U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Abnormal paranasal sinus morphology

MedGen UID:
871377
•Concept ID:
C4025873
•
Anatomical Abnormality
Synonyms: Abnormality of the paranasal sinuses; Abnormality of the sinuses; Abnormality of the sinuses of the head
 
HPO: HP:0000245

Definition

Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses. [from HPO]

Conditions with this feature

Aplasia cutis congenita-intestinal lymphangiectasia syndrome
MedGen UID:
349241
•Concept ID:
C1859753
•
Disease or Syndrome
An extremely rare association syndrome, described in only two brothers to date (one of which died at 2 months of age), characterized by aplasia cutis congenita of the vertex and generalized edema (as well as hypoproteinemia and lymphopenia) due to intestinal lymphangiectasia. There have been no further descriptions in the literature since 1985.
See: Condition Record
Aplasia cutis congenita-intestinal lymphangiectasia syndrome

Professional guidelines

PubMed

Nasal polyposis: an overview of differential diagnosis and treatment.
Cingi C, Demirbas D, Ural A
Recent Pat Inflamm Allergy Drug Discov 2011 Sep;5(3):241-52. doi: 10.2174/187221311797264900. PMID: 21834752
Allergic fungal sinusitis: pathophysiology, diagnosis and management.
Schubert MS
Med Mycol 2009;47 Suppl 1:S324-30. Epub 2009 Mar 27 doi: 10.1080/13693780802314809. PMID: 19330659
The pathophysiology and treatment of sinusitis.
Incaudo G, Gershwin ME, Nagy SM
Allergol Immunopathol (Madr) 1986 Sep-Oct;14(5):423-34. PMID: 3541552

Recent clinical studies

Etiology

Sternoclavicular sinus: Case series and literature review of a rare head and neck lesion.
Luu K, Valenzuela D, Chadha NK, Moxham P
Int J Pediatr Otorhinolaryngol 2019 Oct;125:175-181. Epub 2019 Jul 15 doi: 10.1016/j.ijporl.2019.07.016. PMID: 31326735
Anatomic variations associated with antrochoanal polyps.
Gursoy M, Erdogan N, Cetinoglu YK, Dag F, Eren E, Uluc ME
Niger J Clin Pract 2019 May;22(5):603-608. doi: 10.4103/njcp.njcp_419_18. PMID: 31089013
Maxillary sinus aplasia.
Chrcanovic BR, Freire-Maia B
Oral Maxillofac Surg 2010 Sep;14(3):187-91. doi: 10.1007/s10006-009-0200-6. PMID: 20091417
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Phaeohyphomycosis.
Kumar KK, Hallikeri K
Indian J Pathol Microbiol 2008 Oct-Dec;51(4):556-8. doi: 10.4103/0377-4929.43761. PMID: 19008596

Diagnosis

Rhinogenic and sinus headache - Literature review.
Bernichi JV, Rizzo VL, Villa JF, Santos RF, Caparroz FA
Am J Otolaryngol 2021 Nov-Dec;42(6):103113. Epub 2021 Jun 17 doi: 10.1016/j.amjoto.2021.103113. PMID: 34175774
Primary ciliary dyskinesia in adults.
Honoré I, Burgel PR
Rev Mal Respir 2016 Feb;33(2):165-89. Epub 2015 Dec 1 doi: 10.1016/j.rmr.2015.10.743. PMID: 26654126
What do we know about rhinogenic headache? The otolaryngologist’s challenge.
Mehle ME
Otolaryngol Clin North Am 2014 Apr;47(2):255-64. Epub 2014 Jan 10 doi: 10.1016/j.otc.2013.10.006. PMID: 24680492
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Phaeohyphomycosis.
Kumar KK, Hallikeri K
Indian J Pathol Microbiol 2008 Oct-Dec;51(4):556-8. doi: 10.4103/0377-4929.43761. PMID: 19008596

Therapy

Sphenoid sinuses: pneumatisation and anatomical variants-what the radiologist needs to know and report to avoid intraoperative complications.
Cellina M, Gibelli D, Floridi C, Toluian T, Valenti Pittino C, Martinenghi C, Oliva G
Surg Radiol Anat 2020 Sep;42(9):1013-1024. Epub 2020 May 11 doi: 10.1007/s00276-020-02490-y. PMID: 32394118
Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population.
Takeno S, Hirakawa K, Ishino T
Allergol Int 2010 Sep;59(3):247-256. Epub 2010 Jun 25 doi: 10.2332/allergolint.10-RAI-0202. PMID: 20567131
Allergic fungal sinusitis: pathophysiology, diagnosis and management.
Schubert MS
Med Mycol 2009;47 Suppl 1:S324-30. Epub 2009 Mar 27 doi: 10.1080/13693780802314809. PMID: 19330659
Nitric oxide in health and disease from the point of view of the otorhinolaryngologist.
Selimoglu E
Curr Pharm Des 2005;11(23):3051-60. doi: 10.2174/1381612054865037. PMID: 16178763
The pathophysiology and treatment of sinusitis.
Incaudo G, Gershwin ME, Nagy SM
Allergol Immunopathol (Madr) 1986 Sep-Oct;14(5):423-34. PMID: 3541552

Prognosis

Primary ciliary dyskinesia in adults.
Honoré I, Burgel PR
Rev Mal Respir 2016 Feb;33(2):165-89. Epub 2015 Dec 1 doi: 10.1016/j.rmr.2015.10.743. PMID: 26654126
Maxillary sinus aplasia.
Chrcanovic BR, Freire-Maia B
Oral Maxillofac Surg 2010 Sep;14(3):187-91. doi: 10.1007/s10006-009-0200-6. PMID: 20091417
The Arrhinias.
Tessier P, Ciminello FS, Wolfe SA
Scand J Plast Reconstr Surg Hand Surg 2009;43(4):177-96. doi: 10.1080/02844310802517259. PMID: 19401938
Allergic fungal sinusitis: pathophysiology, diagnosis and management.
Schubert MS
Med Mycol 2009;47 Suppl 1:S324-30. Epub 2009 Mar 27 doi: 10.1080/13693780802314809. PMID: 19330659
Maxillary sinus hypoplasia.
Erdem T, Aktas D, Erdem G, Miman MC, Ozturan O
Rhinology 2002 Sep;40(3):150-3. PMID: 12357716

Clinical prediction guides

Isolated Sphenoid Sinus Disease in Children.
Kotowski M, Szydlowski J
Int J Environ Res Public Health 2023 Jan 2;20(1) doi: 10.3390/ijerph20010847. PMID: 36613169Free PMC Article
Variations in Paranasal Sinus Anatomy in Children With Apert Syndrome: A Radiological Analysis.
Turgut NF, Hogg ES, De S, Sharma SD, Avula S
J Craniofac Surg 2022 Mar-Apr 01;33(2):707-709. doi: 10.1097/SCS.0000000000008248. PMID: 35385231
Immunological Features of Paranasal Sinus Mucosa in Patients with Graves' Orbitopathy.
Lu Y, Wu Y, Huang Y, Fang S, Li Y, Sun J, Zhou H
Front Endocrinol (Lausanne) 2020;11:621321. Epub 2021 Feb 10 doi: 10.3389/fendo.2020.621321. PMID: 33643223Free PMC Article
Maxillary sinus septa: a systematic review.
Maestre-Ferrín L, Galán-Gil S, Rubio-Serrano M, Peñarrocha-Diago M, Peñarrocha-Oltra D
Med Oral Patol Oral Cir Bucal 2010 Mar 1;15(2):e383-6. doi: 10.4317/medoral.15.e383. PMID: 19767706
Orbital syndromes.
Bhatti MT
Semin Neurol 2007 Jul;27(3):269-87. doi: 10.1055/s-2007-979685. PMID: 17577868

Recent systematic reviews

Anatomical variations and abnormalities of the maxillary region and clinical implications: A systematic review and metaanalysis.
Valenzuela-Fuenzalida JJ, Baez-Flores B, Sepúlveda RÁ, Medina CM, Pérez R, López E, Sanchis J, Orellana Donoso M, Silva JL, Rodriguez MC, Iwanaga J
Medicine (Baltimore) 2023 Sep 22;102(38):e34510. doi: 10.1097/MD.0000000000034510. PMID: 37747000Free PMC Article
A Systematic Review of Imaging Studies in Olfactory Dysfunction Secondary to COVID-19.
Keshavarz P, Haseli S, Yazdanpanah F, Bagheri F, Raygani N, Karimi-Galougahi M
Acad Radiol 2021 Nov;28(11):1530-1540. Epub 2021 Aug 30 doi: 10.1016/j.acra.2021.08.010. PMID: 34548231Free PMC Article
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature.
Seltzer J, Lucas J, Commins D, Lerner O, Lerner A, Carmichael JD, Zada G
Neurosurg Focus 2015 Feb;38(2):E10. doi: 10.3171/2014.10.FOCUS14685. PMID: 25639312
Maxillary sinus septa: a systematic review.
Maestre-Ferrín L, Galán-Gil S, Rubio-Serrano M, Peñarrocha-Diago M, Peñarrocha-Oltra D
Med Oral Patol Oral Cir Bucal 2010 Mar 1;15(2):e383-6. doi: 10.4317/medoral.15.e383. PMID: 19767706
Do chronic changes in nasal airflow have any physiological or pathological effect on the nose and paranasal sinuses? A systematic review.
Boyce J, Eccles R
Clin Otolaryngol 2006 Feb;31(1):15-9. doi: 10.1111/j.1749-4486.2006.01125.x. PMID: 16441795

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...