Entry - %190310 - TREMOR, NYSTAGMUS, AND DUODENAL ULCER - OMIM

 
ICD+
% 190310

TREMOR, NYSTAGMUS, AND DUODENAL ULCER


Clinical Synopsis
 

Neuro
- Essential tremor
Misc
- Response to alcohol
- Cerebellar signs
- Nystagmus
GI
- Duodenal ulcer
Inheritance
- Autosomal dominant
▲ Close

TEXT

▼ Clinical Features

Neuhauser et al. (1976) described tremor, nystagmus, and duodenal ulcer in multiple persons in a kindred. Essential tremor developed in 12 of 17 affected members. Alcohol controlled the tremor temporarily. Severely affected members became alcoholics. The most severely affected persons showed cerebellar signs. Nystagmus occurred often in the absence of tremor and was usually congenital. Duodenal ulcer appeared to be a pleiotropic effect. It sometimes preceded onset of tremor.


▼ Inheritance

The transmission pattern of tremor, nystagums, and duodenal ulcer in the family reported by Neuhauser et al. (1976) was consistent with autosomal dominant inheritance.


▼ REFERENCES

  1. Neuhauser, G., Daly, R. R., Magnelli, N. C., Barreras, R. F., Donaldson, R. J., Jr., Opitz, J. M. Essential tremors, nystagmus and duodenal ulceration: a 'new' dominantly inherited condition. Clin. Genet. 9: 81-91, 1976. [PubMed: 1248168, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/2/1986
Edit History:
carol : 01/29/2016
carol : 8/13/2012
mgross : 3/18/2004
mimadm : 6/7/1995
supermim : 3/16/1992
carol : 3/2/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988

% 190310

TREMOR, NYSTAGMUS, AND DUODENAL ULCER


SNOMEDCT: 782935003;   ORPHA: 3350;  



TEXT

Clinical Features

Neuhauser et al. (1976) described tremor, nystagmus, and duodenal ulcer in multiple persons in a kindred. Essential tremor developed in 12 of 17 affected members. Alcohol controlled the tremor temporarily. Severely affected members became alcoholics. The most severely affected persons showed cerebellar signs. Nystagmus occurred often in the absence of tremor and was usually congenital. Duodenal ulcer appeared to be a pleiotropic effect. It sometimes preceded onset of tremor.


Inheritance

The transmission pattern of tremor, nystagums, and duodenal ulcer in the family reported by Neuhauser et al. (1976) was consistent with autosomal dominant inheritance.


REFERENCES

  1. Neuhauser, G., Daly, R. R., Magnelli, N. C., Barreras, R. F., Donaldson, R. J., Jr., Opitz, J. M. Essential tremors, nystagmus and duodenal ulceration: a 'new' dominantly inherited condition. Clin. Genet. 9: 81-91, 1976. [PubMed: 1248168] [Full Text: https://doi.org/10.1111/j.1399-0004.1976.tb01553.x]


Creation Date:
Victor A. McKusick : 6/2/1986

Edit History:
carol : 01/29/2016
carol : 8/13/2012
mgross : 3/18/2004
mimadm : 6/7/1995
supermim : 3/16/1992
carol : 3/2/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 8, 2024