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External ear cancer

MedGen UID:
91157
•Concept ID:
C0349576
•
Neoplastic Process
Synonyms: cancer of external ear; external ear cancer; Malignant External Auditory Canal Neoplasm; Malignant External Ear Neoplasm; malignant external Ear neoplasm; malignant external ear neoplasm; Malignant External Ear Tumor; malignant external Ear tumor; malignant external Ear tumour; Malignant Neoplasm of External Ear; malignant neoplasm of external ear; malignant neoplasm of external Ear; Malignant Neoplasm of the External Ear; malignant neoplasm of the external Ear; malignant neoplasm of the external ear; Malignant tumor of external ear; Malignant Tumor of External Ear; malignant tumor of external Ear; Malignant Tumor of the External Ear; malignant tumor of the external Ear; malignant tumour of external Ear; malignant tumour of the external Ear
SNOMED CT: Malignant tumor of external ear (277156006)
 
Monarch Initiative: MONDO:0003574

Definition

A malignant neoplasm that affects the external ear. Representative examples include squamous cell carcinoma, basal cell carcinoma, and ceruminous adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Treatment Strategies for Malignancies of the External Auditory Canal.
Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Overactive Surveillance: Is "Conservative" Management for Low-risk Prostate Cancer Too Aggressive?
Loeb S
Eur Urol 2019 Oct;76(4):467-468. Epub 2019 May 4 doi: 10.1016/j.eururo.2019.04.003. PMID: 31060823
Clinical management for T1 and T2 external auditory canal cancer.
Shinomiya H, Uehara N, Teshima M, Kakigi A, Otsuki N, Nibu KI
Auris Nasus Larynx 2019 Oct;46(5):785-789. Epub 2019 Feb 21 doi: 10.1016/j.anl.2019.02.004. PMID: 30799138

Recent clinical studies

Etiology

Dermoscopy of external ear melanoma (EEM).
Kaminska-Winciorek G, Slowinska M, Krotowski J, Nasierowska-Guttmejer A, Musial J, Cybulska-Stopa B
Arch Dermatol Res 2023 Jul;315(5):1381-1387. Epub 2022 Mar 17 doi: 10.1007/s00403-022-02342-2. PMID: 35298674
Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Malignant lesions of the ear.
Tammaro A, Adebanjo GAR, Chello C, Parisella FR, Cantisani C, Farnetani F, Pellacani G
Arch Dermatol Res 2022 Nov;314(9):839-845. Epub 2021 Nov 18 doi: 10.1007/s00403-021-02304-0. PMID: 34792642
Postauricular Masses.
Tasli H, Gokgoz MC, Karakoc O
J Craniofac Surg 2020 Sep;31(6):e555-e560. doi: 10.1097/SCS.0000000000006526. PMID: 32604279
Ear defects.
Shonka DC Jr, Park SS
Facial Plast Surg Clin North Am 2009 Aug;17(3):429-43. doi: 10.1016/j.fsc.2009.05.006. PMID: 19698921

Diagnosis

Neoplasms of the Ear Canal.
Raymond M
Otolaryngol Clin North Am 2023 Oct;56(5):965-976. Epub 2023 Jul 24 doi: 10.1016/j.otc.2023.06.003. PMID: 37495430
Ear canal and middle-ear tumors: a single-institution series of 87 patients.
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Imaging the External Ear: Practical Approach to Normal and Pathologic Conditions.
Tsuno NSG, Tsuno MY, Coelho Neto CAF, Noujaim SE, Decnop M, Pacheco FT, Souza SA, Fonseca APA, Garcia MRT
Radiographics 2022 Mar-Apr;42(2):522-540. Epub 2022 Feb 4 doi: 10.1148/rg.210148. PMID: 35119966
Postauricular Masses.
Tasli H, Gokgoz MC, Karakoc O
J Craniofac Surg 2020 Sep;31(6):e555-e560. doi: 10.1097/SCS.0000000000006526. PMID: 32604279
Ceruminous Neoplasms of the Ear.
Nagarajan P
Head Neck Pathol 2018 Sep;12(3):350-361. Epub 2018 Aug 1 doi: 10.1007/s12105-018-0909-3. PMID: 30069843Free PMC Article

Therapy

Dasatinib with intensive chemotherapy in de novo paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (CA180-372/COG AALL1122): a single-arm, multicentre, phase 2 trial.
Hunger SP, Tran TH, Saha V, Devidas M, Valsecchi MG, Gastier-Foster JM, Cazzaniga G, Reshmi SC, Borowitz MJ, Moorman AV, Heerema NA, Carroll AJ, Martin-Regueira P, Loh ML, Raetz EA, Schultz KR, Slayton WB, Cario G, Schrappe M, Silverman LB, Biondi A
Lancet Haematol 2023 Jul;10(7):e510-e520. doi: 10.1016/S2352-3026(23)00088-1. PMID: 37407142
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Irradiated ears in nasopharyngeal carcinoma survivors: A review.
Young YH
Laryngoscope 2019 Mar;129(3):637-642. Epub 2018 Sep 8 doi: 10.1002/lary.27303. PMID: 30194730
Vagolysis.
Hutchinson CD, Jardine DL, Hurrell M
Age Ageing 2008 Sep;37(5):602-4. Epub 2008 Jun 12 doi: 10.1093/ageing/afn105. PMID: 18556705
Craniofacial osseointegration.
Granström G
Oral Dis 2007 May;13(3):261-9. doi: 10.1111/j.1601-0825.2007.01365.x. PMID: 17448206

Prognosis

Treatment Strategies for Malignancies of the External Auditory Canal.
Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Malignant lesions of the ear.
Tammaro A, Adebanjo GAR, Chello C, Parisella FR, Cantisani C, Farnetani F, Pellacani G
Arch Dermatol Res 2022 Nov;314(9):839-845. Epub 2021 Nov 18 doi: 10.1007/s00403-021-02304-0. PMID: 34792642
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187
A systematic review on external ear melanoma.
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418
Vagolysis.
Hutchinson CD, Jardine DL, Hurrell M
Age Ageing 2008 Sep;37(5):602-4. Epub 2008 Jun 12 doi: 10.1093/ageing/afn105. PMID: 18556705

Clinical prediction guides

Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
GBD 2021 Causes of Death Collaborators
Lancet 2024 May 18;403(10440):2100-2132. Epub 2024 Apr 3 doi: 10.1016/S0140-6736(24)00367-2. PMID: 38582094Free PMC Article
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk sequencing data.
Wang W, Zhao H, Wang S
Front Immunol 2023;14:1099071. Epub 2023 Jan 30 doi: 10.3389/fimmu.2023.1099071. PMID: 36793711Free PMC Article
External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes.
Correia-Rodrigues P, Ramalho S, Montalvão P, Magalhães M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2709-2720. Epub 2020 May 4 doi: 10.1007/s00405-020-06019-2. PMID: 32367152
Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
Burton KA, Ashack KA, Khachemoune A
Am J Clin Dermatol 2016 Oct;17(5):491-508. doi: 10.1007/s40257-016-0207-3. PMID: 27358187

Recent systematic reviews

Clinical Approaches To External Auditory Canal Hemangiomas: A Systematic Review.
Alshalan A, Khurayzi T, Assiri M, Alsanosi A
Ear Nose Throat J 2024 Feb;103(2):90-99. Epub 2021 Aug 24 doi: 10.1177/01455613211042449. PMID: 34427123
Artificial Intelligence in Head and Neck Cancer: A Systematic Review of Systematic Reviews.
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Skull Base Leiomyomas and Angioleiomyomas: A Systematic Literature Review and an Uncommon Case Report.
Rincon-Torroella J, Snyder MH, Galaiya DJ, Morris M, Weingart JD, Stewart CM
World Neurosurg 2021 Oct;154:154-166.e1. Epub 2021 Jun 26 doi: 10.1016/j.wneu.2021.06.096. PMID: 34182177Free PMC Article
Cerebellopontine Angle and Internal Auditory Canal Lipomas: Case Series and Systematic Review.
Totten DJ, Manzoor NF, Perkins EL, Labadie RF, Bennett ML, Haynes DS
Laryngoscope 2021 Sep;131(9):2081-2087. Epub 2021 Feb 10 doi: 10.1002/lary.29434. PMID: 33567134
A systematic review on external ear melanoma.
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418

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