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Central posterior corneal opacity

MedGen UID:
96093
•Concept ID:
C0423260
•
Finding
SNOMED CT: Central posterior corneal opacity (246967007)
 
HPO: HP:0008511

Definition

Reduced transparency of the central posterior portion of the corneal stroma. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral posterior corneal opacity

Conditions with this feature

Keratoconus posticus circumscriptus
MedGen UID:
340922
•Concept ID:
C1855645
•
Disease or Syndrome
See: Condition Record
Keratoconus posticus circumscriptus

Recent clinical studies

Etiology

Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Influence of corneal guttae and nuclear cataract on contrast sensitivity.
Augustin VA, Weller JM, Kruse FE, Tourtas T
Br J Ophthalmol 2021 Oct;105(10):1365-1370. Epub 2020 Sep 9 doi: 10.1136/bjophthalmol-2019-315206. PMID: 32907813
Corneal higher-order aberrations in phlyctenular keratitis.
Katayama T, Yagi-Yaguchi Y, Ibrahim O, Shimazaki J, Yamaguchi T
Jpn J Ophthalmol 2020 Sep;64(5):478-484. Epub 2020 Jul 18 doi: 10.1007/s10384-020-00759-8. PMID: 32683555
Peters anomaly: A 5-year experience.
Salik I, Gupta A, Tara A, Zaidman G, Barst S
Paediatr Anaesth 2020 May;30(5):577-583. Epub 2020 Mar 16 doi: 10.1111/pan.13843. PMID: 32107814
Analysis of the Corneal Anterior and Posterior Surface in Patients With Peripheral Hypertrophic Subepithelial Corneal Opacification.
Riedl JC, Musayeva A, Wasielica-Poslednik J, Weyer-Elberich V, Pfeiffer N, Gericke A
Eye Contact Lens 2020 Mar;46(2):105-109. doi: 10.1097/ICL.0000000000000615. PMID: 31009396

Diagnosis

Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis.
Kumar DA, Agarwal A, Chandrasekar R, Chinnappan RM
Indian J Ophthalmol 2022 Apr;70(4):1197-1202. doi: 10.4103/ijo.IJO_2073_21. PMID: 35326015Free PMC Article
Bilateral posterior central corneal steepening with decreased visual acuity.
Moshirfar M, Conley ME, Sugar J, Afshari N, Moon J, Bowden E, Kim G, Karimian F, Murri M, Jacob S
J Cataract Refract Surg 2022 Apr 1;48(4):508-512. doi: 10.1097/j.jcrs.0000000000000926. PMID: 35318296
Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Influence of corneal guttae and nuclear cataract on contrast sensitivity.
Augustin VA, Weller JM, Kruse FE, Tourtas T
Br J Ophthalmol 2021 Oct;105(10):1365-1370. Epub 2020 Sep 9 doi: 10.1136/bjophthalmol-2019-315206. PMID: 32907813
Corneal Scheimpflug Densitometry in Photorefractive Keratectomy Candidates.
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpur E, Aghamirsalim M, Hashemi H
Cornea 2020 Nov;39(11):1381-1388. doi: 10.1097/ICO.0000000000002468. PMID: 33017121

Therapy

Corneal Scheimpflug Densitometry in Photorefractive Keratectomy Candidates.
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpur E, Aghamirsalim M, Hashemi H
Cornea 2020 Nov;39(11):1381-1388. doi: 10.1097/ICO.0000000000002468. PMID: 33017121
Corneal topometric, aberrometric and biomechanical parameters in mucopolysaccharidosis patients.
Wasielica-Poslednik J, Schuster AK, Politino G, Marx-Gross S, Bell K, Pfeiffer N, Pitz S
PLoS One 2019;14(6):e0218108. Epub 2019 Jun 27 doi: 10.1371/journal.pone.0218108. PMID: 31246979Free PMC Article
Single-piece femtosecond-assisted mushroom keratoplasty in children.
Elkamshoushy A, Gonnah R, Madi S, Beltz J
J AAPOS 2019 Feb;23(1):28.e1-28.e5. Epub 2018 Nov 27 doi: 10.1016/j.jaapos.2018.08.009. PMID: 30500436
Impact of Forward and Backward Scattering and Corneal Higher-Order Aberrations on Visual Acuity after Penetrating Keratoplasty.
Kobashi H, Kamiya K, Shimizu K
Semin Ophthalmol 2018;33(6):748-756. Epub 2018 Jan 16 doi: 10.1080/08820538.2018.1427767. PMID: 29336641
Should unilateral congenital corneal opacities in Peters' anomaly be grafted?
Basdekidou C, Dureau P, Edelson C, De Laage De Meux P, Caputo G
Eur J Ophthalmol 2011 Nov-Dec;21(6):695-9. doi: 10.5301/EJO.2011.6317. PMID: 21298629

Prognosis

Ten-year follow-up of posterior chamber phakic intraocular lens with central port design in patients with low and normal vault.
Alfonso-Bartolozzi B, Fernández-Vega-Cueto L, Lisa C, Palacios A, Madrid-Costa D, Alfonso JF
J Cataract Refract Surg 2024 May 1;50(5):441-447. doi: 10.1097/j.jcrs.0000000000001379. PMID: 38085219
Bilateral posterior central corneal steepening with decreased visual acuity.
Moshirfar M, Conley ME, Sugar J, Afshari N, Moon J, Bowden E, Kim G, Karimian F, Murri M, Jacob S
J Cataract Refract Surg 2022 Apr 1;48(4):508-512. doi: 10.1097/j.jcrs.0000000000000926. PMID: 35318296
Varied Presentations of Posterior Keratoconus: A Clinical Case Series.
Ganesan N, Narayana S, Kasturi N, Kaliaperumal S, Srinivasan R, Vallinayagam M
Cornea 2020 Nov;39(11):1348-1353. doi: 10.1097/ICO.0000000000002455. PMID: 32833850
Morphological and biometric features of preexisting posterior capsule defect in congenital cataract.
Li Z, Chang P, Wang D, Zhao Y, Hu M, Ding X, Yu L, Zhao Y
J Cataract Refract Surg 2018 Jul;44(7):871-877. doi: 10.1016/j.jcrs.2018.05.009. PMID: 30055693
Impact of Forward and Backward Scattering and Corneal Higher-Order Aberrations on Visual Acuity after Penetrating Keratoplasty.
Kobashi H, Kamiya K, Shimizu K
Semin Ophthalmol 2018;33(6):748-756. Epub 2018 Jan 16 doi: 10.1080/08820538.2018.1427767. PMID: 29336641

Clinical prediction guides

Congenital Corneal Opacity in 22q11.2 Deletion Syndrome: A Case Series.
Franco E, Iqbal N, Shah PR, Alabek M, Tripi KS, Prescott C, Scanga HL, Chu CT, Nischal KK
Cornea 2023 Mar 1;42(3):344-350. Epub 2022 Nov 30 doi: 10.1097/ICO.0000000000003155. PMID: 36455075
Semilunar sign of cornea: A multimodal analysis of the posterior corneal opacity in non-infectious anterior scleritis.
Kumar DA, Agarwal A, Chandrasekar R, Chinnappan RM
Indian J Ophthalmol 2022 Apr;70(4):1197-1202. doi: 10.4103/ijo.IJO_2073_21. PMID: 35326015Free PMC Article
Ocular Phenotype of Peters-Plus Syndrome.
Shah PR, Chauhan B, Chu CT, Kofler J, Nischal KK
Cornea 2022 Feb 1;41(2):219-223. doi: 10.1097/ICO.0000000000002889. PMID: 34629439
Morphological and biometric features of preexisting posterior capsule defect in congenital cataract.
Li Z, Chang P, Wang D, Zhao Y, Hu M, Ding X, Yu L, Zhao Y
J Cataract Refract Surg 2018 Jul;44(7):871-877. doi: 10.1016/j.jcrs.2018.05.009. PMID: 30055693
Characterization of a central corneal cloudiness sharing features of posterior crocodile shagreen and central cloud dystrophy of François.
Meyer JC, Quantock AJ, Thonar EJ, Kincaid MC, Hageman GS, Assil KK
Cornea 1996 Jul;15(4):347-54. doi: 10.1097/00003226-199607000-00003. PMID: 8776559

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