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Resistant ovary syndrome

MedGen UID:: 88557
•Concept ID:: C0086367
•: Disease or Syndrome

Synonyms:	Gonadotropin Resistant Ovary Syndrome; Gonadotropin-Resistant Ovary Syndrome; Resistant Ovary Syndrome
SNOMED CT:	Resistant ovary syndrome (80956002)

Definition

Ovarian dysfunction due to a defect at the receptor or post receptor level, or due to the presence of antibodies against gonadotropin receptors, resulting in deficient gonadotropin signaling that causes elevated concentrations of follicle stimulating hormone and/or luteinizing hormone. A distinguishing feature is the presence of normal numbers of ova. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVResistant ovary syndrome

Disorder of the genitourinary system
- Diseases, Genital
  - Disorder of female genital system
    - Adnexal Diseases
      - Disorder of ovary
        Ovarian Non-Neoplastic Disorder
        Resistant ovary syndrome

Professional guidelines

PubMed

The live birth in a woman with resistant ovary syndrome after in vitro oocyte maturation and preimplantation genetic testing for aneuploidy.

Kornilov NV, Pavlova MN, Yakovlev PP
J Assist Reprod Genet 2021 Jun;38(6):1303-1309. Epub 2021 Jan 26 doi: 10.1007/s10815-021-02085-5. PMID: 33495936 Free PMC Article

Could transvaginal, ultrasound-guided ovarian interstitial laser treatment replace laparoscopic ovarian drilling in women with polycystic ovary syndrome resistant to clomiphene citrate?

Api M
Fertil Steril 2009 Dec;92(6):2039-40. Epub 2009 Jul 15 doi: 10.1016/j.fertnstert.2009.06.024. PMID: 19608164

Luteinizing hormone releasing hormone analogue in treatment of hypergonadotrophic amenorrhoea.

Menon V, Edwards RL, Lynch SS, Butt WR
Br J Obstet Gynaecol 1983 Jun;90(6):539-42. doi: 10.1111/j.1471-0528.1983.tb08964.x. PMID: 6407517

See all (3)

Recent clinical studies

Etiology

Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome.

Zhang F, Zhang H, Du H, Li X, Jin H, Li G
BMC Pregnancy Childbirth 2023 Mar 15;23(1):178. doi: 10.1186/s12884-023-05477-w. PMID: 36922772 Free PMC Article

Diagnostic role of inhibin B in resistant ovary syndrome associated with secondary amenorrhea.

Arici A, Matalliotakis IM, Koumantakis GE, Goumenou AG, Neonaki MA, Koumantakis EE
Fertil Steril 2002 Dec;78(6):1324-6. doi: 10.1016/s0015-0282(02)04239-5. PMID: 12477534

Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome.

Conway GS, Conway E, Walker C, Hoppner W, Gromoll J, Simoni M
Clin Endocrinol (Oxf) 1999 Jul;51(1):97-9. doi: 10.1046/j.1365-2265.1999.00745.x. PMID: 10468971

Noninvasive diagnosis of resistant ovary syndrome by ultrasonography.

Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331

Receptors, antibodies, and disease.

Blecher M
Clin Chem 1984 Jul;30(7):1137-56. PMID: 6329552

See all (9)

Diagnosis

Application value of Early-Follicular Phase Long-Acting Gonadotropin-Releasing Hormone Agonist Long Protocol in patients with resistant ovary syndrome.

Zhang F, Zhang H, Du H, Li X, Jin H, Li G
BMC Pregnancy Childbirth 2023 Mar 15;23(1):178. doi: 10.1186/s12884-023-05477-w. PMID: 36922772 Free PMC Article

Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report.

Mu Z, Song J, Yu Y, Sun Z
Medicine (Baltimore) 2020 May;99(20):e20199. doi: 10.1097/MD.0000000000020199. PMID: 32443342 Free PMC Article

Effective ovarian stimulation in a patient with resistant ovary syndrome and antigonadotrophin antibodies.

Rogenhofer N, Pavlik R, Jeschke U, Wypior G, Ochsenkühn R, Thaler CJ
Am J Reprod Immunol 2015 Feb;73(2):185-91. Epub 2014 Aug 14 doi: 10.1111/aji.12306. PMID: 25123925

Noninvasive diagnosis of resistant ovary syndrome by ultrasonography.

Mehta AE, Matwijiw I, Lyons EA, Faiman C
Fertil Steril 1992 Jan;57(1):56-61. PMID: 1730331

The resistant ovary syndrome.

Dewhurst CJ, de Koos EB, Ferreira HP
Br J Obstet Gynaecol 1975 Apr;82(4):341-5. doi: 10.1111/j.1471-0528.1975.tb00646.x. PMID: 1125157

See all (27)

Therapy

Resistant ovary syndrome: Two case reports and a literature review of effective controlled ovarian stimulation in IVF.

Zhao S, Zheng W, Gu X, Liang G, Long G
Medicine (Baltimore) 2024 May 3;103(18):e37886. doi: 10.1097/MD.0000000000037886. PMID: 38701292 Free PMC Article

Case report: Birth achieved after effective ovarian stimulation combined with dexamethasone in a patient with resistant ovary syndrome.

Li H, Chang T, Mu H, Xiang W
J Ovarian Res 2022 Apr 7;15(1):42. doi: 10.1186/s13048-022-00976-4. PMID: 35392972 Free PMC Article

Hippo signaling disruption and ovarian follicle activation in infertile patients.

Hsueh AJW, Kawamura K
Fertil Steril 2020 Sep;114(3):458-464. Epub 2020 Aug 8 doi: 10.1016/j.fertnstert.2020.07.031. PMID: 32782158

Successful live birth in a woman with resistant ovary syndrome treated with letrozole and HMG: A case report.

Mu Z, Song J, Yu Y, Sun Z
Medicine (Baltimore) 2020 May;99(20):e20199. doi: 10.1097/MD.0000000000020199. PMID: 32443342 Free PMC Article

The gonadotrophin resistant ovary syndrome: a curable disease?

Evers JL, Rolland R
Clin Endocrinol (Oxf) 1981 Jan;14(1):99-103. doi: 10.1111/j.1365-2265.1981.tb00370.x. PMID: 6784984

See all (20)

Prognosis

Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome.

Chen X, Chen L, Wang Y, Shu C, Zhou Y, Wu R, Jin B, Yang L, Sun J, Qi M, Shu J
Front Endocrinol (Lausanne) 2022;13:1013894. Epub 2023 Jan 10 doi: 10.3389/fendo.2022.1013894. PMID: 36704038 Free PMC Article

Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases.

Le HL, Ho VNA, Le TTN, Tran VTT, Ma MPQ, Le AH, Nguyen LK, Ho TM, Vuong LN
J Assist Reprod Genet 2021 Dec;38(12):3243-3249. Epub 2021 Nov 30 doi: 10.1007/s10815-021-02355-2. PMID: 34846627 Free PMC Article

Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome.

He WB, Du J, Yang XW, Li W, Tang WL, Dai C, Chen YZ, Zhang YX, Lu GX, Lin G, Gong F, Tan YQ
Reprod Biomed Online 2019 Mar;38(3):397-406. Epub 2018 Dec 8 doi: 10.1016/j.rbmo.2018.11.011. PMID: 30691934

Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?

Chiauzzi VA, Bussmann L, Calvo JC, Sundblad V, Charreau EH
Clin Endocrinol (Oxf) 2004 Jul;61(1):46-54. doi: 10.1111/j.1365-2265.2004.02054.x. PMID: 15212644

The resistant ovary syndrome in a patient with galactosemia: a clue to the natural history of ovarian failure.

Twigg S, Wallman L, McElduff A
J Clin Endocrinol Metab 1996 Apr;81(4):1329-31. doi: 10.1210/jcem.81.4.8636327. PMID: 8636327

See all (6)

Clinical prediction guides

Identification and characterization of novel compound heterozygous variants in FSHR causing primary ovarian insufficiency with resistant ovary syndrome.

Live birth after in vitro maturation in women with gonadotropin resistance ovary syndrome: report of two cases.

Novel inactivating mutations in the FSH receptor cause premature ovarian insufficiency with resistant ovary syndrome.

Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?

Chiauzzi VA, Bussmann L, Calvo JC, Sundblad V, Charreau EH
Clin Endocrinol (Oxf) 2004 Jul;61(1):46-54. doi: 10.1111/j.1365-2265.2004.02054.x. PMID: 15212644

Hormonal and ultrastructural observations in a case of resistant ovary syndrome.

Starup J, Pedersen H
Acta Endocrinol (Copenh) 1978 Dec;89(4):744-52. doi: 10.1530/acta.0.0890744. PMID: 716779

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