large Cell Immunoblastic Lymphoma; Large-Cell Immunoblastic Lymphoma; Large-Cell Immunoblastic Lymphomas; Large-Cell Lymphoma, Immunoblastic; Large-Cell Lymphomas, Immunoblastic; Lymphoma, Immunoblastic Large-Cell; Lymphoma, Immunoblastic, Large Cell; Lymphoma, Immunoblastic, Large-Cell; Lymphoma, Large Cell, Immunoblastic; Lymphoma, Large-Cell Immunoblastic; Lymphoma, Large-Cell, Immunoblastic; Lymphomas, Immunoblastic Large-Cell; Lymphomas, Large-Cell Immunoblastic; Lymphosarcoma, Diffuse Immunoblastic; Lymphosarcomas, Diffuse Immunoblastic; Sarcoma, Immunoblastic; Sarcomas, Immunoblastic
SNOMED CT: Malignant lymphoma - immunoblastic (109966003); Diffuse non-Hodgkin's immunoblastic (diffuse) lymphoma (109966003); Immunoblastic malignant lymphoma - large cell (109966003); Diffuse non-Hodgkin's lymphoma, immunoblastic (clinical) (109966003); Diffuse non-Hodgkin's lymphoma, immunoblastic (109966003); Diffuse non-Hodgkin lymphoma, immunoblastic (109966003); Lymphoma, immunoblastic, high grade (109966003)
 
Monarch Initiative: MONDO:0022037

Definition

A diffuse large B-cell lymphoma characterized by the presence of immunoblasts with uniformly round-to-oval nuclei, a prominent nucleolus, and abundant cytoplasm. [from NCI]

Professional guidelines

PubMed

T-Cell Lymphomas, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
Horwitz SM, Ansell S, Ai WZ, Barnes J, Barta SK, Brammer J, Clemens MW, Dogan A, Foss F, Ghione P, Goodman AM, Guitart J, Halwani A, Haverkos BM, Hoppe RT, Jacobsen E, Jagadeesh D, Jones A, Kallam A, Kim YH, Kumar K, Mehta-Shah N, Olsen EA, Rajguru SA, Rozati S, Said J, Shaver A, Shea L, Shinohara MM, Sokol L, Torres-Cabala C, Wilcox R, Wu P, Zain J, Dwyer M, Sundar H
J Natl Compr Canc Netw 2022 Mar;20(3):285-308. doi: 10.6004/jnccn.2022.0015. PMID: 35276674
Plasmablastic Lymphoma: A Review of Clinicopathologic Features and Differential Diagnosis.
Harmon CM, Smith LB
Arch Pathol Lab Med 2016 Oct;140(10):1074-8. doi: 10.5858/arpa.2016-0232-RA. PMID: 27684979
Clinical practice guidelines: non-Hodgkin's lymphomas.
Fisher RI, Oken MM
Cleve Clin J Med 1995;62 Suppl 1:SI6-42, quiz SI43-5. PMID: 7641398

Recent clinical studies

Etiology

Primary effusion lymphoma: a distinct clinicopathologic entity associated with the Kaposi's sarcoma-associated herpes virus.
Nador RG, Cesarman E, Chadburn A, Dawson DB, Ansari MQ, Sald J, Knowles DM
Blood 1996 Jul 15;88(2):645-56. PMID: 8695812
Optimal primer selection for clonality assessment by polymerase chain reaction analysis. III. Intermediate and high-grade B-cell neoplasms.
Lombardo JF, Hwang TS, Maiese RL, Millson A, Segal GH
Hum Pathol 1996 Apr;27(4):373-80. doi: 10.1016/s0046-8177(96)90111-2. PMID: 8617481
Malignant lymphomas involving the ovary. A clinicopathologic analysis of 39 cases.
Monterroso V, Jaffe ES, Merino MJ, Medeiros LJ
Am J Surg Pathol 1993 Feb;17(2):154-70. doi: 10.1097/00000478-199302000-00007. PMID: 8422111
Relapsing large cell immunoblastic lymphoma complicating well-differentiated lymphocytic lymphoma: a report of two cases showing prolonged survival with therapy.
Kennedy MJ, Daly PA, Lawlor E, O'Briain DS
Clin Lab Haematol 1988;10(1):7-14. doi: 10.1111/j.1365-2257.1988.tb01147.x. PMID: 3284695
Recurrent chromosome abnormalities in adult T-cell lymphomas of peripheral T-cell origin.
Fujita K, Fukuhara S, Nasu K, Yamabe H, Tomono N, Inamoto Y, Shimazaki C, Ohno H, Doi S, Kamesaki H
Int J Cancer 1986 Apr 15;37(4):517-24. doi: 10.1002/ijc.2910370408. PMID: 3485582

Diagnosis

Anaplastic large-cell lymphoma (Ki-1 lymphoma) and diffuse large-cell immunoblastic lymphoma: two diagnostic problem cases.
King JA, Martino RL, Tucker JA
Ultrastruct Pathol 1998 Jan-Feb;22(1):55-62. doi: 10.3109/01913129809032258. PMID: 9491216
Epstein-Bar virus and progression of non-Hodgkin's lymphoma to Ki-1-positive, anaplastic large cell phenotype.
DiGiuseppe JA, Wu TC, Zehnbauer BA, McDowell PR, Barletta JM, Ambinder RF, Mann RB
Mod Pathol 1995 Jun;8(5):553-9. PMID: 7675777
Combined chemotherapy and radiotherapy in diffuse large cell immunoblastic lymphoma: a phase II study of CHOP/bleomycin/methotrexate alternating with ifosfamide/methotrexate/etoposide.
Rodriguez JM, Khan AA
Clin Oncol (R Coll Radiol) 1995;7(2):113-6. doi: 10.1016/s0936-6555(05)80813-1. PMID: 7542471
Detection and characterization of Epstein-Barr virus in clinical specimens.
Ambinder RF, Mann RB
Am J Pathol 1994 Aug;145(2):239-52. PMID: 8053485Free PMC Article
Endobronchial HIV associated lymphoma.
Keys TC, Judson MA, Reed CE, Sahn SA
Thorax 1994 May;49(5):525-6. doi: 10.1136/thx.49.5.525. PMID: 8016780Free PMC Article

Therapy

A predictive model for life-threatening neutropenia and febrile neutropenia after the first course of CHOP chemotherapy in patients with aggressive non-Hodgkin's lymphoma.
Intragumtornchai T, Sutheesophon J, Sutcharitchan P, Swasdikul D
Leuk Lymphoma 2000 Apr;37(3-4):351-60. doi: 10.3109/10428190009089435. PMID: 10752986
Primary malignant lymphoma of the duodenum: report of a case.
Shibata Y, Niwa M, Sone S, Nagayama S, Uesaka Y, Miura I
Hepatogastroenterology 1998 Nov-Dec;45(24):2171-4. PMID: 9951887
Combined chemotherapy and radiotherapy in diffuse large cell immunoblastic lymphoma: a phase II study of CHOP/bleomycin/methotrexate alternating with ifosfamide/methotrexate/etoposide.
Rodriguez JM, Khan AA
Clin Oncol (R Coll Radiol) 1995;7(2):113-6. doi: 10.1016/s0936-6555(05)80813-1. PMID: 7542471
The spectrum of human immunodeficiency virus infection in patients with factor IX deficiency (Christmas disease).
Goldsmith JM, Variakojis D, Phair JP, Green D
Am J Hematol 1987 Jun;25(2):203-10. doi: 10.1002/ajh.2830250210. PMID: 3037883
Malignant lymphoma, diffuse mixed small and large cell. A clinicopathologic study of 47 cases.
Foucar K, Armitage JO, Dick FR
Cancer 1983 Jun 1;51(11):2090-9. doi: 10.1002/1097-0142(19830601)51:11<2090::aid-cncr2820511123>3.0.co;2-g. PMID: 6687699

Prognosis

B-cell chronic lymphocytic leukemia followed by high grade T-cell lymphoma. An unusual variant of Richter's syndrome.
Lee A, Skelly ME, Kingma DW, Medeiros LJ
Am J Clin Pathol 1995 Mar;103(3):348-52. doi: 10.1093/ajcp/103.3.348. PMID: 7872259
Epstein-Bar virus and progression of non-Hodgkin's lymphoma to Ki-1-positive, anaplastic large cell phenotype.
DiGiuseppe JA, Wu TC, Zehnbauer BA, McDowell PR, Barletta JM, Ambinder RF, Mann RB
Mod Pathol 1995 Jun;8(5):553-9. PMID: 7675777
Malignant lymphomas involving the ovary. A clinicopathologic analysis of 39 cases.
Monterroso V, Jaffe ES, Merino MJ, Medeiros LJ
Am J Surg Pathol 1993 Feb;17(2):154-70. doi: 10.1097/00000478-199302000-00007. PMID: 8422111
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Kossakowska AE, Urbanski SJ, Huchcroft SA, Edwards DR
Oncol Res 1992;4(6):233-40. PMID: 1421616
Relapsing large cell immunoblastic lymphoma complicating well-differentiated lymphocytic lymphoma: a report of two cases showing prolonged survival with therapy.
Kennedy MJ, Daly PA, Lawlor E, O'Briain DS
Clin Lab Haematol 1988;10(1):7-14. doi: 10.1111/j.1365-2257.1988.tb01147.x. PMID: 3284695

Clinical prediction guides

Optimal primer selection for clonality assessment by polymerase chain reaction analysis. III. Intermediate and high-grade B-cell neoplasms.
Lombardo JF, Hwang TS, Maiese RL, Millson A, Segal GH
Hum Pathol 1996 Apr;27(4):373-80. doi: 10.1016/s0046-8177(96)90111-2. PMID: 8617481
Epstein-Barr virus and primary lung lymphoma: a study utilizing the polymerase chain reaction.
Hytiroglou P, Strauchen JA, Vrettou E, Papadimitriou CS, Fasy TM, Morgello S
Mod Pathol 1993 Sep;6(5):575-80. PMID: 8248115
Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.
Kossakowska AE, Urbanski SJ, Huchcroft SA, Edwards DR
Oncol Res 1992;4(6):233-40. PMID: 1421616
AIDS-associated polyclonal lymphoma: identification of a new HIV-associated disease process.
McGrath MS, Shiramizu B, Meeker TC, Kaplan LD, Herndier B
J Acquir Immune Defic Syndr (1988) 1991;4(4):408-15. PMID: 1848889
Recurrent chromosome abnormalities in adult T-cell lymphomas of peripheral T-cell origin.
Fujita K, Fukuhara S, Nasu K, Yamabe H, Tomono N, Inamoto Y, Shimazaki C, Ohno H, Doi S, Kamesaki H
Int J Cancer 1986 Apr 15;37(4):517-24. doi: 10.1002/ijc.2910370408. PMID: 3485582

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