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Hemosiderotic Fibrolipomatous Tumor

MedGen UID:
881863
Concept ID:
C4053521
Neoplastic Process
Synonym: Hemosiderotic Fibrohistiocytic Lipomatous Lesion

Definition

A non-encapsulated, slow-growing, locally aggressive subcutaneous tumor characterized by the presence of adipocytes, hemosiderin-laden spindle cells, hemosiderin-laden macrophages, osteoclast-like giant cells, and scattered chronic inflammatory cells. It usually arises from the dorsum of the foot, ankle, dorsum of the hand, thigh, calf, or cheek. It may recur if it is not completely excised but does not metastasize. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHemosiderotic Fibrolipomatous Tumor

Recent clinical studies

Etiology

Buehler D, Weisman P
Clin Lab Med 2017 Sep;37(3):647-671. doi: 10.1016/j.cll.2017.06.005. PMID: 28802505
Kao YC, Ranucci V, Zhang L, Sung YS, Athanasian EA, Swanson D, Dickson BC, Antonescu CR
Am J Surg Pathol 2017 Nov;41(11):1456-1465. doi: 10.1097/PAS.0000000000000899. PMID: 28692601Free PMC Article
Carter JM, Sukov WR, Montgomery E, Goldblum JR, Billings SD, Fritchie KJ, Folpe AL
Am J Surg Pathol 2014 Sep;38(9):1182-992. doi: 10.1097/PAS.0000000000000212. PMID: 24705316
Antonescu CR, Zhang L, Nielsen GP, Rosenberg AE, Dal Cin P, Fletcher CD
Genes Chromosomes Cancer 2011 Oct;50(10):757-64. Epub 2011 Jun 29 doi: 10.1002/gcc.20897. PMID: 21717526Free PMC Article

Diagnosis

Pang CY, Wong E, Liao JW, Chan JKC, Cheuk W
Int J Surg Pathol 2021 Feb;29(1):64-68. Epub 2020 Jun 3 doi: 10.1177/1066896920930799. PMID: 32493078
Lucas DR
Arch Pathol Lab Med 2017 Nov;141(11):1503-1507. doi: 10.5858/arpa.2017-0219-RA. PMID: 29072951
Buehler D, Weisman P
Clin Lab Med 2017 Sep;37(3):647-671. doi: 10.1016/j.cll.2017.06.005. PMID: 28802505
Boland JM, Folpe AL
Adv Anat Pathol 2017 Sep;24(5):268-277. doi: 10.1097/PAP.0000000000000151. PMID: 28375867
O'Driscoll D, Athanasian E, Hameed M, Hwang S
Skeletal Radiol 2015 May;44(5):641-8. Epub 2014 Dec 21 doi: 10.1007/s00256-014-2078-0. PMID: 25527465

Prognosis

Agaimy A, Meidenbauer N, Sukov WR, Stoehr R, Vieth M, Roemer F, Grützmann R, Folpe AL
Virchows Arch 2022 May;480(5):1115-1120. Epub 2021 Aug 14 doi: 10.1007/s00428-021-03167-6. PMID: 34389899Free PMC Article
Lucas DR
Arch Pathol Lab Med 2017 Nov;141(11):1503-1507. doi: 10.5858/arpa.2017-0219-RA. PMID: 29072951
Zreik RT, Carter JM, Sukov WR, Ahrens WA, Fritchie KJ, Montgomery EA, Weiss SW, Folpe AL
Hum Pathol 2016 Jul;53:14-24. Epub 2016 Mar 2 doi: 10.1016/j.humpath.2016.02.005. PMID: 26980036
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856
Antonescu CR, Zhang L, Nielsen GP, Rosenberg AE, Dal Cin P, Fletcher CD
Genes Chromosomes Cancer 2011 Oct;50(10):757-64. Epub 2011 Jun 29 doi: 10.1002/gcc.20897. PMID: 21717526Free PMC Article

Clinical prediction guides

Kao YC, Ranucci V, Zhang L, Sung YS, Athanasian EA, Swanson D, Dickson BC, Antonescu CR
Am J Surg Pathol 2017 Nov;41(11):1456-1465. doi: 10.1097/PAS.0000000000000899. PMID: 28692601Free PMC Article
Zreik RT, Carter JM, Sukov WR, Ahrens WA, Fritchie KJ, Montgomery EA, Weiss SW, Folpe AL
Hum Pathol 2016 Jul;53:14-24. Epub 2016 Mar 2 doi: 10.1016/j.humpath.2016.02.005. PMID: 26980036
Carter JM, Sukov WR, Montgomery E, Goldblum JR, Billings SD, Fritchie KJ, Folpe AL
Am J Surg Pathol 2014 Sep;38(9):1182-992. doi: 10.1097/PAS.0000000000000212. PMID: 24705316
Fletcher CD
Mod Pathol 2014 Jan;27 Suppl 1:S98-112. doi: 10.1038/modpathol.2013.172. PMID: 24384856

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