In an Italian-American family with first-cousin parents, Greenberg et al. (1981) described 2 brothers, in a sibship of 5, who had this combination. In 1, colectomy with ileoproctostomy was performed for multiple adenomatous polyps of the colon at age 35. Because of multiple polyps and adenocarcinoma in situ in the residual rectum, abdominoperineal resection and ileostomy were done at age 40. Leukemia of acute myeloblastic type was discovered at age 45 and the patient died after a 2-month course. The second brother had fulguration of 2 papillary tumors of the bladder at age 25. In the next 3 years, he had multiple colonic polypectomies and abdominoperineal resection for Duke's stage C-1 carcinoma of the rectum. At age 34 he was discovered to have acute myeloblastic leukemia and died after a very short course.
Greenberg, M. S., Anderson, K. C., Marchetto, D. J., Li, F. P. Acute myelocytic leukemia in two brothers with polyposis coli and carcinoma of the colon. Ann. Intern. Med. 95: 702-703, 1981. [PubMed: 6946722] [Full Text: https://doi.org/10.7326/0003-4819-95-6-702]