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Corticotropin-releasing hormone receptor defect

MedGen UID:
892780
•Concept ID:
C4023210
•
Finding
Synonyms: Corticotropin-releasing hormone receptor (CRHR) resistance; CRHR defect
 
HPO: HP:0011738

Definition

Adrenal insufficiency secondary to a defect in the corticotropin-releasing hormone receptor. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorticotropin-releasing hormone receptor defect

Professional guidelines

PubMed

Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment.
Rasmusson AM, Pineles SL
Curr Psychiatry Rep 2018 Jul 17;20(7):52. doi: 10.1007/s11920-018-0908-9. PMID: 30019147
CRH-sub-1 receptor antagonists for the treatment of depression and anxiety.
Ising M, Holsboer F
Exp Clin Psychopharmacol 2007 Dec;15(6):519-28. doi: 10.1037/1064-1297.15.6.519. PMID: 18179304
Pharmacologic management of Cushing syndrome : new targets for therapy.
Sonino N, Boscaro M, Fallo F
Treat Endocrinol 2005;4(2):87-94. doi: 10.2165/00024677-200504020-00003. PMID: 15783246

Recent clinical studies

Etiology

Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment.
Rasmusson AM, Pineles SL
Curr Psychiatry Rep 2018 Jul 17;20(7):52. doi: 10.1007/s11920-018-0908-9. PMID: 30019147
Corticotropin-releasing factor (CRF) system localization in human fetal heart.
Chouridou E, Lambropoulou M, Koureta M, Zarouchlioti C, Balgouranidou I, Nena E, Papadopoulos N, Chatzaki E
Hormones (Athens) 2016 Jan-Mar;15(1):55-64. doi: 10.14310/horm.2002.1661. PMID: 27377597
Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy.
Zhou F, He MM, Liu ZF, Zhang L, Gao BX, Wang XD
Placenta 2013 May;34(5):401-6. Epub 2013 Mar 9 doi: 10.1016/j.placenta.2013.02.006. PMID: 23478074
Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning.
Bogdan R, Santesso DL, Fagerness J, Perlis RH, Pizzagalli DA
J Neurosci 2011 Sep 14;31(37):13246-54. doi: 10.1523/JNEUROSCI.2661-11.2011. PMID: 21917807Free PMC Article
Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression.
Hatzinger M
World J Biol Psychiatry 2000 Apr;1(2):105-11. doi: 10.3109/15622970009150573. PMID: 12607206

Diagnosis

The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity.
Abbas A, Hammad AS, Al-Shafai M
Mutat Res Rev Mutat Res 2024 Jan-Jun;793:108487. Epub 2023 Dec 14 doi: 10.1016/j.mrrev.2023.108487. PMID: 38103632
Corticotropin-releasing factor (CRF) system localization in human fetal heart.
Chouridou E, Lambropoulou M, Koureta M, Zarouchlioti C, Balgouranidou I, Nena E, Papadopoulos N, Chatzaki E
Hormones (Athens) 2016 Jan-Mar;15(1):55-64. doi: 10.14310/horm.2002.1661. PMID: 27377597
Nonpeptide corticotropin-releasing hormone receptor type 1 antagonists and their applications in psychosomatic disorders.
Contoreggi C, Rice KC, Chrousos G
Neuroendocrinology 2004;80(2):111-23. Epub 2004 Oct 27 doi: 10.1159/000081785. PMID: 15523186
Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.
Plotsky PM, Owens MJ, Nemeroff CB
Psychiatr Clin North Am 1998 Jun;21(2):293-307. doi: 10.1016/s0193-953x(05)70006-x. PMID: 9670227
Ectopic ACTH syndrome.
Wajchenberg BL, Mendonça B, Liberman B, Adelaide M, Pereira A, Kirschner MA
J Steroid Biochem Mol Biol 1995 Jun;53(1-6):139-51. doi: 10.1016/0960-0760(95)00044-z. PMID: 7626446

Therapy

The HPA Axis as Target for Depression.
Menke A
Curr Neuropharmacol 2024;22(5):904-915. doi: 10.2174/1570159X21666230811141557. PMID: 37581323Free PMC Article
Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder.
Dunlop BW, Binder EB, Iosifescu D, Mathew SJ, Neylan TC, Pape JC, Carrillo-Roa T, Green C, Kinkead B, Grigoriadis D, Rothbaum BO, Nemeroff CB, Mayberg HS
Biol Psychiatry 2017 Dec 15;82(12):866-874. Epub 2017 Jul 4 doi: 10.1016/j.biopsych.2017.06.024. PMID: 28793974Free PMC Article
Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression.
Kunugi H, Hori H, Adachi N, Numakawa T
Psychiatry Clin Neurosci 2010 Oct;64(5):447-59. doi: 10.1111/j.1440-1819.2010.02135.x. PMID: 20923424
CRH-sub-1 receptor antagonists for the treatment of depression and anxiety.
Ising M, Holsboer F
Exp Clin Psychopharmacol 2007 Dec;15(6):519-28. doi: 10.1037/1064-1297.15.6.519. PMID: 18179304
Vasopressin as a target for antidepressant development: an assessment of the available evidence.
Scott LV, Dinan TG
J Affect Disord 2002 Nov;72(2):113-24. doi: 10.1016/s0165-0327(02)00026-5. PMID: 12200202

Prognosis

Reversible Hypopituitarism Associated with Intravascular Large B-Cell Lymphoma: Case Report of Successful Immunochemotherapy.
Sawada Y, Ishii S, Koga Y, Tomizawa T, Matsui A, Tomaru T, Ozawa A, Shibusawa N, Satoh T, Shimizu H, Hirato J, Yamada M
Tohoku J Exp Med 2016 Mar;238(3):197-203. doi: 10.1620/tjem.238.197. PMID: 26936510
Expression of urocortin and corticotrophin-releasing hormone receptor-2 in patients with intrahepatic cholestasis of pregnancy.
Zhou F, Zhang L, Sun Q, Wang XD
Placenta 2014 Nov;35(11):962-8. Epub 2014 Aug 15 doi: 10.1016/j.placenta.2014.07.019. PMID: 25172671
Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro.
Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Söderholm JD
Gut 2008 Jan;57(1):50-8. Epub 2007 May 24 doi: 10.1136/gut.2006.117549. PMID: 17525093
Stress responsive neurohormones in depression and anxiety.
Ströhle A, Holsboer F
Pharmacopsychiatry 2003 Nov;36 Suppl 3:S207-14. doi: 10.1055/s-2003-45132. PMID: 14677081
Neuropeptides and the hypothalamic-pituitary-adrenocortical (HPA) system: review of recent research strategies in depression.
Hatzinger M
World J Biol Psychiatry 2000 Apr;1(2):105-11. doi: 10.3109/15622970009150573. PMID: 12607206

Clinical prediction guides

Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons.
Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM
Cell Death Dis 2020 Nov 23;11(11):1004. doi: 10.1038/s41419-020-03204-3. PMID: 33230105Free PMC Article
Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder.
Dunlop BW, Binder EB, Iosifescu D, Mathew SJ, Neylan TC, Pape JC, Carrillo-Roa T, Green C, Kinkead B, Grigoriadis D, Rothbaum BO, Nemeroff CB, Mayberg HS
Biol Psychiatry 2017 Dec 15;82(12):866-874. Epub 2017 Jul 4 doi: 10.1016/j.biopsych.2017.06.024. PMID: 28793974Free PMC Article
Expression of corticotrophin-releasing hormone and its receptor in patients with intrahepatic cholestasis of pregnancy.
Zhou F, He MM, Liu ZF, Zhang L, Gao BX, Wang XD
Placenta 2013 May;34(5):401-6. Epub 2013 Mar 9 doi: 10.1016/j.placenta.2013.02.006. PMID: 23478074
Nonpeptide corticotropin-releasing hormone receptor type 1 antagonists and their applications in psychosomatic disorders.
Contoreggi C, Rice KC, Chrousos G
Neuroendocrinology 2004;80(2):111-23. Epub 2004 Oct 27 doi: 10.1159/000081785. PMID: 15523186
Psychoneuroendocrinology of depression. Hypothalamic-pituitary-adrenal axis.
Plotsky PM, Owens MJ, Nemeroff CB
Psychiatr Clin North Am 1998 Jun;21(2):293-307. doi: 10.1016/s0193-953x(05)70006-x. PMID: 9670227

Recent systematic reviews

The HPA axis in bipolar disorder: Systematic review and meta-analysis.
Belvederi Murri M, Prestia D, Mondelli V, Pariante C, Patti S, Olivieri B, Arzani C, Masotti M, Respino M, Antonioli M, Vassallo L, Serafini G, Perna G, Pompili M, Amore M
Psychoneuroendocrinology 2016 Jan;63:327-42. Epub 2015 Oct 21 doi: 10.1016/j.psyneuen.2015.10.014. PMID: 26547798

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