U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal cervical myelogram

MedGen UID:
870681
Concept ID:
C4025135
Anatomical Abnormality
HPO: HP:0005788

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal cervical myelogram

Conditions with this feature

Primary basilar invagination
MedGen UID:
400018
Concept ID:
C1862299
Disease or Syndrome
Primary basilar impression of the skull is a developmental defect of the cranium in which there is invagination of the foramen magnum upward into the posterior cranial fossa. Basilar impression is often associated with other malformations of the notochord and craniovertebral junction, such as occipitalization of the atlas, Klippel-Feil anomaly (see 118100), Chiari type I malformation (118420), and syringomyelia (186700) (Paradis and Sax, 1972; Bhangoo and Crockard, 1999). Secondary basilar impression occurs as a result of generalized skeletal diseases, including hyperparathyroidism (see 145000), Paget disease (see 167250), and osteogenesis imperfecta (see, e.g., 166200). Platybasia refers to a skull base with an abnormally obtuse angle between the planes of the clivus and the anterior fossa. Platybasia may occur in basilar impression, but it is not of medical significance on its own (Bhangoo and Crockard, 1999). Historically, basilar impression was defined radiologically by numerous parameters, including the lines defined by Chamberlain (1939), McGregor (1948), and Fischgold and Metzger (1952), and the angle defined by Bull et al. (1955).

Professional guidelines

PubMed

Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269
Emery SE
J Am Acad Orthop Surg 2001 Nov-Dec;9(6):376-88. doi: 10.5435/00124635-200111000-00003. PMID: 11767723
Vanichkachorn JS, Vaccaro AR
J Am Acad Orthop Surg 2000 May-Jun;8(3):159-69. doi: 10.5435/00124635-200005000-00003. PMID: 10874223

Recent clinical studies

Etiology

Heiss JD, Snyder K, Peterson MM, Patronas NJ, Butman JA, Smith RK, Devroom HL, Sansur CA, Eskioglu E, Kammerer WA, Oldfield EH
J Neurosurg Spine 2012 Nov;17(5):367-80. Epub 2012 Sep 7 doi: 10.3171/2012.8.SPINE111059. PMID: 22958075Free PMC Article
Gordon N
Dev Med Child Neurol 2009 Dec;51(12):932-5. doi: 10.1111/j.1469-8749.2009.03514.x. PMID: 19909307
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269
Emery SE
J Am Acad Orthop Surg 2001 Nov-Dec;9(6):376-88. doi: 10.5435/00124635-200111000-00003. PMID: 11767723
Pang D, Dias MS
Neurosurgery 1993 Sep;33(3):363-72; discussion 372-3. doi: 10.1227/00006123-199309000-00003. PMID: 8413865

Diagnosis

Gordon N
Dev Med Child Neurol 2009 Dec;51(12):932-5. doi: 10.1111/j.1469-8749.2009.03514.x. PMID: 19909307
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269
Emery SE
J Am Acad Orthop Surg 2001 Nov-Dec;9(6):376-88. doi: 10.5435/00124635-200111000-00003. PMID: 11767723
Jacobs B
N Y State J Med 1990 Jan;90(1):8-11. PMID: 2296405
Giménez-Roldán S, Benito C, Mateo D
J Neurol Sci 1978 Mar;36(1):135-46. doi: 10.1016/0022-510x(78)90167-3. PMID: 650252

Therapy

Taylor MN, Tambi S, Almeida ND, Housley SB, Reynolds RM
World Neurosurg 2022 Aug;164:156-158. Epub 2022 May 4 doi: 10.1016/j.wneu.2022.04.117. PMID: 35525438
Heiss JD, Snyder K, Peterson MM, Patronas NJ, Butman JA, Smith RK, Devroom HL, Sansur CA, Eskioglu E, Kammerer WA, Oldfield EH
J Neurosurg Spine 2012 Nov;17(5):367-80. Epub 2012 Sep 7 doi: 10.3171/2012.8.SPINE111059. PMID: 22958075Free PMC Article
Chin KR, Eiszner JR, Huang JL, Huang JI, Roh JS, Bohlman HH
J Spinal Disord Tech 2008 Jul;21(5):334-7. doi: 10.1097/BSD.0b013e3181506780. PMID: 18600143
Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269
Jinkins JR, Bashir R, Al-Mefty O, Al-Kawi MZ, Fox JL
Lancet 1977 Sep 3;2(8036):487-8. PMID: 70693Free PMC Article

Prognosis

Epstein N
Spine J 2002 Nov-Dec;2(6):436-49. doi: 10.1016/s1529-9430(02)00394-7. PMID: 14589269
Emery SE
J Am Acad Orthop Surg 2001 Nov-Dec;9(6):376-88. doi: 10.5435/00124635-200111000-00003. PMID: 11767723
Vanichkachorn JS, Vaccaro AR
J Am Acad Orthop Surg 2000 May-Jun;8(3):159-69. doi: 10.5435/00124635-200005000-00003. PMID: 10874223
Wilmink JT
Eur Radiol 1999;9(7):1259-66. doi: 10.1007/s003300050832. PMID: 10460358
Pang D, Dias MS
Neurosurgery 1993 Sep;33(3):363-72; discussion 372-3. doi: 10.1227/00006123-199309000-00003. PMID: 8413865

Clinical prediction guides

Laohaprasitiporn P, Wongtrakul S, Vathana T, Limthongthang R, Songcharoen P
J Hand Surg Asian Pac Vol 2018 Sep;23(3):360-363. doi: 10.1142/S2424835518500376. PMID: 30282542
Kim WJ, Shin HY, Kim YC, Moon JY
J Neurosurg Anesthesiol 2016 Apr;28(2):147-52. doi: 10.1097/ANA.0000000000000259. PMID: 26649768
Song KJ, Choi BW, Kim GH, Kim JR
J Spinal Disord Tech 2009 Jul;22(5):353-7. doi: 10.1097/BSD.0b013e31817df78e. PMID: 19525791
Naderi S, Ozgen S, Pamir MN, Ozek MM, Erzen C
Neurosurgery 1998 Jul;43(1):43-9; discussion 49-50. doi: 10.1097/00006123-199807000-00028. PMID: 9657187
Pang D
Neurosurgery 1992 Sep;31(3):481-500. doi: 10.1227/00006123-199209000-00011. PMID: 1407429

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...