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cyfip2 cytoplasmic FMR1 interacting protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 100002872, updated on 27-Mar-2024

Summary

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Official Symbol
cyfip2provided by ZNC
Official Full Name
cytoplasmic FMR1 interacting protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080724-2
See related
Ensembl:ENSDARG00000036375 AllianceGenome:ZFIN:ZDB-GENE-080724-2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:194528
Summary
Acts upstream of or within with a positive effect on retinal ganglion cell axon guidance. Acts upstream of or within retina layer formation and startle response. Predicted to be located in cytoplasm. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 65. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33983346..34044426, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (33643035..33704112, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene sarcoplasmic reticulum histidine-rich calcium-binding protein-like Neighboring gene forkhead box A sequence Neighboring gene IL2 inducible T cell kinase Neighboring gene mediator complex subunit 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold. Marsden KC, et al. Cell Rep, 2018 Apr 17. PMID 29669291, Free PMC Article
  2. Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function. Cioni JM, et al. Neuron, 2018 Mar 7. PMID 29518358, Free PMC Article
  3. nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system. Pittman AJ, et al. Dev Biol, 2010 Aug 15. PMID 20537992, Free PMC Article
  4. Genetic dissection of the retinotectal projection. Baier H, et al. Development, 1996 Dec. PMID 9007259
  5. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cyfip2 regulates the innate startle threshold by reducing neural activity in a small group of excitatory hindbrain interneurons.
    Title: A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold.
  2. CYFIP2's function in axon sorting is mediated by its binding to the WAVE regulatory complex, but not its translational regulation.
    Title: Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function.
  3. cyfip2 is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
    Title: nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina layer formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic FMR1-interacting protein 2
Names
nev
nevermind

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097587.1 → NP_001091056.1  cytoplasmic FMR1-interacting protein 2

    See identical proteins and their annotated locations for NP_001091056.1

    Status: PROVISIONAL

    Source sequence(s)
    EF531617
    UniProtKB/TrEMBL
    A0A8M1NEL2, A5A5E1
    Conserved Domains (2) summary
    pfam05994
    Location:387 → 1221
    FragX_IP; Cytoplasmic Fragile-X interacting family
    pfam07159
    Location:65 → 267
    DUF1394; Protein of unknown function (DUF1394)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    33983346..34044426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009291081.3 → XP_009289356.1  cytoplasmic FMR1-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AS06
    Related
    ENSDARP00000147949.1, ENSDART00000190746.1
    Conserved Domains (2) summary
    pfam05994
    Location:385 → 1219
    FragX_IP; Cytoplasmic Fragile-X interacting family
    pfam07159
    Location:65 → 267
    DUF1394; Protein of unknown function (DUF1394)

  2. XM_009291080.3 → XP_009289355.1  cytoplasmic FMR1-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_009289355.1

    UniProtKB/TrEMBL
    A0A8M3AHW5, B3DIT1
    Related
    ENSDARP00000124883.2, ENSDART00000149396.5
    Conserved Domains (2) summary
    pfam05994
    Location:387 → 1220
    FragX_IP; Cytoplasmic Fragile-X interacting family
    pfam07159
    Location:65 → 267
    DUF1394; Protein of unknown function (DUF1394)

  3. XM_009291082.3 → XP_009289357.1  cytoplasmic FMR1-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AP56
    Conserved Domains (2) summary
    pfam05994
    Location:387 → 1015
    FragX_IP; Cytoplasmic Fragile-X interacting family
    pfam07159
    Location:65 → 267
    DUF1394; Protein of unknown function (DUF1394)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394918.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    155819..207189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395316.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    161286..216122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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