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Oropharyngeal Basaloid Carcinoma

MedGen UID:
926083
•Concept ID:
C4288551
•
Neoplastic Process

Definition

A high-grade variant of squamous cell carcinoma that arises from the oropharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOropharyngeal Basaloid Carcinoma

Professional guidelines

PubMed

Oropharyngeal Squamous Cell Carcinoma in 390 Patients: Analysis of Clinical and Histological Criteria Which Significantly Impact Outcome.
Thompson LDR, Burchette R, Iganej S, Bhattasali O
Head Neck Pathol 2020 Sep;14(3):666-688. Epub 2019 Nov 18 doi: 10.1007/s12105-019-01096-0. PMID: 31741151Free PMC Article
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Recent clinical studies

Etiology

Utility of p16 and HPV testing in oropharyngeal squamous cell carcinoma: An institutional review.
Abdelhakam DA, Huenerberg KA, Nassar A
Diagn Cytopathol 2021 Jan;49(1):54-59. Epub 2020 Aug 26 doi: 10.1002/dc.24593. PMID: 32845095
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Basaloid squamous cell carcinoma of the head and neck: report of 18 cases.
Choussy O, Bertrand M, François A, Blot E, Hamidou H, Dehesdin D
J Laryngol Otol 2011 Jun;125(6):608-13. Epub 2011 Mar 30 doi: 10.1017/S0022215111000491. PMID: 21450130

Diagnosis

Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Therapy

New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Biologic importance and prognostic significance of selected clinicopathological parameters in patients with oral and oropharyngeal squamous cell carcinoma, with emphasis on smoking, protein p16(INK4a) expression, and HPV status.
Laco J, Nekvindova J, Novakova V, Celakovsky P, Dolezalova H, Tucek L, Vosmikova H, Vosmik M, Neskudlova T, Cermakova E, Hacova M, Sobande FA, Ryska A
Neoplasma 2012;59(4):398-408. doi: 10.4149/neo_2012_052. PMID: 22489695
HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior.
Kraft S, Faquin WC, Krane JF
Am J Surg Pathol 2012 Mar;36(3):321-30. doi: 10.1097/PAS.0b013e31823f2f17. PMID: 22301491
Role of human papillomavirus in the development of head and neck squamous cell carcinomas.
Hafkamp HC, Manni JJ, Speel EJ
Acta Otolaryngol 2004 May;124(4):520-6. doi: 10.1080/00016480310016893. PMID: 15224887
Different risk factors in basaloid and common squamous head and neck cancer.
Kleist B, Bankau A, Lorenz G, Jäger B, Poetsch M
Laryngoscope 2004 Jun;114(6):1063-8. doi: 10.1097/00005537-200406000-00020. PMID: 15179214

Prognosis

Utility of p16 and HPV testing in oropharyngeal squamous cell carcinoma: An institutional review.
Abdelhakam DA, Huenerberg KA, Nassar A
Diagn Cytopathol 2021 Jan;49(1):54-59. Epub 2020 Aug 26 doi: 10.1002/dc.24593. PMID: 32845095
Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
Wenig BM
Mod Pathol 2017 Jan;30(s1):S112-S118. doi: 10.1038/modpathol.2016.207. PMID: 28060368
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
HPV-related squamous cell carcinoma variants in the head and neck.
El-Mofty SK
Head Neck Pathol 2012 Jul;6 Suppl 1(Suppl 1):S55-62. Epub 2012 Jul 3 doi: 10.1007/s12105-012-0363-6. PMID: 22782224Free PMC Article
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Clinical prediction guides

Utility of p16 and HPV testing in oropharyngeal squamous cell carcinoma: An institutional review.
Abdelhakam DA, Huenerberg KA, Nassar A
Diagn Cytopathol 2021 Jan;49(1):54-59. Epub 2020 Aug 26 doi: 10.1002/dc.24593. PMID: 32845095
Oropharyngeal Squamous Cell Carcinoma in 390 Patients: Analysis of Clinical and Histological Criteria Which Significantly Impact Outcome.
Thompson LDR, Burchette R, Iganej S, Bhattasali O
Head Neck Pathol 2020 Sep;14(3):666-688. Epub 2019 Nov 18 doi: 10.1007/s12105-019-01096-0. PMID: 31741151Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

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