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Malignant giant cell tumor

MedGen UID:
90745
•Concept ID:
C0334229
•
Neoplastic Process
Synonyms: giant cell tumor, malignant; Malignant Giant Cell Neoplasm; malignant giant cell neoplasm; Malignant Giant Cell Tumor; malignant giant cell tumor; Malignant tumor - giant cell type; Malignant tumor, giant cell type; malignant tumor, giant cell type; malignant tumor, giant cell type (morphologic abnormality)
SNOMED CT: Malignant tumor - giant cell type (83950009); Malignant tumor, giant cell type (83950009)
 
Monarch Initiative: MONDO:0002402

Definition

A malignant neoplasm characterized by then presence of atypical giant cells. [from NCI]

Professional guidelines

PubMed

Real-world treatment and survival outcome of malignant giant cell tumor of bone in the pre-denosumab versus post-denosumab era.
Hu X, Sun Z, Huang W, Sun Y, Yan W
Int J Surg 2022 Jun;102:106667. Epub 2022 May 10 doi: 10.1016/j.ijsu.2022.106667. PMID: 35562002
The role of fine needle aspiration biopsy in the diagnosis and management of osteosarcoma.
Kilpatrick SE, Ward WG, Bos GD, Chauvenet AR, Gold SH
Pediatr Pathol Mol Med 2001 May-Jun;20(3):175-87. PMID: 11486348
Cryosurgery and acrylic cementation as surgical adjuncts in the treatment of aggressive (benign) bone tumors. Analysis of 25 patients below the age of 21.
Malawer MM, Dunham W
Clin Orthop Relat Res 1991 Jan;(262):42-57. PMID: 1984931

Recent clinical studies

Etiology

Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy.
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Treatment and outcome of malignant giant cell tumor in the spine.
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Primary malignant giant-cell tumor of bone has high survival rate.
Domovitov SV, Healey JH
Ann Surg Oncol 2010 Mar;17(3):694-701. Epub 2009 Nov 10 doi: 10.1245/s10434-009-0803-z. PMID: 19902306
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis).
Bertoni F, Unni KK, Beabout JW, Sim FH
Am J Surg Pathol 1997 Feb;21(2):153-63. doi: 10.1097/00000478-199702000-00004. PMID: 9042281
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients.
Rock MG, Sim FH, Unni KK, Witrak GA, Frassica FJ, Schray MF, Beabout JW, Dahlin DC
J Bone Joint Surg Am 1986 Sep;68(7):1073-9. PMID: 3745247

Diagnosis

Malignant giant cell tumor of toe: A case report and review of literature.
Hashimoto K, Nishimura S, Ito T, Akagi M
Medicine (Baltimore) 2022 Jun 3;101(22):e29471. doi: 10.1097/MD.0000000000029471. PMID: 35665736Free PMC Article
Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy.
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article
Treatment and outcome of malignant giant cell tumor in the spine.
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Histological and clinical characteristics of malignant giant cell tumor of bone.
Gong L, Liu W, Sun X, Sajdik C, Tian X, Niu X, Huang X
Virchows Arch 2012 Mar;460(3):327-34. Epub 2012 Feb 17 doi: 10.1007/s00428-012-1198-y. PMID: 22350004

Therapy

Metastatic Giant Cell Tumor Causing Small Bowel Intussusception on 18 F-FDG PET/CT.
Walcutt JE, Johnson CM, Ly QP, Downey RT
Clin Nucl Med 2022 Nov 1;47(11):963-964. Epub 2022 Jul 6 doi: 10.1097/RLU.0000000000004287. PMID: 35777978
Efficacy of Pazopanib in the Treatment of Metastatic Malignant Giant Cell Tumor of Soft Tissue: A Case Report.
Iwai T, Oebisu N, Hoshi M, Takada N, Nakamura H
Curr Oncol 2022 Jan 31;29(2):758-765. doi: 10.3390/curroncol29020064. PMID: 35200563Free PMC Article
Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population.
Zhu X, Huang R, Hu P, Yan P, Zhai S, Zhang J, Zhuang J, Yin H, Meng T, Yang D, Huang Z
Med Sci Monit 2021 Feb 17;27:e929154. doi: 10.12659/MSM.929154. PMID: 33594036Free PMC Article
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone.
Wojcik J, Rosenberg AE, Bredella MA, Choy E, Hornicek FJ, Nielsen GP, Deshpande V
Am J Surg Pathol 2016 Jan;40(1):72-80. doi: 10.1097/PAS.0000000000000506. PMID: 26414220
Primary malignant giant cell tumor of bone: a series of three rare cases.
Kapoor SK, Jain V, Agrawal M, Singh S, Mandal AK
J Surg Orthop Adv 2007 Summer;16(2):89-92. PMID: 17592717

Prognosis

Malignant Giant Cell Tumor of Bone With a KRAS G12V Mutation.
Donigian S, Whiteway SL, Hipp SJ, Lybeck D, Clark RO
J Pediatr Hematol Oncol 2022 Jan 1;44(1):e268-e271. doi: 10.1097/MPH.0000000000002112. PMID: 33633024
Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy.
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article
Treatment and outcome of malignant giant cell tumor in the spine.
Yin H, Cheng M, Li B, Li B, Wang P, Meng T, Wang J, Zhou W, Yan W, Xiao J
J Neurooncol 2015 Sep;124(2):275-81. Epub 2015 Jun 4 doi: 10.1007/s11060-015-1835-9. PMID: 26040486
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature.
Shinjo K, Miyake N, Takahashi Y
Jpn J Clin Oncol 1993 Oct;23(5):317-24. PMID: 8230758

Clinical prediction guides

Systematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma.
Zhou Y, Ray PS, Zhu J, Stein F, Rettel M, Sekaran T, Sahadevan S, Perez-Perri JI, Roth EK, Myklebost O, Meza-Zepeda LA, von Deimling A, Fu C, Brosig AN, Boye K, Nathrath M, Blattmann C, Lehner B, Hentze MW, Kulozik AE
Nat Commun 2024 Apr 1;15(1):2810. doi: 10.1038/s41467-024-47031-y. PMID: 38561347Free PMC Article
Malignant giant cell tumor of toe: A case report and review of literature.
Hashimoto K, Nishimura S, Ito T, Akagi M
Medicine (Baltimore) 2022 Jun 3;101(22):e29471. doi: 10.1097/MD.0000000000029471. PMID: 35665736Free PMC Article
Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy.
Chen W, Yan Z, Tirumala V
J Orthop Res 2020 Oct;38(10):2139-2148. Epub 2020 Apr 22 doi: 10.1002/jor.24698. PMID: 32293747
Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone.
Righi A, Mancini I, Gambarotti M, Picci P, Gamberi G, Marraccini C, Dei Tos AP, Simi L, Pinzani P, Franchi A
Hum Pathol 2017 Oct;68:128-135. Epub 2017 Sep 9 doi: 10.1016/j.humpath.2017.08.033. PMID: 28899740
Primary de novo malignant giant cell tumor of kidney: a case report.
Kanthan R, Torkian B
BMC Urol 2004 Jun 18;4:7. doi: 10.1186/1471-2490-4-7. PMID: 15207006Free PMC Article

Recent systematic reviews

Malignancy in Giant Cell Tumor of Bone: A Review of the Literature.
Palmerini E, Picci P, Reichardt P, Downey G
Technol Cancer Res Treat 2019 Jan 1;18:1533033819840000. doi: 10.1177/1533033819840000. PMID: 30935298Free PMC Article

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