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Punctate palmar hyperkeratosis

MedGen UID:
870412
Concept ID:
C4024857
Disease or Syndrome
HPO: HP:0007508

Definition

Tiny bumps of thickened skin (hyperkeratosis) on the palms of the hands. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPunctate palmar hyperkeratosis

Conditions with this feature

Diffuse idiopathic skeletal hyperostosis
MedGen UID:
5695
Concept ID:
C0020498
Disease or Syndrome
A rare dysostosis with predominant vertebral involvement characterized by paraspinal ligament ossification (most pronounced in the lower thoracic region), osteophytosis, marginal sacroiliac joint sclerosis, and punctate hyperkeratosis on the soles and palms. Patients may be asymptomatic or present mild to moderate back pain. There have been no further descriptions in the literature since 1969.

Recent clinical studies

Etiology

Lovgren ML, McAleer MA, Irvine AD, Wilson NJ, Tavadia S, Schwartz ME, Cole C, Sandilands A, Smith FJD, Zamiri M
Br J Dermatol 2017 May;176(5):1345-1350. Epub 2017 Apr 2 doi: 10.1111/bjd.14973. PMID: 27534273Free PMC Article
Rustad OJ, Vance JC
J Am Acad Dermatol 1990 Mar;22(3):468-76. doi: 10.1016/0190-9622(90)70066-q. PMID: 2138179

Diagnosis

Valek SA, Ahmad AS, Rousseau MA, Rashid RM
J Cutan Pathol 2023 Apr;50(4):371-377. Epub 2023 Feb 6 doi: 10.1111/cup.14392. PMID: 36640046
Alejo A, Castellanos-Angarita A, Arias L, Mejía M, Charry L
Skinmed 2021;19(4):310-312. Epub 2021 Aug 1 PMID: 34526209
Haag C, Lucero OM, Fett NM
J Clin Rheumatol 2021 Mar 1;27(2):e47-e49. doi: 10.1097/RHU.0000000000000849. PMID: 29965855
Patel S, Zirwas M, English JC 3rd
Am J Clin Dermatol 2007;8(1):1-11. doi: 10.2165/00128071-200708010-00001. PMID: 17298101
Rustad OJ, Vance JC
J Am Acad Dermatol 1990 Mar;22(3):468-76. doi: 10.1016/0190-9622(90)70066-q. PMID: 2138179

Therapy

Haag C, Lucero OM, Fett NM
J Clin Rheumatol 2021 Mar 1;27(2):e47-e49. doi: 10.1097/RHU.0000000000000849. PMID: 29965855
Lowes MA, Khaira GS, Holt D
Australas J Dermatol 2000 Aug;41(3):172-4. doi: 10.1046/j.1440-0960.2000.00424.x. PMID: 10954989

Prognosis

Rustad OJ, Vance JC
J Am Acad Dermatol 1990 Mar;22(3):468-76. doi: 10.1016/0190-9622(90)70066-q. PMID: 2138179

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