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ripk3 receptor-interacting serine-threonine kinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 100004555, updated on 11-Apr-2024

Summary

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Official Symbol
ripk3provided by ZNC
Official Full Name
receptor-interacting serine-threonine kinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-071115-4
See related
AllianceGenome:ZFIN:ZDB-GENE-071115-4
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ripk3l
Summary
Predicted to enable protein kinase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human RIPK3 (receptor interacting serine/threonine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 7
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (1323440..1366221, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (1169801..1211343, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene macrophage mannose receptor 1-like Neighboring gene si:dkeyp-74b6.2 Neighboring gene KH and NYN domain containing Neighboring gene solute carrier family 12 member 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RIPK3 collaborates with RIPK1 to inhibit MAVS-mediated signaling during black carp antiviral innate immunity. Dai Y, et al. Fish Shellfish Immunol, 2021 Aug. PMID 34147612
  2. Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport. Roca FJ, et al. Science, 2022 Jun 24. PMID 35737799, Free PMC Article
  3. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Roca FJ, et al. Cell, 2013 Apr 25. PMID 23582643, Free PMC Article
  4. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Roca FJ, et al. Cell, 2019 Sep 5. PMID 31474371, Free PMC Article
  5. Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. Yu T, et al. J Biol Chem, 2020 Jun 26. PMID 32398256, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
receptor-interacting serine/threonine-protein kinase 3
Names
receptor-interacting serine-threonine kinase 3 like
XP_001343827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    1323440..1366221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001343791.5 → XP_001343827.1  receptor-interacting serine/threonine-protein kinase 3

    UniProtKB/TrEMBL
    A0A8M1PSS7
    Conserved Domains (2) summary
    smart00219
    Location:20 → 287
    TyrKc; Tyrosine kinase, catalytic domain
    cl21453
    Location:24 → 285
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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