Alternative titles; symbols
Cytogenetic location: 6p21.1-p12.2 Genomic coordinates (GRCh38): 6:40,500,001-53,000,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 6p21.1-p12.2 | {Migraine with or without aura, susceptibility to, 3} | 607498 | Autosomal dominant | 2 |
For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).
Carlsson et al. (2002) reported a large Swedish family with migraine with or without aura in 30 individuals spanning 4 generations. Clinical characteristics of both types included nausea and vomiting, photophobia, phonophobia, and long duration (greater than 12 hours).
By multipoint linkage analysis in a large Swedish family segregating migraine with or without aura, Carlsson et al. (2002) identified a maximum lod score of 5.78 at marker D6S452. Haplotype analysis restricted the disease locus to a 10-Mb region between flanking markers on chromosome 6p21.1-p12.2. The same migraine haplotype segregated in members with and without aura, suggesting that one or more genetic factors is involved in both migraine types in this family. Of 280 control chromosomes analyzed, none had the same allele as the disease haplotype.
Carlsson, A., Forsgren, L., Nylander, P.-O., Hellman, U., Forsman-Semb, K., Holmgren, G., Holmberg, D., Holmberg, M. Identification of a susceptibility locus for migraine with and without aura on 6p12.2-p21.1. Neurology 59: 1804-1807, 2002. [PubMed: 12473779] [Full Text: https://doi.org/10.1212/01.wnl.0000036617.04943.96]