U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal skull base morphology

MedGen UID:
871209
•Concept ID:
C4025688
•
Anatomical Abnormality
Synonyms: Abnormality of cranial base; Abnormality of the skull base
 
HPO: HP:0002693

Definition

An abnormality of the base of the skull, which forms the floor of the cranial cavity and separates the brain from other facial structures. The skull base is made up of five bones [from HPO]

Professional guidelines

PubMed

Surgical management of cerebral dural arteriovenous fistulae.
Rutkowski MJ, Jian B, Lawton MT
Handb Clin Neurol 2017;143:107-116. doi: 10.1016/B978-0-444-63640-9.00010-2. PMID: 28552132
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183
Chiari Type 1 Deformity in Children: Pathogenetic, Clinical, Neuroimaging, and Management Aspects.
Poretti A, Ashmawy R, Garzon-Muvdi T, Jallo GI, Huisman TA, Raybaud C
Neuropediatrics 2016 Oct;47(5):293-307. Epub 2016 Jun 23 doi: 10.1055/s-0036-1584563. PMID: 27337547

Recent clinical studies

Etiology

Central Skull Base Osteomyelitis: Multimodality Imaging and Clinical Findings from a Large Indian Cohort.
Maramattom BV, Ram SA, Viswam V, Nair S
Neurol India 2022 Sep-Oct;70(5):1911-1919. doi: 10.4103/0028-3886.359218. PMID: 36352587
Refining the Neuroimaging Definition of the Dandy-Walker Phenotype.
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
Skull base osteomyelitis: clinical and radiologic analysis of a rare and multifaceted pathological entity.
Schreiber A, Ravanelli M, Rampinelli V, Ferrari M, Vural A, Mattavelli D, Mataj E, Mazza V, Zorza I, Bonù ML, Signorini L, Chiari E, Sorrentino T, Doglietto F, Farina D, Maroldi R, Nicolai P
Neurosurg Rev 2021 Feb;44(1):555-569. Epub 2020 Feb 8 doi: 10.1007/s10143-020-01254-x. PMID: 32036506
Choanal Atresia and Other Neonatal Nasal Anomalies.
Rajan R, Tunkel DE
Clin Perinatol 2018 Dec;45(4):751-767. Epub 2018 Sep 18 doi: 10.1016/j.clp.2018.07.011. PMID: 30396416
Partial midfacial duplication.
Shen W, Cui J, Chen J, Ji Y, Zou J, Chen H, Xiongzheng M
J Craniofac Surg 2013 May;24(3):934-6. doi: 10.1097/SCS.0b013e31828606a1. PMID: 23714914

Diagnosis

Refining the Neuroimaging Definition of the Dandy-Walker Phenotype.
Whitehead MT, Barkovich MJ, Sidpra J, Alves CA, Mirsky DM, Öztekin Ö, Bhattacharya D, Lucato LT, Sudhakar S, Taranath A, Andronikou S, Prabhu SP, Aldinger KA, Haldipur P, Millen KJ, Barkovich AJ, Boltshauser E, Dobyns WB, Mankad K
AJNR Am J Neuroradiol 2022 Oct;43(10):1488-1493. Epub 2022 Sep 22 doi: 10.3174/ajnr.A7659. PMID: 36137655Free PMC Article
Imaging of the Central Skull Base.
Conley LM, Phillips CD
Radiol Clin North Am 2017 Jan;55(1):53-67. doi: 10.1016/j.rcl.2016.08.007. PMID: 27890188
Skull base development and craniosynostosis.
Blaser SI, Padfield N, Chitayat D, Forrest CR
Pediatr Radiol 2015 Sep;45 Suppl 3:S485-96. Epub 2015 Sep 7 doi: 10.1007/s00247-015-3320-1. PMID: 26346154
Spontaneous CSF Leaks.
Wang EW, Vandergrift WA 3rd, Schlosser RJ
Otolaryngol Clin North Am 2011 Aug;44(4):845-56, vii. doi: 10.1016/j.otc.2011.06.018. PMID: 21819875
Neurocutaneous vascular syndromes.
Puttgen KB, Lin DD
Childs Nerv Syst 2010 Oct;26(10):1407-15. Epub 2010 Jun 27 doi: 10.1007/s00381-010-1201-3. PMID: 20582592

Therapy

Pycnodysostosis at otorhinolaryngology.
Baglam T, Binnetoglu A, Fatih Topuz M, Baş Ikizoglu N, Ersu R, Turan S, Sarı M
Int J Pediatr Otorhinolaryngol 2017 Apr;95:91-96. Epub 2017 Feb 11 doi: 10.1016/j.ijporl.2017.02.009. PMID: 28576543
Anterocollis and anterocaput.
Finsterer J, Revuelta GJ
Clin Neurol Neurosurg 2014 Dec;127:44-53. Epub 2014 Oct 2 doi: 10.1016/j.clineuro.2014.09.020. PMID: 25459242
Spontaneous CSF Leaks.
Wang EW, Vandergrift WA 3rd, Schlosser RJ
Otolaryngol Clin North Am 2011 Aug;44(4):845-56, vii. doi: 10.1016/j.otc.2011.06.018. PMID: 21819875
Spontaneous intracranial hypotension.
Mokri B
Curr Neurol Neurosci Rep 2001 Mar;1(2):109-17. doi: 10.1007/s11910-001-0005-y. PMID: 11898506
Spontaneous intracranial hypotension.
Mokri B
Curr Pain Headache Rep 2001 Jun;5(3):284-91. doi: 10.1007/s11916-001-0045-7. PMID: 11309218

Prognosis

Dandy-Walker Malformation.
Society for Maternal-Fetal Medicine (SMFM), Monteagudo A
Am J Obstet Gynecol 2020 Dec;223(6):B38-B41. Epub 2020 Nov 7 doi: 10.1016/j.ajog.2020.08.184. PMID: 33168220
Skull base development and craniosynostosis.
Blaser SI, Padfield N, Chitayat D, Forrest CR
Pediatr Radiol 2015 Sep;45 Suppl 3:S485-96. Epub 2015 Sep 7 doi: 10.1007/s00247-015-3320-1. PMID: 26346154
Congenital abnormalities of the posterior fossa.
Bosemani T, Orman G, Boltshauser E, Tekes A, Huisman TA, Poretti A
Radiographics 2015 Jan-Feb;35(1):200-20. doi: 10.1148/rg.351140038. PMID: 25590398
Partial midfacial duplication.
Shen W, Cui J, Chen J, Ji Y, Zou J, Chen H, Xiongzheng M
J Craniofac Surg 2013 May;24(3):934-6. doi: 10.1097/SCS.0b013e31828606a1. PMID: 23714914
Hydrocephalus in Dandy-Walker malformation.
Spennato P, Mirone G, Nastro A, Buonocore MC, Ruggiero C, Trischitta V, Aliberti F, Cinalli G
Childs Nerv Syst 2011 Oct;27(10):1665-81. Epub 2011 Sep 17 doi: 10.1007/s00381-011-1544-4. PMID: 21928031

Clinical prediction guides

The foramen magnum in scaphocephaly.
Skadorwa T, Wierzbieniec O
Childs Nerv Syst 2022 Nov;38(11):2163-2170. Epub 2022 Aug 5 doi: 10.1007/s00381-022-05624-2. PMID: 35931858Free PMC Article
Comprehensive review of the mastoid foramen.
Wang C, Lockwood J, Iwanaga J, Dumont AS, Bui CJ, Tubbs RS
Neurosurg Rev 2021 Jun;44(3):1255-1258. Epub 2020 Jun 7 doi: 10.1007/s10143-020-01329-9. PMID: 32507931
Pycnodysostosis at otorhinolaryngology.
Baglam T, Binnetoglu A, Fatih Topuz M, Baş Ikizoglu N, Ersu R, Turan S, Sarı M
Int J Pediatr Otorhinolaryngol 2017 Apr;95:91-96. Epub 2017 Feb 11 doi: 10.1016/j.ijporl.2017.02.009. PMID: 28576543
Skull base development and craniosynostosis.
Blaser SI, Padfield N, Chitayat D, Forrest CR
Pediatr Radiol 2015 Sep;45 Suppl 3:S485-96. Epub 2015 Sep 7 doi: 10.1007/s00247-015-3320-1. PMID: 26346154
Neurofibromatosis and hypertelorism.
Westerhof W, Delleman JW, Wolters E, Dijkstra P
Arch Dermatol 1984 Dec;120(12):1579-81. PMID: 6439124

Recent systematic reviews

Evaluation of Long-Term Follow-Up in Ecchordosis Physaliphora versus Chordoma.
Stuebe CM, Rindler RS, Laack N, Carr CM, Choby G, Inwards CY, Van Gompel JJ
World Neurosurg 2023 Jun;174:157-168. Epub 2023 Mar 9 doi: 10.1016/j.wneu.2023.03.016. PMID: 36898627
Primary Intraosseous Cavernous Hemangioma of the Cranium: A Systematic Review of the Literature.
Alexiou GA, Lampros M, Gavra MM, Vlachos N, Ydreos J, Boviatsis EJ
World Neurosurg 2022 Aug;164:323-329. Epub 2022 May 30 doi: 10.1016/j.wneu.2022.05.107. PMID: 35654328
Craniofacial morphology in down syndrome: a systematic review and meta-analysis.
Vicente A, Bravo-González LA, López-Romero A, Muñoz CS, Sánchez-Meca J
Sci Rep 2020 Nov 16;10(1):19895. doi: 10.1038/s41598-020-76984-5. PMID: 33199843Free PMC Article
A systematic review of the oral and craniofacial manifestations of cri du chat syndrome.
Corcuera-Flores JR, Casttellanos-Cosano L, Torres-Lagares D, Serrera-Figallo MÁ, Rodríguez-Caballero Á, Machuca-Portillo G
Clin Anat 2016 Jul;29(5):555-60. Epub 2015 Dec 21 doi: 10.1002/ca.22654. PMID: 26457586
Systematic review and meta-analysis of isolated posterior fossa malformations on prenatal imaging (part 2): neurodevelopmental outcome.
D'Antonio F, Khalil A, Garel C, Pilu G, Rizzo G, Lerman-Sagie T, Bhide A, Thilaganathan B, Manzoli L, Papageorghiou AT
Ultrasound Obstet Gynecol 2016 Jul;48(1):28-37. doi: 10.1002/uog.15755. PMID: 26394557

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...