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Ciliary body cancer

MedGen UID:
99219
•Concept ID:
C0496833
•
Neoplastic Process
Synonyms: cancer of ciliary body; ciliary body cancer; Malignant Ciliary Body Neoplasm; malignant ciliary body neoplasm; Malignant Ciliary Body Tumor; malignant ciliary body tumor; malignant ciliary body tumour; Malignant neoplasm of ciliary body; Malignant Neoplasm of Ciliary Body; malignant neoplasm of ciliary body; Malignant Neoplasm of the Ciliary Body; malignant neoplasm of the ciliary body; Malignant tumor of ciliary body; Malignant Tumor of Ciliary Body; malignant tumor of ciliary body; Malignant Tumor of the Ciliary Body; malignant tumor of the ciliary body; malignant tumour of ciliary body; malignant tumour of the ciliary body
SNOMED CT: Malignant neoplasm of ciliary body (188263008); Malignant tumor of ciliary body (188263008)
 
Monarch Initiative: MONDO:0002969

Definition

A malignant neoplasm that affects the ciliary body. Representative examples include melanoma and malignant medulloepithelioma. [from NCI]

Professional guidelines

PubMed

Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article

Recent clinical studies

Etiology

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775
Iris melanoma.
Henderson E, Margo CE
Arch Pathol Lab Med 2008 Feb;132(2):268-72. doi: 10.5858/2008-132-268-IM. PMID: 18251588

Diagnosis

Adenomas of the ciliary body epithelium: clinics, histopathology and management.
Zheng Y, Gu X, Yao Y, Pan H, Jia R, Xu X, Zhuang A
Br J Ophthalmol 2024 May 21;108(6):826-832. doi: 10.1136/bjo-2023-323845. PMID: 37433648
Surgical Approach in Intraocular Tumors.
Gündüz AK, Mirzayev I
Turk J Ophthalmol 2022 Apr 28;52(2):125-138. doi: 10.4274/tjo.galenos.2021.24376. PMID: 35481734Free PMC Article
Diagnosis and long-term monitoring of adenomas of the ciliary body epithelium by ultrasound biomicroscopy.
Méndez-Martínez S, Santiago Varela M, Blanco-Teijeiro MJ, Piñeiro-Ces A
Eur J Ophthalmol 2021 Jul;31(4):2032-2041. Epub 2020 Aug 24 doi: 10.1177/1120672120952645. PMID: 32830591
Congenital uveal melanoma?
Singh AD, Schoenfield LA, Bastian BC, Aziz HA, Marino MJ, Biscotti CV
Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12 doi: 10.1016/j.survophthal.2015.07.005. PMID: 26277063
Ocular neurofibromatosis.
Brownstein S, Little JM
Ophthalmology 1983 Dec;90(12):1595-9. doi: 10.1016/s0161-6420(83)34371-2. PMID: 6429597

Therapy

Robotic CyberKnife Radiosurgery for the Treatment of Choroidal and Ciliary Body Melanoma.
Liegl R, Schmelter V, Fuerweger C, Ehret F, Priglinger S, Muacevic A, Foerster P
Am J Ophthalmol 2023 Jun;250:177-185. Epub 2023 Jan 13 doi: 10.1016/j.ajo.2022.12.021. PMID: 36642391
Iris and ciliary body cysts and phakic intraocular lenses.
Gharaibeh AM, Liehneova I, Mojzis P, Ziak P, Alió JL
Eur J Ophthalmol 2020 Sep;30(5):974-977. Epub 2019 Sep 23 doi: 10.1177/1120672119876532. PMID: 31544491
Glaucoma secondary to intraocular tumors: mechanisms and management.
Camp DA, Yadav P, Dalvin LA, Shields CL
Curr Opin Ophthalmol 2019 Mar;30(2):71-81. doi: 10.1097/ICU.0000000000000550. PMID: 30562240
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Obesity: new perspectives and pharmacotherapies.
Palamara KL, Mogul HR, Peterson SJ, Frishman WH
Cardiol Rev 2006 Sep-Oct;14(5):238-58. doi: 10.1097/01.crd.0000233903.57946.fd. PMID: 16924165

Prognosis

DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP
Mod Pathol 2022 Jan;35(1):4-22. Epub 2021 Oct 1 doi: 10.1038/s41379-021-00905-8. PMID: 34599283Free PMC Article
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Metastatic disease from uveal melanoma: treatment options and future prospects.
Carvajal RD, Schwartz GK, Tezel T, Marr B, Francis JH, Nathan PD
Br J Ophthalmol 2017 Jan;101(1):38-44. Epub 2016 Aug 29 doi: 10.1136/bjophthalmol-2016-309034. PMID: 27574175Free PMC Article
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Ocular melanoma.
Laver NV, McLaughlin ME, Duker JS
Arch Pathol Lab Med 2010 Dec;134(12):1778-84. doi: 10.5858/2009-0441-RAR.1. PMID: 21128775

Clinical prediction guides

Iris melanoma: Prognostication for metastasis.
Melendez-Moreno A, Yeşiltaş YS, Wrenn J, Singh AD
Surv Ophthalmol 2023 Sep-Oct;68(5):957-963. Epub 2023 May 18 doi: 10.1016/j.survophthal.2023.05.006. PMID: 37207703
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR
Pediatr Radiol 2019 Oct;49(11):1488-1505. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04429-x. PMID: 31620849
Uveal Melanoma Treatment and Prognostication.
Dogrusöz M, Jager MJ, Damato B
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):186-196. doi: 10.22608/APO.201734. PMID: 28399342
Uveal melanoma: relatively rare but deadly cancer.
Kaliki S, Shields CL
Eye (Lond) 2017 Feb;31(2):241-257. Epub 2016 Dec 2 doi: 10.1038/eye.2016.275. PMID: 27911450Free PMC Article
Uveal melanoma: estimating prognosis.
Kaliki S, Shields CL, Shields JA
Indian J Ophthalmol 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367. PMID: 25827538Free PMC Article

Recent systematic reviews

Meta-analysis on the utility of radiotherapy for the treatment of Ocular Melanoma.
Messineo D, Barile G, Morrone S, La Torre G, Turchetti P, Accetta L, Trovato Battagliola E, Agostinelli E, Pacella F
Clin Ter 2020 Jan-Feb;170(1):e89-e98. doi: 10.7417/CT.2020.2195. PMID: 31916427
Glaucoma due to ciliary body cysts and pseudoplateau iris: a systematic review of the literature.
Schmalfuss TR, Picetti E, Pakter HM
Arq Bras Oftalmol 2018 Jun;81(3):254-261. doi: 10.5935/0004-2749.20180051. PMID: 29924202
Characterization, treatment, and outcome of uveal melanoma in the first two years of life.
Yousef YA, Alkilany M
Hematol Oncol Stem Cell Ther 2015 Mar;8(1):1-5. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.004. PMID: 25300563
Diagnostic performance of magnetic resonance imaging and computed tomography for advanced retinoblastoma: a systematic review and meta-analysis.
de Jong MC, de Graaf P, Noij DP, Göricke S, Maeder P, Galluzzi P, Brisse HJ, Moll AC, Castelijns JA; European Retinoblastoma Imaging Collaboration (ERIC)
Ophthalmology 2014 May;121(5):1109-18. Epub 2014 Mar 1 doi: 10.1016/j.ophtha.2013.11.021. PMID: 24589388
Uveal melanoma: trends in incidence, treatment, and survival.
Singh AD, Turell ME, Topham AK
Ophthalmology 2011 Sep;118(9):1881-5. Epub 2011 Jun 24 doi: 10.1016/j.ophtha.2011.01.040. PMID: 21704381

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