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Modic type vertebral endplate changes

MedGen UID:: 907826
•Concept ID:: C4280778
•: Finding

HPO:	HP:0030775

Definition

An abnormal magnetic resonance tomography signal from a vertebral endplate according to a widely used classification published by Dr. Michael Modic. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVModic type vertebral endplate changes

Abnormality of the musculoskeletal system
- Abnormality of the skeletal system
  - Abnormal skeletal morphology
    - Abnormal axial skeleton morphology
      - Abnormality of the vertebral column
        Abnormal vertebral morphology
        Modic type vertebral endplate changes
        Modic type I vertebral endplate changes
        Modic type II vertebral endplate changes
        Modic type III vertebral endplate changes

Professional guidelines

PubMed

Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain: A Scoping Review of the Literature.

Schnapp W, Martiatu K, Delcroix GJ
Pain Physician 2022 Jul;25(4):E551-E562. PMID: 35793179

See all (1)

Recent clinical studies

Etiology

The impact of dyslipidemia on lumbar intervertebral disc degeneration and vertebral endplate modic changes: a cross-sectional study of 1035 citizens in China.

Yuan L, Huang Z, Han W, Chang R, Sun B, Zhu M, Li C, Yan J, Liu B, Yin H, Ye W
BMC Public Health 2023 Jul 6;23(1):1302. doi: 10.1186/s12889-023-16224-3. PMID: 37415123 Free PMC Article

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132 Free PMC Article

Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.

ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347

Modic Change: An Emerging Complication in the Aging Population.

Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981

Association Between Vertebral Dimensions and Lumbar Modic Changes.

Julin M, Saukkonen J, Oura P, Junno JA, Niemelä M, Määttä J, Niinimäki J, Jämsä T, Korpelainen R, Karppinen J
Spine (Phila Pa 1976) 2021 Apr 1;46(7):E415-E425. doi: 10.1097/BRS.0000000000003797. PMID: 33692323

See all (93)

Diagnosis

Degenerative disease of the spine: How to relate clinical symptoms to radiological findings.

Sąsiadek M, Jacków-Nowicka J
Adv Clin Exp Med 2024 Jan;33(1):91-98. doi: 10.17219/acem/163357. PMID: 37549011

A definition and clinical grading of Modic changes.

Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328

Modic Change: An Emerging Complication in the Aging Population.

Applebaum A, Nessim A, Cho W
Clin Spine Surg 2022 Feb 1;35(1):12-17. doi: 10.1097/BSD.0000000000001168. PMID: 33769981

Spondylodiscitis.

Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.

Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845 Free PMC Article

See all (59)

Therapy

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132 Free PMC Article

MRI image features with an evident relation to low back pain: a narrative review.

van der Graaf JW, Kroeze RJ, Buckens CFM, Lessmann N, van Hooff ML
Eur Spine J 2023 May;32(5):1830-1841. Epub 2023 Mar 9 doi: 10.1007/s00586-023-07602-x. PMID: 36892719

Modic Changes (MCs) Associated with Endplate Sclerosis Can Prevent Cage Subsidence in Oblique Lumbar Interbody Fusion (OLIF) Stand-Alone.

Liu J, Ding W, Yang D, Wu H, Hao L, Hu Z, Fan S, Zhao F
World Neurosurg 2020 Jun;138:e160-e168. Epub 2020 Feb 17 doi: 10.1016/j.wneu.2020.02.047. PMID: 32081816

Prevalence of vertebral endplate modic changes in degenerative lumbar scoliosis and its associated factors analysis.

Wu HL, Ding WY, Shen Y, Zhang YZ, Guo JK, Sun YP, Cao LZ
Spine (Phila Pa 1976) 2012 Nov 1;37(23):1958-64. doi: 10.1097/BRS.0b013e31825bfb85. PMID: 22565387

See all (34)

Prognosis

The disc-endplate-bone-marrow complex classification: progress in our understanding of Modic vertebral endplate changes and their clinical relevance.

Rajasekaran S, Bt P, Murugan C, Mengesha MG, Easwaran M, Naik AS, Ks SVA, Kanna RM, Shetty AP
Spine J 2024 Jan;24(1):34-45. Epub 2023 Sep 9 doi: 10.1016/j.spinee.2023.09.002. PMID: 37690481

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.

Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932

Presence of preoperative Modic changes and severity of endplate damage score are independent risk factors for developing postoperative surgical site infection: a retrospective case-control study of 1124 patients.

Pradip IA, Dilip Chand Raja S, Rajasekaran S, Sri Vijayanand KS, Shetty AP, Kanna RM, Thippeswamy PB
Eur Spine J 2021 Jun;30(6):1732-1743. Epub 2020 Sep 5 doi: 10.1007/s00586-020-06581-7. PMID: 32889553

The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.

Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955

Spondylodiscitis.

Márquez Sánchez P
Radiologia 2016 Apr;58 Suppl 1:50-9. Epub 2016 Feb 9 doi: 10.1016/j.rx.2015.12.005. PMID: 26869521

See all (36)

Clinical prediction guides

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.

Czaplewski LG, Rimmer O, McHale D, Laslett M
J Orthop Surg Res 2023 May 12;18(1):351. doi: 10.1186/s13018-023-03839-w. PMID: 37170132 Free PMC Article

Endplate and Facet Joint Changes in Cervical Spondylotic Myelopathy.

ElFiky T, Bessada B, Stienen MN, Siam AE, Hasan A
World Neurosurg 2023 Jul;175:e361-e366. Epub 2023 Mar 27 doi: 10.1016/j.wneu.2023.03.096. PMID: 36990347

Endplate abnormalities, Modic changes and their relationship to alignment parameters and surgical outcomes in the cervical spine.

Baker JD, Sayari AJ, Tao Y, Louie PK, Basques BA, Galbusera F, Niemeyer F, Wilke HJ, An HS, Samartzis D
J Orthop Res 2023 Jan;41(1):206-214. Epub 2022 Apr 10 doi: 10.1002/jor.25333. PMID: 35398932

A definition and clinical grading of Modic changes.

Udby PM, Samartzis D, Carreon LY, Andersen MØ, Karppinen J, Modic M
J Orthop Res 2022 Feb;40(2):301-307. Epub 2021 Dec 27 doi: 10.1002/jor.25240. PMID: 34910328

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.

Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845 Free PMC Article

See all (71)

Recent systematic reviews

The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Neurotomy for the Treatment of Chronic Low Back Pain in Patients with Modic Changes: A Systematic Review.

Conger A, Schuster NM, Cheng DS, Sperry BP, Joshi AB, Haring RS, Duszynski B, McCormick ZL
Pain Med 2021 May 21;22(5):1039-1054. doi: 10.1093/pm/pnab040. PMID: 33544851

The course of Modic vertebral body changes after posterolateral lumbar fusion on fused and adjacent levels: A systematic review of the literature.

Portella ST, Acioly MA
J Clin Neurosci 2017 Jul;41:6-10. Epub 2017 Apr 19 doi: 10.1016/j.jocn.2017.04.007. PMID: 28431955

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain.

Jensen TS, Karppinen J, Sorensen JS, Niinimäki J, Leboeuf-Yde C
Eur Spine J 2008 Nov;17(11):1407-22. Epub 2008 Sep 12 doi: 10.1007/s00586-008-0770-2. PMID: 18787845 Free PMC Article

See all (3)

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Modic type vertebral endplate changes

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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