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Partial hydatidiform mole

MedGen UID:
87258
•Concept ID:
C0334529
•
Neoplastic Process
Synonyms: Hydatidiform Mole, Partial; Hydatidiform Moles, Partial; Mole, Partial Hydatidiform; Moles, Partial Hydatidiform; Partial Hydatidiform Mole; Partial Hydatidiform Moles
SNOMED CT: Partial mole (51793002); Incomplete hydatidiform mole (237250000); Partial hydatidiform mole (237250000); PHM - Partial hydatidiform mole (237250000); Partial hydatidiform mole (51793002)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0016786
Orphanet: ORPHA254693

Definition

A form of hydatiform mole characterized by abnormal hyperplastic trophoblasts and hydropic villi due to fertilization of a normal ovocyte by two spermatozoa or one abnormal spermatozoon (allowing for some fetal development), and that manifests with vaginal bleeding accompanied by nausea and frequent vomiting, hyperemesis gravidarum, hyperthyroidism and risk of spontaneous miscarriage. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPartial hydatidiform mole
Follow this link to review classifications for Partial hydatidiform mole in Orphanet.

Professional guidelines

PubMed

Partial Hydatidiform Mole with a Coexistent Twin Pregnancy: A Successful Outcome with Expectant Management.
Banerjee A, Oniah M, Cohn MR, Marsden L
J Obstet Gynaecol Can 2023 Apr;45(4):243-244. Epub 2021 Jun 29 doi: 10.1016/j.jogc.2021.01.017. PMID: 35589517
Placental mesenchymal dysplasia - morphology and differential diagnosis.
Daumová M, Hadravská Š, Peteříková AS, Hasch M, Martínek P
Cesk Patol 2021 Winter;57(4):203-207. PMID: 35042352
Prenatal diagnosis and management of twin pregnancies complicated by a co-existing molar pregnancy.
Wee L, Jauniaux E
Prenat Diagn 2005 Sep;25(9):772-6. doi: 10.1002/pd.1272. PMID: 16170836

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

Recent clinical studies

Etiology

Obstetrical and oncological outcomes of twin pregnancies with hydatidiform mole and coexisting fetus.
Liang H, Pan NP, Wang YF, Ye CS, Yan ZQ, Wu RJ
Taiwan J Obstet Gynecol 2022 May;61(3):453-458. doi: 10.1016/j.tjog.2022.03.010. PMID: 35595437
The immune microenvironment of the hydatidiform mole.
Dridi M, Papoudou-Bai A, Kanavaros P, Perard M, Clemenson A, Chauleur C, Peoc'h M, Karpathiou G
Hum Pathol 2022 Feb;120:35-45. Epub 2021 Dec 17 doi: 10.1016/j.humpath.2021.12.002. PMID: 34929228
Triploid pregnancy-Clinical implications.
Massalska D, Bijok J, Kucińska-Chahwan A, Zimowski JG, Ozdarska K, Panek G, Roszkowski T
Clin Genet 2021 Oct;100(4):368-375. Epub 2021 Jun 1 doi: 10.1111/cge.14003. PMID: 34031868
Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.
Ronnett BM
Arch Pathol Lab Med 2018 Dec;142(12):1485-1502. doi: 10.5858/arpa.2018-0226-RA. PMID: 30500280
Histological comparison of partial hydatidiform mole and trisomy gestation specimens.
Wilson Y, Bharat C, Crook ML, Kee AR, Peverall J, Ruba S, Stewart CJ
Pathology 2016 Oct;48(6):550-4. Epub 2016 Aug 26 doi: 10.1016/j.pathol.2016.06.006. PMID: 27575970

Diagnosis

Triploid pregnancy-Clinical implications.
Massalska D, Bijok J, Kucińska-Chahwan A, Zimowski JG, Ozdarska K, Panek G, Roszkowski T
Clin Genet 2021 Oct;100(4):368-375. Epub 2021 Jun 1 doi: 10.1111/cge.14003. PMID: 34031868
Genetics of gestational trophoblastic disease.
Fisher RA, Maher GJ
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:29-41. Epub 2021 Feb 2 doi: 10.1016/j.bpobgyn.2021.01.004. PMID: 33685819
Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.
Ronnett BM
Arch Pathol Lab Med 2018 Dec;142(12):1485-1502. doi: 10.5858/arpa.2018-0226-RA. PMID: 30500280
Gestational trophoblastic disease.
Seckl MJ, Sebire NJ, Berkowitz RS
Lancet 2010 Aug 28;376(9742):717-29. Epub 2010 Jul 29 doi: 10.1016/S0140-6736(10)60280-2. PMID: 20673583
Intraligamentary pregnancy.
Cordero DR, Adra A, Yasin S, O'Sullivan MJ
Obstet Gynecol Surv 1994 Mar;49(3):206-9. doi: 10.1097/00006254-199403000-00026. PMID: 8164915

Therapy

Partial hydatidiform mole and coexisting fetus after frozen embryo transplantation: a case report.
Li J, Sun X
JBRA Assist Reprod 2024 Feb 26;28(1):200-202. doi: 10.5935/1518-0557.20230069. PMID: 38224576Free PMC Article
Experience of women on the Irish National Gestational Trophoblastic Disease Registry.
Joyce CM, Coulter J, Kenneally C, McCarthy TV, O'Donoghue K
Eur J Obstet Gynecol Reprod Biol 2022 May;272:206-212. Epub 2022 Mar 28 doi: 10.1016/j.ejogrb.2022.03.039. PMID: 35367922
Partial hydatidiform mole in a phenylketonuria patient treated with sapropterin dihydrochloride.
Yildiz Y, Dursun A, Tokatli A, Coskun T, Sivri S
Gynecol Endocrinol 2017 Jan;33(1):19-20. Epub 2016 Nov 29 doi: 10.1080/09513590.2016.1247796. PMID: 27898272
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Coexisting true hermaphroditism and partial hydatidiform mole developing metastatic gestational trophoblastic tumors. A case report.
Shiina H, Oka K, Okane M, Tanno W, Kawasaki T, Nakayama M
Virchows Arch 2002 Nov;441(5):514-8. Epub 2002 Aug 22 doi: 10.1007/s00428-002-0681-2. PMID: 12447683

Prognosis

Changes in diagnostic sensitivity, incidence and presentation of complete and partial hydatidiform mole over the years.
Aiob A, Naskovica K, Amdur Zilberfarb I, Sharon A, Bornstein J, Lowenstein L
Eur J Obstet Gynecol Reprod Biol 2022 Jul;274:136-141. Epub 2022 May 25 doi: 10.1016/j.ejogrb.2022.05.026. PMID: 35640442
Triploid pregnancy-Clinical implications.
Massalska D, Bijok J, Kucińska-Chahwan A, Zimowski JG, Ozdarska K, Panek G, Roszkowski T
Clin Genet 2021 Oct;100(4):368-375. Epub 2021 Jun 1 doi: 10.1111/cge.14003. PMID: 34031868
Reproductive outcomes after hydatiform mole and gestational trophoblastic neoplasia.
Gadducci A, Lanfredini N, Cosio S
Gynecol Endocrinol 2015;31(9):673-8. Epub 2015 Aug 18 doi: 10.3109/09513590.2015.1054803. PMID: 26288335
Current clinical features of complete and partial hydatidiform mole in Sweden.
Joneborg U, Marions L
J Reprod Med 2014 Jan-Feb;59(1-2):51-5. PMID: 24597287
Intraligamentary pregnancy.
Cordero DR, Adra A, Yasin S, O'Sullivan MJ
Obstet Gynecol Surv 1994 Mar;49(3):206-9. doi: 10.1097/00006254-199403000-00026. PMID: 8164915

Clinical prediction guides

The immune microenvironment of the hydatidiform mole.
Dridi M, Papoudou-Bai A, Kanavaros P, Perard M, Clemenson A, Chauleur C, Peoc'h M, Karpathiou G
Hum Pathol 2022 Feb;120:35-45. Epub 2021 Dec 17 doi: 10.1016/j.humpath.2021.12.002. PMID: 34929228
Triploid pregnancy-Clinical implications.
Massalska D, Bijok J, Kucińska-Chahwan A, Zimowski JG, Ozdarska K, Panek G, Roszkowski T
Clin Genet 2021 Oct;100(4):368-375. Epub 2021 Jun 1 doi: 10.1111/cge.14003. PMID: 34031868
Ultrasound diagnosis of complete and partial hydatidiform moles in early pregnancy failure: An inter-observer study.
Jauniaux E, Memtsa M, Johns J, Ross JA, Sebire NJ, Jurkovic D
Placenta 2020 Aug;97:65-67. Epub 2020 Jun 17 doi: 10.1016/j.placenta.2020.06.013. PMID: 32792066
Hydatidiform Moles: Ancillary Techniques to Refine Diagnosis.
Ronnett BM
Arch Pathol Lab Med 2018 Dec;142(12):1485-1502. doi: 10.5858/arpa.2018-0226-RA. PMID: 30500280
Current clinical features of complete and partial hydatidiform mole in Sweden.
Joneborg U, Marions L
J Reprod Med 2014 Jan-Feb;59(1-2):51-5. PMID: 24597287

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

    Reviews

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