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Uterine Corpus Endometrial Stromal and Related Neoplasms

MedGen UID:
925583
•Concept ID:
C4288051
•
Neoplastic Process
Synonym: Uterine Corpus Endometrial Stromal and Related Tumors

Definition

A category of benign or malignant mesenchymal neoplasms that arises from the uterine corpus. This category includes the endometrial stromal nodule which is benign and non-invasive, the endometrial stromal sarcoma, and the undifferentiated uterine sarcoma. The endometrial stromal sarcoma is an invasive malignant neoplasm, further subdivided into low grade and high grade endometrial stromal sarcoma. Undifferentiated uterine sarcoma was previously also known as high grade endometrial stromal sarcoma. In 2014, high grade endometrial stromal sarcoma was reclassified and is currently considered a distinct and rare neoplasm. It appears to have a prognosis that falls between low grade endometrial stromal sarcoma and undifferentiated sarcoma. [from NCI]

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750

Recent clinical studies

Etiology

Analysis of long non-coding RNAs associated with disulfidptosis for prognostic signature and immunotherapy response in uterine corpus endometrial carcinoma.
Li B, Li X, Ma M, Wang Q, Shi J, Wu C
Sci Rep 2023 Dec 14;13(1):22220. doi: 10.1038/s41598-023-49750-6. PMID: 38097686Free PMC Article
Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
Jiao Y, Geng R, Zhong Z, Ni S, Liu W, He Z, Gan S, Huang Q, Liu J, Bai J
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021675. PMID: 36675190Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
A multi-institutional review of outcomes of endometrial stromal sarcoma.
Leath CA 3rd, Huh WK, Hyde J Jr, Cohn DE, Resnick KE, Taylor NP, Powell MA, Mutch DG, Bradley WH, Geller MA, Argenta PA, Gold MA
Gynecol Oncol 2007 Jun;105(3):630-4. Epub 2007 Feb 23 doi: 10.1016/j.ygyno.2007.01.031. PMID: 17320937

Diagnosis

Pan-cancer analysis reveals the characteristics and roles of tooth agenesis mutant genes.
Liu Y, Yang J, Li X, Chen S, Zhu C, Shi Y, Dang S, Zhang W, Li W
Medicine (Baltimore) 2023 Dec 15;102(50):e36001. doi: 10.1097/MD.0000000000036001. PMID: 38115305Free PMC Article
Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
Jiao Y, Geng R, Zhong Z, Ni S, Liu W, He Z, Gan S, Huang Q, Liu J, Bai J
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021675. PMID: 36675190Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387
Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects.
Clement PB, Young RH
Adv Anat Pathol 2002 May;9(3):145-84. doi: 10.1097/00125480-200205000-00001. PMID: 11981113

Therapy

Analysis of long non-coding RNAs associated with disulfidptosis for prognostic signature and immunotherapy response in uterine corpus endometrial carcinoma.
Li B, Li X, Ma M, Wang Q, Shi J, Wu C
Sci Rep 2023 Dec 14;13(1):22220. doi: 10.1038/s41598-023-49750-6. PMID: 38097686Free PMC Article
Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association.
Segala D, Gobbo S, Pesci A, Martignoni G, Santoro A, Angelico G, Arciuolo D, Spadola S, Valente M, Scambia G, Zannoni GF
Pathol Res Pract 2019 May;215(5):1089-1092. Epub 2019 Jan 28 doi: 10.1016/j.prp.2019.01.039. PMID: 30799070

Prognosis

Pan-cancer analysis reveals the characteristics and roles of tooth agenesis mutant genes.
Liu Y, Yang J, Li X, Chen S, Zhu C, Shi Y, Dang S, Zhang W, Li W
Medicine (Baltimore) 2023 Dec 15;102(50):e36001. doi: 10.1097/MD.0000000000036001. PMID: 38115305Free PMC Article
Analysis of long non-coding RNAs associated with disulfidptosis for prognostic signature and immunotherapy response in uterine corpus endometrial carcinoma.
Li B, Li X, Ma M, Wang Q, Shi J, Wu C
Sci Rep 2023 Dec 14;13(1):22220. doi: 10.1038/s41598-023-49750-6. PMID: 38097686Free PMC Article
A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
Jiao Y, Geng R, Zhong Z, Ni S, Liu W, He Z, Gan S, Huang Q, Liu J, Bai J
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021675. PMID: 36675190Free PMC Article
Clinical Implications of Aberrant PD-1 and CTLA4 Expression for Cancer Immunity and Prognosis: A Pan-Cancer Study.
Liu JN, Kong XS, Huang T, Wang R, Li W, Chen QF
Front Immunol 2020;11:2048. Epub 2020 Sep 10 doi: 10.3389/fimmu.2020.02048. PMID: 33072070Free PMC Article
Recent Developments in Surgical Pathology of the Uterine Corpus.
Hanley KZ, Birdsong GG, Mosunjac MB
Arch Pathol Lab Med 2017 Apr;141(4):528-541. Epub 2017 Feb 28 doi: 10.5858/arpa.2016-0284-SA. PMID: 28353387

Clinical prediction guides

Pan-cancer analysis reveals the characteristics and roles of tooth agenesis mutant genes.
Liu Y, Yang J, Li X, Chen S, Zhu C, Shi Y, Dang S, Zhang W, Li W
Medicine (Baltimore) 2023 Dec 15;102(50):e36001. doi: 10.1097/MD.0000000000036001. PMID: 38115305Free PMC Article
Analysis of long non-coding RNAs associated with disulfidptosis for prognostic signature and immunotherapy response in uterine corpus endometrial carcinoma.
Li B, Li X, Ma M, Wang Q, Shi J, Wu C
Sci Rep 2023 Dec 14;13(1):22220. doi: 10.1038/s41598-023-49750-6. PMID: 38097686Free PMC Article
A Hypoxia Molecular Signature-Based Prognostic Model for Endometrial Cancer Patients.
Jiao Y, Geng R, Zhong Z, Ni S, Liu W, He Z, Gan S, Huang Q, Liu J, Bai J
Int J Mol Sci 2023 Jan 14;24(2) doi: 10.3390/ijms24021675. PMID: 36675190Free PMC Article
Mixed Endometrioid Adenocarcinoma and Müllerian Adenosarcoma of the Uterus and Ovary: Clinicopathologic Characterization With Emphasis on its Distinction From Carcinosarcoma.
El Hallani S, Arora R, Lin DI, Måsbäc A, Mateoiu C, McCluggage WG, Nucci MR, Otis CN, Parkash V, Parra-Herran C, Longacre TA
Am J Surg Pathol 2021 Mar 1;45(3):374-383. doi: 10.1097/PAS.0000000000001643. PMID: 33565764
Clinical Implications of Aberrant PD-1 and CTLA4 Expression for Cancer Immunity and Prognosis: A Pan-Cancer Study.
Liu JN, Kong XS, Huang T, Wang R, Li W, Chen QF
Front Immunol 2020;11:2048. Epub 2020 Sep 10 doi: 10.3389/fimmu.2020.02048. PMID: 33072070Free PMC Article

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