Testicular non-seminomatous germ cell tumor

MedGen UID:: 890627
•Concept ID:: C2057625
•: Neoplastic Process

Synonyms:	Non-dysgerminomatous germ cell tumor of testis; non-dysgerminomatous germ cell tumor of testis; non-dysgerminomatous germ cell tumour of testis; Non-seminomatous germ cell neoplasm of testis; non-seminomatous germ cell tumor of testis; Non-seminomatous germ cell tumor of testis; non-seminomatous germ cell tumour of testis; Nonseminomatous germ cell tumor of testis; Testicular Germ Cell Tumor Non-Seminomatous; testicular germ cell tumor non-seminomatous; testicular germ cell tumour non-seminomatous; Testicular non seminomatous germ cell tumor; testicular non seminomatous germ cell tumor; testicular non seminomatous germ cell tumour; Testicular non-dysgerminomatous germ cell tumor; testicular non-dysgerminomatous germ cell tumor; testicular non-dysgerminomatous germ cell tumour; Testicular Non-Seminomatous Germ Cell Tumor; testicular non-seminomatous germ cell tumor
SNOMED CT:	Non-seminomatous germ cell neoplasm of testis (107691000119101); Nonseminomatous germ cell tumor of testis (107691000119101)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0006447
Orphanet:	ORPHA363494

Definition

A form of testicular germ cell tumor occurring in the third decade of life with a usually painless unilateral mass in the scrotum or, in some cases, with gynaecomastia and/or back and flack pain. The clinical course is more aggressive than testicular seminomatous germ cell tumors with rapid involvement of blood vessels and a poorer prognosis. Histologically, the tumour can be either undifferentiated (embryonal carcinoma), differentiated (teratoma, yolk sac tumor, choriocarcinoma), or can consist of a mixture of seminomatous and nonseminomatous components. [from ORDO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVTesticular non-seminomatous germ cell tumor

Disease
- Disorder by Site
  - Disorder of the genitourinary system
    - Neoplasm of the genitourinary tract
      - Malignant tumor of testis
        Germ cell tumor of testis
        Testicular non-seminomatous germ cell tumor

Professional guidelines

PubMed

Peri-treatment adverse events of primary mediastinal non-seminomatous germ cell tumors.

Chen RL, Liu CC, Ip PP, Fang LH, Shih LS, Chen LY
Pediatr Blood Cancer 2022 Aug;69(8):e29781. Epub 2022 May 20 doi: 10.1002/pbc.29781. PMID: 35593015

Management of Residual Mass in Germ Cell Tumors After Chemotherapy.

Albany C, Kesler K, Cary C
Curr Oncol Rep 2019 Jan 21;21(1):5. doi: 10.1007/s11912-019-0758-6. PMID: 30666469

Management of clinical stage I nonseminomatous germ cell tumors.

Isharwal S, Risk MC
Expert Rev Anticancer Ther 2014 Sep;14(9):1021-32. Epub 2014 Jun 14 doi: 10.1586/14737140.2014.928593. PMID: 24931909

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Recent clinical studies

Etiology

Identification of a subgroup with worse prognosis among patients with poor-risk testicular germ cell tumor.

Kojima T, Kawai K, Tsuchiya K, Abe T, Shinohara N, Tanaka T, Masumori N, Yamada S, Arai Y, Narita S, Tsuchiya N, Habuchi T, Nishiyama H
Int J Urol 2015 Oct;22(10):923-7. Epub 2015 Jun 18 doi: 10.1111/iju.12844. PMID: 26094715

See all (1)