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Apc APC, WNT signaling pathway regulator [ Mus musculus (house mouse) ]

Gene ID: 11789, updated on 21-Apr-2024

Summary

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Official Symbol
Apcprovided by MGI
Official Full Name
APC, WNT signaling pathway regulatorprovided by MGI
Primary source
MGI:MGI:88039
See related
Ensembl:ENSMUSG00000005871 AllianceGenome:MGI:88039
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CC1; Min; mAPC
Summary
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and enzyme binding activity. Involved in insulin receptor signaling pathway; positive regulation of cold-induced thermogenesis; and positive regulation of protein localization to centrosome. Acts upstream of or within several processes, including animal organ development; regionalization; and regulation of microtubule polymerization or depolymerization. Located in several cellular components, including axonal growth cone; cell projection membrane; and microtubule cytoskeleton. Part of Scrib-APC-beta-catenin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and retina. Used to study breast cancer; familial adenomatous polyposis; gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 29.9), CNS E18 (RPKM 22.5) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.53 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34353350..34455243)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34220297..34322190)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41686 Neighboring gene predicted gene, 23411 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34380446-34380555 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44199 Neighboring gene predicted gene, 54017 Neighboring gene signal recognition particle 19 Neighboring gene receptor accessory protein 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lentiviral in situ targeting of stem cells in unperturbed intestinal epithelium. Garside GB, et al. BMC Biol, 2023 Jan 11. PMID 36627630, Free PMC Article
  2. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells. Kitchen-Goosen SM, et al. Carcinogenesis, 2023 May 15. PMID 36548952, Free PMC Article
  3. Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients. Zhao L, et al. Oncogene, 2022 Sep. PMID 35882981, Free PMC Article
  4. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Sebastian C, et al. Nat Commun, 2022 Mar 21. PMID 35314684, Free PMC Article
  5. Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer. Sougiannis AT, et al. Am J Physiol Gastrointest Liver Physiol, 2022 Mar 1. PMID 35018819, Free PMC Article

See all (1782) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
    Title: Endothelial Protein C Receptor and 3K3A-Activated Protein C Protect Mice from Allergic Contact Dermatitis in a Contact Hypersensitivity Model.
  2. Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
    Title: Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth.
  3. Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
    Title: Inactivation of the tumor suppressor gene Apc synergizes with H. pylori to induce DNA damage in murine gastric stem and progenitor cells.
  4. Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
    Title: Role of Reduced Bdnf Expression in Novel Apc Mutant Allele-induced Intestinal and Colonic Tumorigenesis in Mice.
  5. Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
    Title: Endometrial hyperplasia with loss of APC in a novel population of Lyz2-expressing mouse endometrial epithelial cells.
  6. LAT1 expression influences Paneth cell number and tumor development in Apc[Min/+] mice.
    Title: LAT1 expression influences Paneth cell number and tumor development in Apc(Min/+) mice.
  7. Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
    Title: Rare Genetic Variants in Human APC Are Implicated in Mesiodens and Isolated Supernumerary Teeth.
  8. USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
    Title: USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development.
  9. HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
    Title: HER2 and APC Mutations Promote Altered Crypt-Villus Morphology and Marked Hyperplasia in the Intestinal Epithelium.
  10. Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
    Title: Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer.
Submit: New GeneRIF Correction See all GeneRIFs (229)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (27)  1 citation
  • Chemically induced (ENU) (2)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
  
enables gamma-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule plus-end binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule plus-end binding ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of acinar cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of acinar cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within axonogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway involved in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway involved in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chromosome organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cytoplasmic microtubule organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment or maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle cell cellular homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of acinar cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of acinar cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of odontogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of odontogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of pseudopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of attachment of spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of nitrogen compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of Scrib-APC-beta-catenin complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonal growth cone ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin destruction complex ISO
Inferred from Sequence Orthology
more info
  
part_of beta-catenin destruction complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenomatous polyposis coli protein
Names
adenomatosis polyposis coli
multiple intestinal neoplasia

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360979.1 → NP_001347908.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:588 → 628
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:404 → 447
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:630 → 668
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1576 → 1599
    APC_r; APC repeat
    pfam05924
    Location:1973 → 1992
    SAMP; SAMP Motif
    pfam05937
    Location:2611 → 2783
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2164 → 2509
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:671 → 958
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:975 → 1074
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1222 → 1308
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1601 → 1654
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1685 → 1778
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1812 → 1886
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  2. NM_001360980.1 → NP_001347909.1  adenomatous polyposis coli protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (16) summary
    smart00185
    Location:665 → 705
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:579 → 611
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:707 → 745
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1653 → 1676
    APC_r; APC repeat
    pfam05924
    Location:2050 → 2069
    SAMP; SAMP Motif
    pfam05937
    Location:2688 → 2860
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2241 → 2586
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:748 → 1035
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1052 → 1151
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1299 → 1385
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1678 → 1731
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1762 → 1855
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1889 → 1963
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:391 → 464
    APC_rep; Adenomatous polyposis coli (APC) repeat

  3. NM_001402727.1 → NP_001389656.1  adenomatous polyposis coli protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  4. NM_001402728.1 → NP_001389657.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  5. NM_001402729.1 → NP_001389658.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  6. NM_001402730.1 → NP_001389659.1  adenomatous polyposis coli protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  7. NM_001402731.1 → NP_001389660.1  adenomatous polyposis coli protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    UniProtKB/TrEMBL
    B2RUG9

  8. NM_001402732.1 → NP_001389661.1  adenomatous polyposis coli protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  9. NM_001402733.1 → NP_001389662.1  adenomatous polyposis coli protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  10. NM_001402734.1 → NP_001389663.1  adenomatous polyposis coli protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  11. NM_001402735.1 → NP_001389664.1  adenomatous polyposis coli protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  12. NM_001402736.1 → NP_001389665.1  adenomatous polyposis coli protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  13. NM_001402737.1 → NP_001389666.1  adenomatous polyposis coli protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  14. NM_001402738.1 → NP_001389667.1  adenomatous polyposis coli protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  15. NM_001402739.1 → NP_001389668.1  adenomatous polyposis coli protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373
    Related
    ENSMUSP00000111447.4, ENSMUST00000115781.10

  16. NM_001402740.1 → NP_001389669.1  adenomatous polyposis coli protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC090534, AC114003, AL591373

  17. NM_007462.4 → NP_031488.2  adenomatous polyposis coli protein isoform 3

    See identical proteins and their annotated locations for NP_031488.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC090534, AC114003, AL591373
    Consensus CDS
    CCDS29125.1
    UniProtKB/Swiss-Prot
    Q61315, Q62044
    UniProtKB/TrEMBL
    B2RUG9
    Related
    ENSMUSP00000078337.6, ENSMUST00000079362.13
    Conserved Domains (16) summary
    smart00185
    Location:647 → 687
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:463 → 506
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:689 → 727
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1635 → 1658
    APC_r; APC repeat
    pfam05924
    Location:2032 → 2051
    SAMP; SAMP Motif
    pfam05937
    Location:2670 → 2842
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2223 → 2568
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:730 → 1017
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1034 → 1133
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1281 → 1367
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1660 → 1713
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1744 → 1837
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1871 → 1945
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:391 → 464
    APC_rep; Adenomatous polyposis coli (APC) repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34353350..34455243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525529.4 → XP_006525592.1  adenomatous polyposis coli protein isoform X1

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:675 → 715
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:589 → 621
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:717 → 755
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1663 → 1686
    APC_r; APC repeat
    pfam05924
    Location:2060 → 2079
    SAMP; SAMP Motif
    pfam05937
    Location:2698 → 2870
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2251 → 2596
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:758 → 1045
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1062 → 1161
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1309 → 1395
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1688 → 1741
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1772 → 1865
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1899 → 1973
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:401 → 474
    APC_rep; Adenomatous polyposis coli (APC) repeat

  2. XM_006525538.4 → XP_006525601.1  adenomatous polyposis coli protein isoform X15

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:574 → 614
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:488 → 520
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:616 → 654
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1562 → 1585
    APC_r; APC repeat
    pfam05924
    Location:1959 → 1978
    SAMP; SAMP Motif
    pfam05937
    Location:2597 → 2769
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2150 → 2495
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:657 → 944
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:961 → 1060
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1208 → 1294
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1587 → 1640
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1671 → 1764
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1798 → 1872
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:315 → 373
    APC_rep; Adenomatous polyposis coli (APC) repeat

  3. XM_006525534.4 → XP_006525597.1  adenomatous polyposis coli protein isoform X6

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:640 → 680
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:554 → 586
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:682 → 720
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1628 → 1651
    APC_r; APC repeat
    pfam05924
    Location:2025 → 2044
    SAMP; SAMP Motif
    pfam05937
    Location:2663 → 2835
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2216 → 2561
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:723 → 1010
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1027 → 1126
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1274 → 1360
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1653 → 1706
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1737 → 1830
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1864 → 1938
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:366 → 439
    APC_rep; Adenomatous polyposis coli (APC) repeat

  4. XM_036160948.1 → XP_036016841.1  adenomatous polyposis coli protein isoform X21

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:539 → 579
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:453 → 485
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:581 → 621
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1527 → 1550
    APC_r; APC repeat
    pfam05924
    Location:1924 → 1943
    SAMP; SAMP Motif
    pfam05937
    Location:2562 → 2734
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2115 → 2460
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:622 → 909
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:926 → 1025
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1173 → 1259
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1552 → 1605
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1636 → 1729
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1763 → 1837
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:280 → 338
    APC_rep; Adenomatous polyposis coli (APC) repeat

  5. XM_036160950.1 → XP_036016843.1  adenomatous polyposis coli protein isoform X24

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:521 → 561
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:337 → 380
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:563 → 603
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1509 → 1532
    APC_r; APC repeat
    pfam05924
    Location:1906 → 1925
    SAMP; SAMP Motif
    pfam05937
    Location:2544 → 2716
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2097 → 2442
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:604 → 891
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:908 → 1007
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1155 → 1241
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1534 → 1587
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1618 → 1711
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1745 → 1819
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:280 → 338
    APC_rep; Adenomatous polyposis coli (APC) repeat

  6. XM_030250280.1 → XP_030106140.1  adenomatous polyposis coli protein isoform X9

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:622 → 662
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:438 → 481
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:664 → 702
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1610 → 1633
    APC_r; APC repeat
    pfam05924
    Location:2007 → 2026
    SAMP; SAMP Motif
    pfam05937
    Location:2645 → 2817
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2198 → 2543
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:705 → 992
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1009 → 1108
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1256 → 1342
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1635 → 1688
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1719 → 1812
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1846 → 1920
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:366 → 439
    APC_rep; Adenomatous polyposis coli (APC) repeat

  7. XM_036160951.1 → XP_036016844.1  adenomatous polyposis coli protein isoform X25

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:511 → 551
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:327 → 370
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:553 → 593
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1499 → 1522
    APC_r; APC repeat
    pfam05924
    Location:1896 → 1915
    SAMP; SAMP Motif
    pfam05937
    Location:2534 → 2706
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2087 → 2432
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:594 → 881
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:898 → 997
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1145 → 1231
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1524 → 1577
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1608 → 1701
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1735 → 1809
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:270 → 328
    APC_rep; Adenomatous polyposis coli (APC) repeat

  8. XM_006525539.4 → XP_006525602.1  adenomatous polyposis coli protein isoform X20

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (16) summary
    smart00185
    Location:546 → 586
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:362 → 405
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:588 → 628
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1534 → 1557
    APC_r; APC repeat
    pfam05924
    Location:1931 → 1950
    SAMP; SAMP Motif
    pfam05937
    Location:2569 → 2741
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2122 → 2467
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:629 → 916
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:933 → 1032
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1180 → 1266
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1559 → 1612
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1643 → 1736
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1770 → 1844
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:305 → 363
    APC_rep; Adenomatous polyposis coli (APC) repeat

  9. XM_030250281.2 → XP_030106141.1  adenomatous polyposis coli protein isoform X10

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:612 → 652
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:428 → 471
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:654 → 694
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1600 → 1623
    APC_r; APC repeat
    pfam05924
    Location:1997 → 2016
    SAMP; SAMP Motif
    pfam05937
    Location:2635 → 2807
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2188 → 2533
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:695 → 982
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:999 → 1098
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1246 → 1332
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1625 → 1678
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1709 → 1802
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1836 → 1910
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:356 → 429
    APC_rep; Adenomatous polyposis coli (APC) repeat

  10. XM_030250288.1 → XP_030106148.1  adenomatous polyposis coli protein isoform X16

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:571 → 611
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:485 → 517
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:613 → 651
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1559 → 1582
    APC_r; APC repeat
    pfam05924
    Location:1956 → 1975
    SAMP; SAMP Motif
    pfam05937
    Location:2594 → 2766
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2147 → 2492
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:654 → 941
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:958 → 1057
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1205 → 1291
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1584 → 1637
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1668 → 1761
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1795 → 1869
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297 → 370
    APC_rep; Adenomatous polyposis coli (APC) repeat

  11. XM_030250283.1 → XP_030106143.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606 → 646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520 → 552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648 → 688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1594 → 1617
    APC_r; APC repeat
    pfam05924
    Location:1991 → 2010
    SAMP; SAMP Motif
    pfam05937
    Location:2629 → 2801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2182 → 2527
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689 → 976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:993 → 1092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1240 → 1326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1619 → 1672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1703 → 1796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1830 → 1904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  12. XM_036160952.1 → XP_036016845.1  adenomatous polyposis coli protein isoform X26

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:487 → 527
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:303 → 346
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:529 → 569
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1475 → 1498
    APC_r; APC repeat
    pfam05924
    Location:1872 → 1891
    SAMP; SAMP Motif
    pfam05937
    Location:2510 → 2682
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2063 → 2408
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:570 → 857
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:874 → 973
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1121 → 1207
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1500 → 1553
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1584 → 1677
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1711 → 1785
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:246 → 304
    APC_rep; Adenomatous polyposis coli (APC) repeat

  13. XM_030250278.2 → XP_030106138.1  adenomatous polyposis coli protein isoform X7

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (16) summary
    smart00185
    Location:630 → 670
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:544 → 576
    ARM; armadillo repeat [structural motif]
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam00514
    Location:672 → 712
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1618 → 1641
    APC_r; APC repeat
    pfam05924
    Location:2015 → 2034
    SAMP; SAMP Motif
    pfam05937
    Location:2653 → 2825
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2206 → 2551
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:713 → 1000
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1017 → 1116
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1264 → 1350
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1643 → 1696
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1727 → 1820
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1854 → 1928
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:356 → 429
    APC_rep; Adenomatous polyposis coli (APC) repeat

  14. XM_030250291.1 → XP_030106151.1  adenomatous polyposis coli protein isoform X18

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:556 → 596
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:372 → 415
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:598 → 636
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1544 → 1567
    APC_r; APC repeat
    pfam05924
    Location:1941 → 1960
    SAMP; SAMP Motif
    pfam05937
    Location:2579 → 2751
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2132 → 2477
    APC_basic; APC basic domain
    pfam11414
    Location:135 → 215
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:639 → 926
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:943 → 1042
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1190 → 1276
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1569 → 1622
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1653 → 1746
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1780 → 1854
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:315 → 373
    APC_rep; Adenomatous polyposis coli (APC) repeat

  15. XM_036160946.1 → XP_036016839.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606 → 646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520 → 552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648 → 688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1594 → 1617
    APC_r; APC repeat
    pfam05924
    Location:1991 → 2010
    SAMP; SAMP Motif
    pfam05937
    Location:2629 → 2801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2182 → 2527
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689 → 976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:993 → 1092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1240 → 1326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1619 → 1672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1703 → 1796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1830 → 1904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  16. XM_030250293.2 → XP_030106153.1  adenomatous polyposis coli protein isoform X22

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (17) summary
    smart00185
    Location:529 → 569
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:443 → 475
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:571 → 609
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1517 → 1540
    APC_r; APC repeat
    pfam05924
    Location:1914 → 1933
    SAMP; SAMP Motif
    pfam05937
    Location:2552 → 2724
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2105 → 2450
    APC_basic; APC basic domain
    pfam11414
    Location:125 → 205
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:612 → 899
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:916 → 1015
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1163 → 1249
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1542 → 1595
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1626 → 1719
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1753 → 1827
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam16689
    Location:4 → 55
    APC_N_CC; Coiled-coil N-terminus of APC, dimerization domain
    pfam18797
    Location:270 → 328
    APC_rep; Adenomatous polyposis coli (APC) repeat
    cl00755
    Location:172 → 296
    zf-dskA_traR; Prokaryotic dksA/traR C4-type zinc finger

  17. XM_030250282.2 → XP_030106142.1  adenomatous polyposis coli protein isoform X11

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:610 → 650
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:524 → 556
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:652 → 690
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1598 → 1621
    APC_r; APC repeat
    pfam05924
    Location:1995 → 2014
    SAMP; SAMP Motif
    pfam05937
    Location:2633 → 2805
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2186 → 2531
    APC_basic; APC basic domain
    pfam11414
    Location:105 → 185
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:693 → 980
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:997 → 1096
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1244 → 1330
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1623 → 1676
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1707 → 1800
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1834 → 1908
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:336 → 409
    APC_rep; Adenomatous polyposis coli (APC) repeat

  18. XM_006525533.4 → XP_006525596.1  adenomatous polyposis coli protein isoform X5

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:645 → 685
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:559 → 591
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:687 → 725
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1633 → 1656
    APC_r; APC repeat
    pfam05924
    Location:2030 → 2049
    SAMP; SAMP Motif
    pfam05937
    Location:2668 → 2840
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2221 → 2566
    APC_basic; APC basic domain
    pfam11414
    Location:105 → 185
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:728 → 1015
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:1032 → 1131
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1279 → 1365
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1658 → 1711
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1742 → 1835
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1869 → 1943
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:371 → 444
    APC_rep; Adenomatous polyposis coli (APC) repeat

  19. XM_030250289.2 → XP_030106149.1  adenomatous polyposis coli protein isoform X16

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:571 → 611
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:485 → 517
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:613 → 651
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1559 → 1582
    APC_r; APC repeat
    pfam05924
    Location:1956 → 1975
    SAMP; SAMP Motif
    pfam05937
    Location:2594 → 2766
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2147 → 2492
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:654 → 941
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:958 → 1057
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1205 → 1291
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1584 → 1637
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1668 → 1761
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1795 → 1869
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297 → 370
    APC_rep; Adenomatous polyposis coli (APC) repeat

  20. XM_006525536.5 → XP_006525599.1  adenomatous polyposis coli protein isoform X12

    See identical proteins and their annotated locations for XP_006525599.1

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606 → 646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520 → 552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648 → 688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1594 → 1617
    APC_r; APC repeat
    pfam05924
    Location:1991 → 2010
    SAMP; SAMP Motif
    pfam05937
    Location:2629 → 2801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2182 → 2527
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689 → 976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:993 → 1092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1240 → 1326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1619 → 1672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1703 → 1796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1830 → 1904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  21. XM_030250292.2 → XP_030106152.1  adenomatous polyposis coli protein isoform X19

    UniProtKB/TrEMBL
    E9QLQ9
    Conserved Domains (15) summary
    smart00185
    Location:553 → 593
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:369 → 412
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:595 → 633
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1541 → 1564
    APC_r; APC repeat
    pfam05924
    Location:1938 → 1957
    SAMP; SAMP Motif
    pfam05937
    Location:2576 → 2748
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2129 → 2474
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:636 → 923
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:940 → 1039
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1187 → 1273
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1566 → 1619
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1650 → 1743
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1777 → 1851
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:297 → 370
    APC_rep; Adenomatous polyposis coli (APC) repeat

  22. XM_030250284.2 → XP_030106144.1  adenomatous polyposis coli protein isoform X12

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:606 → 646
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:520 → 552
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:648 → 688
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1594 → 1617
    APC_r; APC repeat
    pfam05924
    Location:1991 → 2010
    SAMP; SAMP Motif
    pfam05937
    Location:2629 → 2801
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2182 → 2527
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:689 → 976
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:993 → 1092
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1240 → 1326
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1619 → 1672
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1703 → 1796
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1830 → 1904
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:332 → 405
    APC_rep; Adenomatous polyposis coli (APC) repeat

  23. XM_030250295.2 → XP_030106155.1  adenomatous polyposis coli protein isoform X26

    UniProtKB/Swiss-Prot
    Q61315, Q62044
    Conserved Domains (15) summary
    smart00185
    Location:487 → 527
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:303 → 346
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:529 → 569
    Arm; Armadillo/beta-catenin-like repeat
    pfam05923
    Location:1475 → 1498
    APC_r; APC repeat
    pfam05924
    Location:1872 → 1891
    SAMP; SAMP Motif
    pfam05937
    Location:2510 → 2682
    EB1_binding; EB-1 Binding Domain
    pfam05956
    Location:2063 → 2408
    APC_basic; APC basic domain
    pfam11414
    Location:66 → 146
    Suppressor_APC; Adenomatous polyposis coli tumor suppressor protein
    pfam16629
    Location:570 → 857
    Arm_APC_u3; Armadillo-associated region on APC
    pfam16630
    Location:874 → 973
    APC_u5; Unstructured region on APC between 1st and 2nd catenin-bdg motifs
    pfam16633
    Location:1121 → 1207
    APC_u9; Unstructured region on APC between 1st two creatine-rich regions
    pfam16634
    Location:1500 → 1553
    APC_u13; Unstructured region on APC between APC_crr and SAMP
    pfam16635
    Location:1584 → 1677
    APC_u14; Unstructured region on APC between SAMP and APC_crr
    pfam16636
    Location:1711 → 1785
    APC_u15; Unstructured region on APC between APC_crr regions 5 and 6
    pfam18797
    Location:246 → 304
    APC_rep; Adenomatous polyposis coli (APC) repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61315.1 GenPept UniProtKB/Swiss-Prot:Q61315

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