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Crescentic glomerulonephritis

MedGen UID:
96040
•Concept ID:
C0403416
•
Disease or Syndrome
Synonym: Crescentic glomerulonephritis (disease)
SNOMED CT: Proliferative crescentic glomerulonephritis (236398000); Idiopathic crescentic glomerulonephritis (236398000); Crescentic glomerulonephritis (236398000); CGN - Crescentic glomerulonephritis (236398000)
 
HPO: HP:0008653
Monarch Initiative: MONDO:0001645

Definition

A type of extracapillary glomerulonephritis characterized by the formation of crescent-like cellular proliferation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Crescentic glomerulonephritis
  • Crescentic glomerulonephritis
    • Crescentic glomerulonephritis
      • Crescentic glomerulonephritis
        • Crescentic glomerulonephritis
          • Crescentic glomerulonephritis
            • Crescentic glomerulonephritis
              • Crescentic glomerulonephritis

Conditions with this feature

Autoimmune interstitial lung disease-arthritis syndrome
MedGen UID:
1800821
•Concept ID:
C5243948
•
Disease or Syndrome
Autoimmune interstitial lung, joint, and kidney disease is an autosomal dominant systemic autoimmune disorder characterized by interstitial lung disease, inflammatory arthritis, and immune complex-mediated renal disease. Laboratory studies show high-titer autoantibodies. Symptoms appear in the first 2 decades of life, but there is incomplete penetrance (summary by Watkin et al., 2015).
See: Condition Record
Autoimmune interstitial lung disease-arthritis syndrome

Professional guidelines

PubMed

Diagnostic and management challenges in Goodpasture's (anti-glomerular basement membrane) disease.
Henderson SR, Salama AD
Nephrol Dial Transplant 2018 Feb 1;33(2):196-202. doi: 10.1093/ndt/gfx057. PMID: 28459999
Rapidly progressive crescentic glomerulonephritis: Early treatment is a must.
Moroni G, Ponticelli C
Autoimmun Rev 2014 Jul;13(7):723-9. Epub 2014 Mar 19 doi: 10.1016/j.autrev.2014.02.007. PMID: 24657897
Management of crescentic glomerulonephritis: what are the recent advances?
Li X, Chen N
Contrib Nephrol 2013;181:229-39. Epub 2013 May 8 doi: 10.1159/000348479. PMID: 23689584

Recent clinical studies

Etiology

Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis.
Toda E, Sawada A, Takeuchi K, Wakamatsu K, Ishikawa A, Kuwahara N, Sawa Y, Hatanaka S, Kokubo K, Makino K, Takahashi H, Endo Y, Kunugi S, Terasaki M, Terasaki Y, Matsushima K, Terashima Y, Shimizu A
Kidney Int 2022 Dec;102(6):1276-1290. Epub 2022 Aug 30 doi: 10.1016/j.kint.2022.07.031. PMID: 36049642
Parietal epithelial cell dysfunction in crescentic glomerulonephritis.
Wong MN, Tharaux PL, Grahammer F, Puelles VG
Cell Tissue Res 2021 Aug;385(2):345-354. Epub 2021 Aug 28 doi: 10.1007/s00441-021-03513-9. PMID: 34453566Free PMC Article
Crescentic glomerulonephritis in children.
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Etiology and outcome of crescentic glomerulonephritis.
Sinha A, Puri K, Hari P, Dinda AK, Bagga A
Indian Pediatr 2013 Mar;50(3):283-8. Epub 2012 Aug 5 doi: 10.1007/s13312-013-0095-z. PMID: 23024099
Renal vasculitis.
Balow JE
Curr Opin Nephrol Hypertens 1993 Mar;2(2):231-7. doi: 10.1097/00041552-199303000-00009. PMID: 7922182

Diagnosis

Goodpasture syndrome and anti-glomerular basement membrane disease.
Reggiani F, L'Imperio V, Calatroni M, Pagni F, Sinico RA
Clin Exp Rheumatol 2023 Apr;41(4):964-974. Epub 2023 Mar 30 doi: 10.55563/clinexprheumatol/tep3k5. PMID: 36995324
Crescentic glomerulonephritis in children.
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zonozi R, Niles JL, Cortazar FB
Rheum Dis Clin North Am 2018 Nov;44(4):525-543. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.001. PMID: 30274621
Fortuitous vasculitis.
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755
Antineutrophil cytoplasmic antibodies.
Bosch X, Guilabert A, Font J
Lancet 2006 Jul 29;368(9533):404-18. doi: 10.1016/S0140-6736(06)69114-9. PMID: 16876669

Therapy

Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice.
Melica ME, Antonelli G, Semeraro R, Angelotti ML, Lugli G, Landini S, Ravaglia F, Regina G, Conte C, De Chiara L, Peired AJ, Mazzinghi B, Donati M, Molli A, Steiger S, Magi A, Bartalucci N, Raglianti V, Guzzi F, Maggi L, Annunziato F, Burger A, Lazzeri E, Anders HJ, Lasagni L, Romagnani P
Sci Transl Med 2022 Aug 10;14(657):eabg3277. doi: 10.1126/scitranslmed.abg3277. PMID: 35947676Free PMC Article
Adult-onset IgA vasculitis (Henoch-Schönlein): Update on therapy.
Maritati F, Canzian A, Fenaroli P, Vaglio A
Presse Med 2020 Oct;49(3):104035. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104035. PMID: 32645417
Crescentic glomerulonephritis in children.
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Anti-CD20 therapy and pauci-immune crescentic glomerulonephritis.
Shu KH, Chiang WC, Chiu YL
J Formos Med Assoc 2017 Apr;116(4):215-216. Epub 2016 Jan 16 doi: 10.1016/j.jfma.2015.12.003. PMID: 26786252
Fortuitous vasculitis.
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755

Prognosis

Adult-onset IgA vasculitis (Henoch-Schönlein): Update on therapy.
Maritati F, Canzian A, Fenaroli P, Vaglio A
Presse Med 2020 Oct;49(3):104035. Epub 2020 Jul 6 doi: 10.1016/j.lpm.2020.104035. PMID: 32645417
Crescentic glomerulonephritis in children.
Mayer U, Schmitz J, Bräsen JH, Pape L
Pediatr Nephrol 2020 May;35(5):829-842. Epub 2020 Feb 12 doi: 10.1007/s00467-019-04436-y. PMID: 32052153Free PMC Article
Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Zonozi R, Niles JL, Cortazar FB
Rheum Dis Clin North Am 2018 Nov;44(4):525-543. Epub 2018 Sep 7 doi: 10.1016/j.rdc.2018.06.001. PMID: 30274621
Fortuitous vasculitis.
Sharma H, Keshavan A, Little MA, Cross J, Lipman MC, Talukdar S, Hopkins S
Ren Fail 2012;34(3):378-82. Epub 2012 Jan 17 doi: 10.3109/0886022X.2011.647337. PMID: 22250755
Pauci-immune crescentic glomerulonephritis.
Gupta RK
Indian J Pathol Microbiol 2003 Jul;46(3):357-66. PMID: 15025274

Clinical prediction guides

Role of MCP-1 as an inflammatory biomarker in nephropathy.
Liu Y, Xu K, Xiang Y, Ma B, Li H, Li Y, Shi Y, Li S, Bai Y
Front Immunol 2023;14:1303076. Epub 2024 Jan 4 doi: 10.3389/fimmu.2023.1303076. PMID: 38239353Free PMC Article
Stimulation of Immune Checkpoint Molecule B and T-Lymphocyte Attenuator Alleviates Experimental Crescentic Glomerulonephritis.
Diefenhardt P, Braumann M, Schömig T, Trinsch B, Sierra Gonzalez C, Becker-Gotot J, Völker LA, Ester L, Mandel AM, Hawiger D, Abdallah AT, Schermer B, Göbel H, Brinkkötter P, Kurts C, Benzing T, Brähler S
J Am Soc Nephrol 2023 Aug 1;34(8):1366-1380. Epub 2023 Jun 26 doi: 10.1681/ASN.0000000000000159. PMID: 37367205Free PMC Article
Inhibition of the chemokine signal regulator FROUNT by disulfiram ameliorates crescentic glomerulonephritis.
Toda E, Sawada A, Takeuchi K, Wakamatsu K, Ishikawa A, Kuwahara N, Sawa Y, Hatanaka S, Kokubo K, Makino K, Takahashi H, Endo Y, Kunugi S, Terasaki M, Terasaki Y, Matsushima K, Terashima Y, Shimizu A
Kidney Int 2022 Dec;102(6):1276-1290. Epub 2022 Aug 30 doi: 10.1016/j.kint.2022.07.031. PMID: 36049642
Complement in ANCA-associated vasculitis: mechanisms and implications for management.
Chen M, Jayne DRW, Zhao MH
Nat Rev Nephrol 2017 Jun;13(6):359-367. Epub 2017 Mar 20 doi: 10.1038/nrneph.2017.37. PMID: 28316335
Complement in ANCA-associated vasculitis.
Charles Jennette J, Xiao H, Hu P
Semin Nephrol 2013 Nov;33(6):557-64. doi: 10.1016/j.semnephrol.2013.08.006. PMID: 24161040Free PMC Article

Recent systematic reviews

Epidemiology, clinical features, risk factors, and outcomes in anti-glomerular basement membrane disease: A systematic review and meta-analysis.
Kuang H, Jiang N, Jia XY, Cui Z, Zhao MH
Autoimmun Rev 2024 Apr;23(4):103531. Epub 2024 Mar 16 doi: 10.1016/j.autrev.2024.103531. PMID: 38493958
Diffuse alveolar hemorrhage in IgA nephropathy: case series and systematic review of the literature.
Rajagopala S, Parameswaran S, Ajmera JS, Ganesh RN, Katrevula A
Int J Rheum Dis 2017 Jan;20(1):109-121. Epub 2016 Feb 4 doi: 10.1111/1756-185X.12818. PMID: 26845236
Anti-glomerular basement membrane antibody disease treated with rituximab: A case-based review.
Syeda UA, Singer NG, Magrey M
Semin Arthritis Rheum 2013 Jun;42(6):567-72. Epub 2013 Jan 24 doi: 10.1016/j.semarthrit.2012.10.007. PMID: 23352254
Pauci-immune crescentic glomerulonephritis in limited cutaneous systemic sclerosis.
Chan PT, Mok CC
Clin Rheumatol 2012 Aug;31(8):1273-7. Epub 2012 May 30 doi: 10.1007/s10067-012-2010-8. PMID: 22644090

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