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Prolonged central motor conduction time

MedGen UID:
908394
•Concept ID:
C4229185
•
Finding
HPO: HP:0034399

Definition

Increased duration of the central motor conduction time (CMCT). The CMCT estimates the conduction time of corticospinal fibers between motor cortex and spinal (or bulbar) motoneurons. It includes the times for excitation of cortical cells, conduction via the corticobulbar-corticospinal tract and excitation of the motoneuron sufficient to reach its firing threshold. CMCT is calculated by subtracting the peripheral conduction time from the MEP latency recorded after cortical stimulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProlonged central motor conduction time

Conditions with this feature

Hereditary spastic paraplegia 73
MedGen UID:
1800404
•Concept ID:
C5568981
•
Disease or Syndrome
A pure form of hereditary spastic paraplegia with characteristics of adult onset of crural spastic paraparesis, hyperreflexia, extensor plantar responses, proximal muscle weakness, mild muscle atrophy, decreased vibration sensation at ankles and mild urinary dysfunction. Foot deformities have been reported to eventually occur in some patients. No abnormalities are noted on brain magnetic resonance imaging and peripheral nerve conduction velocity studies.
See: Condition Record
Hereditary spastic paraplegia 73

Professional guidelines

PubMed

Clinical utility of electrophysiological evaluation in Crigler-Najjar syndrome.
Perretti A, Crispino G, Marcantonio L, Lenta S, Caropreso M, Manganelli F, Scianguetta S, Iorio R, Iolascon A, Vajro P
Neuropediatrics 2007 Aug;38(4):173-8. doi: 10.1055/s-2007-991147. PMID: 18058623

Recent clinical studies

Etiology

Cortical hyperexcitability evolves with disease progression in ALS.
Menon P, Higashihara M, van den Bos M, Geevasinga N, Kiernan MC, Vucic S
Ann Clin Transl Neurol 2020 May;7(5):733-741. Epub 2020 Apr 18 doi: 10.1002/acn3.51039. PMID: 32304186Free PMC Article
Use of Central Motor Conduction Time and Spinal Cord Evoked Potentials in the Electrophysiological Assessment of Compressive Cervical Myelopathy.
Fujimoto K, Kanchiku T, Imajo Y, Suzuki H, Funaba M, Nishida N, Taguchi T
Spine (Phila Pa 1976) 2017 Jun 15;42(12):895-902. doi: 10.1097/BRS.0000000000001939. PMID: 27792117
The electrophysiology of spinocerebellar ataxias.
Liang L, Chen T, Wu Y
Neurophysiol Clin 2016 Feb;46(1):27-34. Epub 2016 Mar 2 doi: 10.1016/j.neucli.2015.12.006. PMID: 26947625
The pseudopolyneuritic form of amyotrophic lateral sclerosis (Patrikios' disease).
Cappellari A, Ciammola A, Silani V
Electromyogr Clin Neurophysiol 2008 Mar;48(2):75-81. PMID: 18435211
Corticospinal tract conduction block results in the prolongation of central motor conduction time in compressive cervical myelopathy.
Nakanishi K, Tanaka N, Fujiwara Y, Kamei N, Ochi M
Clin Neurophysiol 2006 Mar;117(3):623-7. Epub 2006 Jan 25 doi: 10.1016/j.clinph.2005.11.010. PMID: 16442342

Diagnosis

The evolution of motor cortical dysfunction in amyotrophic lateral sclerosis.
Shibuya K, Simon NG, Geevasinga N, Menon P, Howells J, Park SB, Huynh W, Noto YI, Vucic S, Kiernan MC
Clin Neurophysiol 2017 Jun;128(6):1075-1082. Epub 2017 Mar 15 doi: 10.1016/j.clinph.2017.03.004. PMID: 28400096
Use of Central Motor Conduction Time and Spinal Cord Evoked Potentials in the Electrophysiological Assessment of Compressive Cervical Myelopathy.
Fujimoto K, Kanchiku T, Imajo Y, Suzuki H, Funaba M, Nishida N, Taguchi T
Spine (Phila Pa 1976) 2017 Jun 15;42(12):895-902. doi: 10.1097/BRS.0000000000001939. PMID: 27792117
The electrophysiology of spinocerebellar ataxias.
Liang L, Chen T, Wu Y
Neurophysiol Clin 2016 Feb;46(1):27-34. Epub 2016 Mar 2 doi: 10.1016/j.neucli.2015.12.006. PMID: 26947625
The pseudopolyneuritic form of amyotrophic lateral sclerosis (Patrikios' disease).
Cappellari A, Ciammola A, Silani V
Electromyogr Clin Neurophysiol 2008 Mar;48(2):75-81. PMID: 18435211
Clinical and physiological significance of abnormally prolonged central motor conduction time in HAM/TSP.
Shimizu H, Shiga Y, Fujihara K, Ohnuma A, Itoyama Y
J Neurol Sci 2001 Mar 15;185(1):39-42. doi: 10.1016/s0022-510x(01)00455-5. PMID: 11266689

Therapy

Neurotoxicity of nitrous oxide: multimodal evoked potentials in an abuser.
Lin CY, Guo WY, Chen SP, Chen JT, Kao KP, Wu ZA, Liao KK
Clin Toxicol (Phila) 2007;45(1):67-71. doi: 10.1080/15563650600795792. PMID: 17357386

Prognosis

Prolonged central motor conduction time and pyramidal tract degeneration in amyotrophic lateral sclerosis.
Takeda T, Iijima M, Seki M, Higuchi E, Shimizu Y, Shibata N, Kitagawa K
Clin Neuropathol 2022 Jul-Aug;41(4):157-161. doi: 10.5414/NP301438. PMID: 35343426
Use of Central Motor Conduction Time and Spinal Cord Evoked Potentials in the Electrophysiological Assessment of Compressive Cervical Myelopathy.
Fujimoto K, Kanchiku T, Imajo Y, Suzuki H, Funaba M, Nishida N, Taguchi T
Spine (Phila Pa 1976) 2017 Jun 15;42(12):895-902. doi: 10.1097/BRS.0000000000001939. PMID: 27792117
The pseudopolyneuritic form of amyotrophic lateral sclerosis (Patrikios' disease).
Cappellari A, Ciammola A, Silani V
Electromyogr Clin Neurophysiol 2008 Mar;48(2):75-81. PMID: 18435211
Clinical utility of electrophysiological evaluation in Crigler-Najjar syndrome.
Perretti A, Crispino G, Marcantonio L, Lenta S, Caropreso M, Manganelli F, Scianguetta S, Iorio R, Iolascon A, Vajro P
Neuropediatrics 2007 Aug;38(4):173-8. doi: 10.1055/s-2007-991147. PMID: 18058623
Motor-evoked potentials in response to fatiguing grip exercise in multiple sclerosis patients.
Petajan JH, White AT
Clin Neurophysiol 2000 Dec;111(12):2188-95. doi: 10.1016/s1388-2457(00)00469-7. PMID: 11090771

Clinical prediction guides

Prolonged central motor conduction time and pyramidal tract degeneration in amyotrophic lateral sclerosis.
Takeda T, Iijima M, Seki M, Higuchi E, Shimizu Y, Shibata N, Kitagawa K
Clin Neuropathol 2022 Jul-Aug;41(4):157-161. doi: 10.5414/NP301438. PMID: 35343426
Use of Central Motor Conduction Time and Spinal Cord Evoked Potentials in the Electrophysiological Assessment of Compressive Cervical Myelopathy.
Fujimoto K, Kanchiku T, Imajo Y, Suzuki H, Funaba M, Nishida N, Taguchi T
Spine (Phila Pa 1976) 2017 Jun 15;42(12):895-902. doi: 10.1097/BRS.0000000000001939. PMID: 27792117
TMS-induced motor evoked potentials in Wilson's disease: a systematic literature review.
Bembenek JP, Kurczych K, Członkowska A
Bioelectromagnetics 2015 Apr;36(4):255-66. Epub 2015 Mar 23 doi: 10.1002/bem.21909. PMID: 25808411
The pseudopolyneuritic form of amyotrophic lateral sclerosis (Patrikios' disease).
Cappellari A, Ciammola A, Silani V
Electromyogr Clin Neurophysiol 2008 Mar;48(2):75-81. PMID: 18435211
Mechanism of prolonged central motor conduction time in compressive cervical myelopathy.
Kaneko K, Taguchi T, Morita H, Yonemura H, Fujimoto H, Kawai S
Clin Neurophysiol 2001 Jun;112(6):1035-40. doi: 10.1016/s1388-2457(01)00533-8. PMID: 11377262

Recent systematic reviews

TMS-induced motor evoked potentials in Wilson's disease: a systematic literature review.
Bembenek JP, Kurczych K, Członkowska A
Bioelectromagnetics 2015 Apr;36(4):255-66. Epub 2015 Mar 23 doi: 10.1002/bem.21909. PMID: 25808411

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