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Carcinogen effect in offspring

MedGen UID:
99251
•Concept ID:
C0520760
•
Pathologic Function
Synonym: Carcinogen Effect in Offspring
SNOMED CT: Carcinogen effect in offspring (64579005)

Definition

Alteration of any condition or process in an offspring that results form the effect of a carcinogen in a parent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinogen effect in offspring

Professional guidelines

PubMed

Risk assessment of dioxins and dioxin-like PCBs in food--comments by the German Federal Environmental Agency.
Gies A, Neumeier G, Rappolder M, Konietzka R
Chemosphere 2007 Apr;67(9):S344-9. Epub 2007 Jan 16 doi: 10.1016/j.chemosphere.2006.05.128. PMID: 17223171
Genotype-environment interaction in transmission disequilibrium tests.
Eaves LJ, Sullivan P
Adv Genet 2001;42:223-40. doi: 10.1016/s0065-2660(01)42025-6. PMID: 11037324
Evaluation and management of diethylstilbestrol-exposed offspring.
Hajj SN, Herbst AL
Surg Clin North Am 1978 Feb;58(1):87-96. doi: 10.1016/s0039-6109(16)41436-2. PMID: 347605

Recent clinical studies

Etiology

Maternal electronic cigarette exposure in relation to offspring development: a comprehensive review.
Zhang Y, Angley M, Qi X, Lu L, D'Alton ME, Kahe K
Am J Obstet Gynecol MFM 2022 Sep;4(5):100659. Epub 2022 May 11 doi: 10.1016/j.ajogmf.2022.100659. PMID: 35568317
Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring.
Al Jishi T, Sergi C
Reprod Toxicol 2017 Aug;71:71-77. Epub 2017 Apr 28 doi: 10.1016/j.reprotox.2017.04.009. PMID: 28461243
Diethylstilbestrol: Potential health risks for women exposed in utero and their offspring.
Conlon JL
JAAPA 2017 Feb;30(2):49-52. doi: 10.1097/01.JAA.0000511800.91372.34. PMID: 28098674
Carcinogenic risks of prenatal ionizing radiation.
Brent RL
Semin Fetal Neonatal Med 2014 Jun;19(3):203-13. Epub 2013 Dec 27 doi: 10.1016/j.siny.2013.11.009. PMID: 24378676
Diethylstilbestrol exposure.
Schrager S, Potter BE
Am Fam Physician 2004 May 15;69(10):2395-400. PMID: 15168959

Diagnosis

Parental Age and Risk of Infant Leukaemia: A Pooled Analysis.
Marcotte EL, Druley TE, Johnson KJ, Richardson M, von Behren J, Mueller BA, Carozza S, McLaughlin C, Chow EJ, Reynolds P, Spector LG
Paediatr Perinat Epidemiol 2017 Nov;31(6):563-572. Epub 2017 Sep 22 doi: 10.1111/ppe.12412. PMID: 28940632Free PMC Article
Current perspective of diethylstilbestrol (DES) exposure in mothers and offspring.
Al Jishi T, Sergi C
Reprod Toxicol 2017 Aug;71:71-77. Epub 2017 Apr 28 doi: 10.1016/j.reprotox.2017.04.009. PMID: 28461243
Carcinogenic risks of prenatal ionizing radiation.
Brent RL
Semin Fetal Neonatal Med 2014 Jun;19(3):203-13. Epub 2013 Dec 27 doi: 10.1016/j.siny.2013.11.009. PMID: 24378676
Polychlorinated biphenyls (PCBs) and human health: an update.
Kimbrough RD
Crit Rev Toxicol 1995;25(2):133-63. doi: 10.3109/10408449509021611. PMID: 7612174
The current status of the DES-exposed population.
Herbst AL
Obstet Gynecol Annu 1981;10:267-78. PMID: 7024873

Therapy

Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review.
Finelli R, Mottola F, Agarwal A
Int J Environ Res Public Health 2021 Dec 29;19(1) doi: 10.3390/ijerph19010328. PMID: 35010587Free PMC Article
Oestrogenic Endocrine Disruptors in the Placenta and the Fetus.
Tang ZR, Xu XL, Deng SL, Lian ZX, Yu K
Int J Mol Sci 2020 Feb 23;21(4) doi: 10.3390/ijms21041519. PMID: 32102189Free PMC Article
In utero exposure to carcinogens: Epigenetics, developmental disruption and consequences in later life.
Waring RH, Harris RM, Mitchell SC
Maturitas 2016 Apr;86:59-63. Epub 2016 Jan 19 doi: 10.1016/j.maturitas.2016.01.008. PMID: 26921930
Tobacco and pregnancy.
Rogers JM
Reprod Toxicol 2009 Sep;28(2):152-60. Epub 2009 Apr 9 doi: 10.1016/j.reprotox.2009.03.012. PMID: 19450949
Diethylstilbestrol exposure.
Schrager S, Potter BE
Am Fam Physician 2004 May 15;69(10):2395-400. PMID: 15168959

Prognosis

Birth defects in the sons and daughters of women who were exposed in utero to diethylstilbestrol (DES).
Titus-Ernstoff L, Troisi R, Hatch EE, Palmer JR, Hyer M, Kaufman R, Adam E, Noller K, Hoover RN
Int J Androl 2010 Apr;33(2):377-84. Epub 2009 Nov 30 doi: 10.1111/j.1365-2605.2009.01010.x. PMID: 20002218Free PMC Article
Ames, pesticides, and cancer revisited.
Richter ED, Chlamtac N
Int J Occup Environ Health 2002 Jan-Mar;8(1):63-72. doi: 10.1179/oeh.2002.8.1.63. PMID: 11843442
Occupational exposure to trace concentrations of waste anesthetic gases.
McGregor DG
Mayo Clin Proc 2000 Mar;75(3):273-7. doi: 10.4065/75.3.273. PMID: 10725954
Perinatal factors increase breast cancer risk.
Hilakivi-Clarke L, Clarke R, Lippman ME
Breast Cancer Res Treat 1994;31(2-3):273-84. doi: 10.1007/BF00666160. PMID: 7881105
The effects of exogenous female hormones on the fetus.
Shapiro S, Slone D
Epidemiol Rev 1979;1:110-23. doi: 10.1093/oxfordjournals.epirev.a036205. PMID: 398263

Clinical prediction guides

Prenatal exposure to diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development.
Rogers RE, Chai S, Pask AJ, Mattiske DM
Toxicol Sci 2023 Aug 29;195(1):53-60. doi: 10.1093/toxsci/kfad066. PMID: 37471692Free PMC Article
Are the Effects of DES Over? A Tragic Lesson from the Past.
Zamora-León P
Int J Environ Res Public Health 2021 Sep 30;18(19) doi: 10.3390/ijerph181910309. PMID: 34639609Free PMC Article
Are platinum nanoparticles safe to human health?
Czubacka E, Czerczak S
Med Pr 2019 Jul 16;70(4):487-495. Epub 2019 May 24 doi: 10.13075/mp.5893.00847. PMID: 31162484
Environmental signaling: from environmental estrogens to endocrine-disrupting chemicals and beyond.
McLachlan JA
Andrology 2016 Jul;4(4):684-94. Epub 2016 May 27 doi: 10.1111/andr.12206. PMID: 27230799
Nitrofen: a review and perspective.
Hurt SS, Smith JM, Hayes AW
Toxicology 1983 Dec;29(1-2):1-37. doi: 10.1016/0300-483x(83)90036-7. PMID: 6362073

Recent systematic reviews

Combined oestrogen and progesterone for preventing miscarriage.
Lim CE, Ho KK, Cheng NC, Wong FW
Cochrane Database Syst Rev 2013 Sep 25;2013(9):CD009278. doi: 10.1002/14651858.CD009278.pub2. PMID: 24068368Free PMC Article
Oestrogen supplementation, mainly diethylstilbestrol, for preventing miscarriages and other adverse pregnancy outcomes.
Bamigboye AA, Morris J
Cochrane Database Syst Rev 2003;2003(3):CD004353. doi: 10.1002/14651858.CD004353. PMID: 12918007Free PMC Article

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