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Mononeuropathy

MedGen UID:
99214
•Concept ID:
C0494491
•
Disease or Syndrome
Synonym: Mononeuropathies
SNOMED CT: Mononeuropathy (128189008)
 
HPO: HP:0009831
Monarch Initiative: MONDO:0001397

Definition

A focal lesion of a single peripheral nerve. Damage to a sensory nerve is accompanied by sensory impairment of all modalities in the affected anatomic distribution. [from HPO]

Conditions with this feature

Susceptibility to mononeuropathy of the median nerve, mild
MedGen UID:
461946
•Concept ID:
C3150596
•
Disease or Syndrome
See: Condition Record
Susceptibility to mononeuropathy of the median nerve, mild

Professional guidelines

PubMed

Guiding Treatment for Carpal Tunnel Syndrome.
Wang L
Phys Med Rehabil Clin N Am 2018 Nov;29(4):751-760. Epub 2018 Sep 17 doi: 10.1016/j.pmr.2018.06.009. PMID: 30293628
The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review.
Callaghan BC, Price RS, Chen KS, Feldman EL
JAMA Neurol 2015 Dec;72(12):1510-8. doi: 10.1001/jamaneurol.2015.2347. PMID: 26437251Free PMC Article
Clinical practice guideline: Bell's palsy.
Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, Deckard NA, Dawson C, Driscoll C, Gillespie MB, Gurgel RK, Halperin J, Khalid AN, Kumar KA, Micco A, Munsell D, Rosenbaum S, Vaughan W
Otolaryngol Head Neck Surg 2013 Nov;149(3 Suppl):S1-27. doi: 10.1177/0194599813505967. PMID: 24189771

Recent clinical studies

Etiology

Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Musculocutaneous neuropathy.
O'Gorman CM, Kassardjian C, Sorenson EJ
Muscle Nerve 2018 Nov;58(5):726-729. Epub 2018 Aug 22 doi: 10.1002/mus.26186. PMID: 30028506
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Diabetic neuropathy.
Charnogursky G, Lee H, Lopez N
Handb Clin Neurol 2014;120:773-85. doi: 10.1016/B978-0-7020-4087-0.00051-6. PMID: 24365351
Clinical practice guideline: Bell's palsy.
Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, Deckard NA, Dawson C, Driscoll C, Gillespie MB, Gurgel RK, Halperin J, Khalid AN, Kumar KA, Micco A, Munsell D, Rosenbaum S, Vaughan W
Otolaryngol Head Neck Surg 2013 Nov;149(3 Suppl):S1-27. doi: 10.1177/0194599813505967. PMID: 24189771

Diagnosis

Radial neuropathy.
Chalk C
Handb Clin Neurol 2024;201:127-134. doi: 10.1016/B978-0-323-90108-6.00015-6. PMID: 38697735
Peripheral nervous system involvement in systemic lupus erythematosus: a review of the evidence.
Bortoluzzi A, Silvagni E, Furini F, Piga M, Govoni M
Clin Exp Rheumatol 2019 Jan-Feb;37(1):146-155. Epub 2018 May 24 PMID: 29846158
Guiding Treatment for Carpal Tunnel Syndrome.
Wang L
Phys Med Rehabil Clin N Am 2018 Nov;29(4):751-760. Epub 2018 Sep 17 doi: 10.1016/j.pmr.2018.06.009. PMID: 30293628
Neuroborreliosis.
Halperin JJ
J Neurol 2017 Jun;264(6):1292-1297. Epub 2016 Nov 24 doi: 10.1007/s00415-016-8346-2. PMID: 27885483
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963

Therapy

Neurologic Complications of Lyme Disease.
Roos KL
Continuum (Minneap Minn) 2021 Aug 1;27(4):1040-1050. doi: 10.1212/CON.0000000000001015. PMID: 34623103
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Postsurgical Neuropathy: A Descriptive Review.
Laughlin RS, Johnson RL, Burkle CM, Staff NP
Mayo Clin Proc 2020 Feb;95(2):355-369. doi: 10.1016/j.mayocp.2019.05.038. PMID: 32029088
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article
The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review.
Callaghan BC, Price RS, Chen KS, Feldman EL
JAMA Neurol 2015 Dec;72(12):1510-8. doi: 10.1001/jamaneurol.2015.2347. PMID: 26437251Free PMC Article

Prognosis

Femoral and obturator neuropathies.
Chalk C, Zaloum A
Handb Clin Neurol 2024;201:183-194. doi: 10.1016/B978-0-323-90108-6.00007-7. PMID: 38697739
Radial neuropathy.
Chalk C
Handb Clin Neurol 2024;201:127-134. doi: 10.1016/B978-0-323-90108-6.00015-6. PMID: 38697735
Mononeuropathies in pregnancy.
Massey EW, Massey JM
Handb Clin Neurol 2020;172:145-151. doi: 10.1016/B978-0-444-64240-0.00008-8. PMID: 32768085
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963

Clinical prediction guides

Peripheral neuropathy and livedoid vasculopathy.
Soulages A, Maisonobe T, Auzou P, Petit A, Allenbach Y, Barète S, Skopinski S, Ribeiro E, Jullié ML, Lamant L, Brevet F, Soulages X, Vallat JM, Martin-Négrier ML, Solé G, Duval F, Carla L, Le Masson G, Mathis S
J Neurol 2022 Jul;269(7):3779-3788. Epub 2022 Feb 15 doi: 10.1007/s00415-022-11007-z. PMID: 35166926
Mononeuropathies in pregnancy.
Massey EW, Massey JM
Handb Clin Neurol 2020;172:145-151. doi: 10.1016/B978-0-444-64240-0.00008-8. PMID: 32768085
Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.
Shem K, Wong J, Dirlikov B
J Hand Ther 2020 Jul-Sep;33(3):272-280. Epub 2020 May 1 doi: 10.1016/j.jht.2019.12.002. PMID: 32362377
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article

Recent systematic reviews

Hormone replacement therapy in women and risk of carpal tunnel syndrome: a systematic review and metaanalysis.
Manosroi W, Atthakomol P, Phinyo P, Danpanichkul P
J Orthop Traumatol 2023 Jun 12;24(1):26. doi: 10.1186/s10195-023-00707-5. PMID: 37308714Free PMC Article
Preoperative electrodiagnostic studies and postoperative outcomes for ulnar mononeuropathy at the elbow: A systematic review.
Meiling JB, Schappell JB, Twohey EE, Prokop LJ, Cushman DM
PM R 2023 Oct;15(10):1326-1334. Epub 2023 Feb 24 doi: 10.1002/pmrj.12952. PMID: 36730149
Ultrasound-guided percutaneous carpal tunnel release: A systematic review.
Chou RC, Robinson DM, Homer S
PM R 2023 Mar;15(3):363-379. Epub 2022 May 16 doi: 10.1002/pmrj.12801. PMID: 35254722
Acupuncture for the Treatment of Peripheral Neuropathy: A Systematic Review and Meta-Analysis.
Dimitrova A, Murchison C, Oken B
J Altern Complement Med 2017 Mar;23(3):164-179. Epub 2017 Jan 23 doi: 10.1089/acm.2016.0155. PMID: 28112552Free PMC Article
Neurologic involvement in scleroderma: a systematic review.
Amaral TN, Peres FA, Lapa AT, Marques-Neto JF, Appenzeller S
Semin Arthritis Rheum 2013 Dec;43(3):335-47. Epub 2013 Jul 1 doi: 10.1016/j.semarthrit.2013.05.002. PMID: 23827688

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