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Comedocarcinoma

MedGen UID:
90773
•Concept ID:
C0334370
•
Neoplastic Process
Synonyms: comedo carcinoma; comedocarcinoma
SNOMED CT: Comedocarcinoma (36425007)
 
Monarch Initiative: MONDO:0003575

Definition

A high grade carcinoma characterized by the presence of comedo-type tumor cell necrosis in which the necrotic areas are surrounded by a solid proliferation of malignant pleomorphic cells. [from NCI]

Professional guidelines

PubMed

Local recurrence after ductal carcinoma in situ breast conserving treatment. Analysis of 195 cases.
Cutuli B, Lemanski C, Le Blanc-Onfroy M, de Lafontan B, Cohen-Solal-Le-Nir C, Fondrinier E, Mignotte H, Giard S, Charra-Brunaud C, Auvray H, Gonzague-Casabianca L, Quétin P, Fay R
Cancer Radiother 2013 Jun;17(3):196-201. Epub 2013 Mar 26 doi: 10.1016/j.canrad.2013.01.011. PMID: 23538041
Surgical management of ductal carcinoma in situ in Australia in 1995.
Shugg D, White VM, Kitchen PR, Pruden M, Collins JP, Hill DJ
ANZ J Surg 2002 Oct;72(10):708-15. doi: 10.1046/j.1445-2197.2002.02532.x. PMID: 12534380
Nonpalpable in situ ductal carcinoma of the breast. Predictors of multicentricity and microinvasion and implications for treatment.
Schwartz GF, Patchefsky AS, Finklestein SD, Sohn SH, Prestipino A, Feig SA, Singer JS
Arch Surg 1989 Jan;124(1):29-32. doi: 10.1001/archsurg.1989.01410010035007. PMID: 2535928

Recent clinical studies

Etiology

Ultrasonographic detection and characterization of asymptomatic ductal carcinoma in situ with histopathologic correlation.
Gwak YJ, Kim HJ, Kwak JY, Lee SK, Shin KM, Lee HJ, Kim GC, Jang YJ, Han MH, Park JY, Jung JH
Acta Radiol 2011 May 1;52(4):364-71. Epub 2011 Mar 17 doi: 10.1258/ar.2011.100391. PMID: 21498298
Gestational breast cancer.
Samuels TH, Liu FF, Yaffe M, Haider M
Can Assoc Radiol J 1998 Jun;49(3):172-80. PMID: 9640283
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000
Surgical treatment of ductal carcinoma in situ of the breast. 10- to 20-year follow-up.
Simpson T, Thirlby RC, Dail DH
Arch Surg 1992 Apr;127(4):468-72. doi: 10.1001/archsurg.1992.01420040114020. PMID: 1313671
Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma.
Currin SM, Lee SE, Walther PJ
J Urol 1988 Jul;140(1):96-100. doi: 10.1016/s0022-5347(17)41496-0. PMID: 2837590

Diagnosis

Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy.
Franklin A, Delahunt B, Egevad L, Yaxley J, Johannsen S, Gianduzzo T, Ganter J, Pecoraro C, Thunders M, Samaratunga H
Pathology 2021 Feb;53(2):199-204. Epub 2020 Dec 29 doi: 10.1016/j.pathol.2020.10.009. PMID: 33386122
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists.
Shah RB, Li J, Cheng L, Egevad L, Deng FM, Fine SW, Kunju LP, Melamed J, Mehra R, Osunkoya AO, Paner GP, Shen SS, Tsuzuki T, Trpkov K, Tian W, Yang XJ, Zhou M
Am J Surg Pathol 2015 Sep;39(9):1242-9. doi: 10.1097/PAS.0000000000000442. PMID: 25929349
Detection method and breast carcinoma histology.
Newcomer LM, Newcomb PA, Trentham-Dietz A, Storer BE, Yasui Y, Daling JR, Potter JD
Cancer 2002 Aug 1;95(3):470-7. doi: 10.1002/cncr.10695. PMID: 12209738
Gestational breast cancer.
Samuels TH, Liu FF, Yaffe M, Haider M
Can Assoc Radiol J 1998 Jun;49(3):172-80. PMID: 9640283
Mammographic analysis of calcifications.
Bassett LW
Radiol Clin North Am 1992 Jan;30(1):93-105. PMID: 1732937

Therapy

Ductal carcinoma in situ of the breast: our experience.
Ruggiero R, Procaccini E, Sanguinetti A, Cremone C, Gili S, Docimo G, Docimo L, Sparavigna L, Gubitosi A, Parmeggiani D, Avenia N
G Chir 2009 Mar;30(3):121-4. PMID: 19351465
Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers' experience.
Cutuli B, Cohen-Solal-le Nir C, de Lafontan B, Mignotte H, Fichet V, Fay R, Servent V, Giard S, Charra-Brunaud C, Lemanski C, Auvray H, Jacquot S, Charpentier JC
Int J Radiat Oncol Biol Phys 2002 Jul 15;53(4):868-79. doi: 10.1016/s0360-3016(02)02834-1. PMID: 12095552
External beam irradiation plus (192)Ir implant after breast-preserving surgery in women with early breast cancer.
Moreno F, Guedea F, Lopez Y, Ferrer F, Gutierrez C, Petriz L, Pera J
Int J Radiat Oncol Biol Phys 2000 Oct 1;48(3):757-65. doi: 10.1016/s0360-3016(00)00676-3. PMID: 11020573
Radiation therapy for intraductal carcinoma. Is it an equal alternative?
Silverstein MJ, Waisman JR, Gierson ED, Colburn W, Gamagami P, Lewinsky BS
Arch Surg 1991 Apr;126(4):424-8. PMID: 1848972
Diagnostic problems in tissues previously sampled by fine-needle aspiration.
Tabbara SO, Frierson HF Jr, Fechner RE
Am J Clin Pathol 1991 Jul;96(1):76-80. doi: 10.1093/ajcp/96.1.76. PMID: 1648878

Prognosis

Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy.
Franklin A, Delahunt B, Egevad L, Yaxley J, Johannsen S, Gianduzzo T, Ganter J, Pecoraro C, Thunders M, Samaratunga H
Pathology 2021 Feb;53(2):199-204. Epub 2020 Dec 29 doi: 10.1016/j.pathol.2020.10.009. PMID: 33386122
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists.
Shah RB, Li J, Cheng L, Egevad L, Deng FM, Fine SW, Kunju LP, Melamed J, Mehra R, Osunkoya AO, Paner GP, Shen SS, Tsuzuki T, Trpkov K, Tian W, Yang XJ, Zhou M
Am J Surg Pathol 2015 Sep;39(9):1242-9. doi: 10.1097/PAS.0000000000000442. PMID: 25929349
Breast cancer.
Berg JW, Hutter RV
Cancer 1995 Jan 1;75(1 Suppl):257-69. doi: 10.1002/1097-0142(19950101)75:1+<257::aid-cncr2820751311>3.0.co;2-y. PMID: 8001000
Surgical treatment of ductal carcinoma in situ of the breast. 10- to 20-year follow-up.
Simpson T, Thirlby RC, Dail DH
Arch Surg 1992 Apr;127(4):468-72. doi: 10.1001/archsurg.1992.01420040114020. PMID: 1313671
Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma.
Currin SM, Lee SE, Walther PJ
J Urol 1988 Jul;140(1):96-100. doi: 10.1016/s0022-5347(17)41496-0. PMID: 2837590

Clinical prediction guides

Prognostic significance of morphological patterns of Gleason grade 5 prostatic adenocarcinoma diagnosed on needle biopsy.
Franklin A, Delahunt B, Egevad L, Yaxley J, Johannsen S, Gianduzzo T, Ganter J, Pecoraro C, Thunders M, Samaratunga H
Pathology 2021 Feb;53(2):199-204. Epub 2020 Dec 29 doi: 10.1016/j.pathol.2020.10.009. PMID: 33386122
Diagnosis of Gleason pattern 5 prostate adenocarcinoma on core needle biopsy: an interobserver reproducibility study among urologic pathologists.
Shah RB, Li J, Cheng L, Egevad L, Deng FM, Fine SW, Kunju LP, Melamed J, Mehra R, Osunkoya AO, Paner GP, Shen SS, Tsuzuki T, Trpkov K, Tian W, Yang XJ, Zhou M
Am J Surg Pathol 2015 Sep;39(9):1242-9. doi: 10.1097/PAS.0000000000000442. PMID: 25929349
Adenocarcinoma of the prostate with Gleason pattern 5 on core biopsy: frequency of diagnosis, morphologic subpatterns, and relation to pattern distribution based on the modified Gleason grading system.
Shah RB, Tadros Y
Hum Pathol 2014 Nov;45(11):2263-9. Epub 2014 Aug 7 doi: 10.1016/j.humpath.2014.07.012. PMID: 25228336
Histopathological review of sebaceous carcinoma of the eyelid.
Pereira PR, Odashiro AN, Rodrigues-Reyes AA, Correa ZM, de Souza Filho JP, Burnier MN Jr
J Cutan Pathol 2005 Aug;32(7):496-501. doi: 10.1111/j.0303-6987.2005.00371.x. PMID: 16008694
Stromal cellular response in breast tumours and allied lesions.
Hussain MA, Tyagi SP, Tyagi N, Khan MH
J Indian Med Assoc 1992 May;90(5):119-21. PMID: 1325527

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