Alternative titles; symbols
DO: 12783;
Cytogenetic location: 14q21.2-q22.3 Genomic coordinates (GRCh38): 14:43,000,001-57,600,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 14q21.2-q22.3 | {Migraine without aura, susceptibility to, 4} | 607501 | Autosomal dominant | 2 |
For a phenotypic description and discussion of genetic heterogeneity of migraine headaches, see MGR1 (157300).
Migraine is a complex and heterogeneous disorder characterized by recurrent attacks of headache associated with autonomic and neurologic symptoms. Two primary types of migraine can be distinguished: migraine without aura (MO) and migraine with aura.
Soragna et al. (2003) studied a large 4-generation Italian family, originating from a restricted geographic area of northern Italy, in which migraine without aura appeared to segregate as an autosomal dominant trait. They excluded association between MO in this family and previously identified migraine loci, including the migraine with aura susceptibility locus on chromosome 4q24 (157300). Using a genomewide scan, they obtained significant evidence of linkage between the MO phenotype and marker D14S978 on 14q22.1 (maximum 2-point lod score of 3.70 at a recombination fraction of 0.01). Multipoint parametric analysis (maximum lod score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a 10-cM region flanked by markers D14S1027 and D14S980 on 14q21.2-q22.3.
Soragna, D., Vettori, A., Carraro, G., Marchioni, E., Vazza, G., Bellini, S., Tupler, R., Savoldi, F., Mostacciuolo, M. L. A locus for migraine without aura maps on chromosome 14q21.2-q22.3. Am. J. Hum. Genet. 72: 161-167, 2003. [PubMed: 12474141] [Full Text: https://doi.org/10.1086/345298]