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Smokers keratosis

MedGen UID:
97999
•Concept ID:
C0399478
•
Disease or Syndrome
Synonym: Smoker's Keratosis
SNOMED CT: Smokers keratosis (235033006)

Definition

A premalignant pathologic process that affects the oral mucosa. It is associated with the use of smoked tobacco. It appears as white lesions on the oral mucosa. Morphologically it is characterized by the pathologic production of keratin in the mucosal epithelial surface with or without epithelial atypia. It may reverse with the cessation of tobacco use. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmokers keratosis

Professional guidelines

PubMed

Risk Assessment of Smokeless Tobacco among Oral Precancer and Cancer Patients in Eastern Developmental Region of Nepal.
Rimal J, Shrestha A, Maharjan IK, Shrestha S, Shah P
Asian Pac J Cancer Prev 2019 Feb 26;20(2):411-415. doi: 10.31557/APJCP.2019.20.2.411. PMID: 30803200Free PMC Article
Treatment with laser CO2 cordectomy and clinical implications in management of mild and moderate laryngeal precancerosis.
Minni A, Barbaro M, Rispoli G, Diaferia F, Bernardeschi D, Filipo R
Eur Arch Otorhinolaryngol 2008 Feb;265(2):189-93. Epub 2007 Oct 26 doi: 10.1007/s00405-007-0480-0. PMID: 17962972

Recent clinical studies

Etiology

Hearing outcome after tympanoplasty type III.
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
Müller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):591-602. Epub 2018 Mar 1 doi: 10.1016/j.oooo.2018.02.012. PMID: 29606637
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882

Diagnosis

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
Müller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):591-602. Epub 2018 Mar 1 doi: 10.1016/j.oooo.2018.02.012. PMID: 29606637
Oral leukoplakia, the ongoing discussion on definition and terminology.
van der Waal I
Med Oral Patol Oral Cir Bucal 2015 Nov 1;20(6):e685-92. doi: 10.4317/medoral.21007. PMID: 26449439Free PMC Article
Laryngeal precancer: a review of the literature, commentary, and comparison with oral leukoplakia.
Bouquot JE, Gnepp DR
Head Neck 1991 Nov-Dec;13(6):488-97. doi: 10.1002/hed.2880130604. PMID: 1791144

Therapy

Clinicopathological Evaluation of Tobacco-related Oral Mucosal Lesions.
Gabhane MH, Hemagiriyappa MS, Sharma VJ, Pardeshi KV, Rai BA, Nahar P
J Contemp Dent Pract 2022 Apr 1;23(4):399-404. PMID: 35945832
Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
Müller S
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Jun;125(6):591-602. Epub 2018 Mar 1 doi: 10.1016/j.oooo.2018.02.012. PMID: 29606637
Khat chewing and smoking effect on oral mucosa: a clinical study.
Halboub E, Dhaifullah E, Abdulhuq M
Acta Medica (Hradec Kralove) 2009;52(4):155-8. doi: 10.14712/18059694.2016.122. PMID: 20369709
Oral changes associated with tobacco use.
Taybos G
Am J Med Sci 2003 Oct;326(4):179-82. doi: 10.1097/00000441-200310000-00005. PMID: 14557730
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882

Prognosis

Hearing outcome after tympanoplasty type III.
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Alveolar ridge keratosis--a retrospective clinicopathological study.
Bellato L, Martinelli-Kläy CP, Martinelli CR, Lombardi T
Head Face Med 2013 Apr 16;9:12. doi: 10.1186/1746-160X-9-12. PMID: 23587097Free PMC Article
Premalignant epithelium and microinvasive cancer of the vocal fold: the evolution of phonomicrosurgical management.
Zeitels SM
Laryngoscope 1995 Mar;105(3 Pt 2):1-51. doi: 10.1288/00005537-199503001-00001. PMID: 7885166
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882
Laryngeal precancer: a review of the literature, commentary, and comparison with oral leukoplakia.
Bouquot JE, Gnepp DR
Head Neck 1991 Nov-Dec;13(6):488-97. doi: 10.1002/hed.2880130604. PMID: 1791144

Clinical prediction guides

Hearing outcome after tympanoplasty type III.
Tihanyi A, Speck I, Wolff K, Arnold P, Aschendorff A, Arndt S
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4353-4362. Epub 2022 Jan 24 doi: 10.1007/s00405-021-07190-w. PMID: 35072768Free PMC Article
Behavioral and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients.
Fania L, Abeni D, Esposito I, Spagnoletti G, Citterio F, Romagnoli J, Castriota M, Ricci F, Moro F, Perino F, Mazzanti C, De Simone C, Peris K
G Ital Dermatol Venereol 2020 Oct;155(5):669-675. Epub 2018 Sep 24 doi: 10.23736/S0392-0488.18.06099-6. PMID: 30251802
Alveolar ridge keratosis--a retrospective clinicopathological study.
Bellato L, Martinelli-Kläy CP, Martinelli CR, Lombardi T
Head Face Med 2013 Apr 16;9:12. doi: 10.1186/1746-160X-9-12. PMID: 23587097Free PMC Article
Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas.
Stevens HP, Kelsell DP, Bryant SP, Bishop DT, Spurr NK, Weissenbach J, Marger D, Marger RS, Leigh IM
Arch Dermatol 1996 Jun;132(6):640-51. PMID: 8651714
Tobacco use and cancer. A reappraisal.
Vigneswaran N, Tilashalski K, Rodu B, Cole P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995 Aug;80(2):178-82. doi: 10.1016/s1079-2104(05)80199-4. PMID: 7552882

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