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Chrm1 cholinergic receptor, muscarinic 1, CNS [ Mus musculus (house mouse) ]

Gene ID: 12669, updated on 21-Apr-2024

Summary

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Official Symbol
Chrm1provided by MGI
Official Full Name
cholinergic receptor, muscarinic 1, CNSprovided by MGI
Primary source
MGI:MGI:88396
See related
Ensembl:ENSMUSG00000032773 AllianceGenome:MGI:88396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
M1; M1R; Chrm-1
Summary
Enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Located in cholinergic synapse. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic membrane. Is expressed in central nervous system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 19.3), frontal lobe adult (RPKM 14.8) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.44 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8641369..8660970)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8664005..8683606)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36394 Neighboring gene solute carrier family 22 (organic anion transporter), member 6 Neighboring gene RIKEN cDNA 9830166K06 gene Neighboring gene STARR-positive B cell enhancer ABC_E8737 Neighboring gene STARR-positive B cell enhancer ABC_E9454 Neighboring gene solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1210 Neighboring gene predicted gene, 25855 Neighboring gene small nucleolar RNA host gene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M(1) Muscarinic Receptor. Li WP, et al. Biol Psychiatry, 2022 Dec 15. PMID 35787318
  2. The M(1) muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Marsango S, et al. Proc Natl Acad Sci U S A, 2022 Jun 14. PMID 35671422, Free PMC Article
  3. M(1) Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder. Maksymetz J, et al. Biol Psychiatry, 2019 Jun 15. PMID 31003787, Free PMC Article
  4. Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex. Oda S, et al. J Comp Neurol, 2018 Jun 1. PMID 29424434, Free PMC Article
  5. Broad analgesic activity of a novel, selective M1 agonist. Wood MW, et al. Neuropharmacology, 2017 Sep 1. PMID 28623171

See all (170) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease.
    Title: Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer's Disease.
  2. The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
    Title: The M1 muscarinic acetylcholine receptor regulates the surface expression of the AMPA receptor subunit GluA2 via PICK1.
  3. Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M1 Muscarinic Receptor.
    Title: Astrocytes Mediate Cholinergic Regulation of Adult Hippocampal Neurogenesis and Memory Through M(1) Muscarinic Receptor.
  4. Hippocampal knockdown of alpha2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
    Title: Hippocampal knockdown of α2 nicotinic or M1 muscarinic acetylcholine receptors in C57BL/6J male mice impairs cued fear conditioning.
  5. PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit.
    Title: PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit.
  6. Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
    Title: Diverse glutamatergic inputs target spines expressing M1 muscarinic receptors in the basolateral amygdala: An ultrastructural analysis.
  7. The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.
    Title: The M(1) muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.
  8. Biased M1 receptor-positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity.
    Title: Biased M(1) receptor-positive allosteric modulators reveal role of phospholipase D in M(1)-dependent rodent cortical plasticity.
  9. M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex. M1 mAChRs dynamically modulate synaptic transmission at two prefrontal cortex inputs whose activity is necessary for fear extinction, and M1 mAChR function is required for proper contextual fear extinction.
    Title: M(1) Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder.
  10. Chrm1 and Chrm3 double knockout chronically diminishes REM sleep to an almost undetectable level. These results suggest that muscarinic acetylcholine receptors, Chrm1 and Chrm3, are essential for REM sleep.
    Title: Muscarinic Acetylcholine Receptors Chrm1 and Chrm3 Are Essential for REM Sleep.
Submit: New GeneRIF Correction See all GeneRIFs (63)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled acetylcholine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of monoatomic ion transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission EXP
Inferred from Experiment
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cholinergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
muscarinic acetylcholine receptor M1
Names
AChR M1
m1 muscarinic acetylcholine receptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112697.1 → NP_001106167.1  muscarinic acetylcholine receptor M1

    See identical proteins and their annotated locations for NP_001106167.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC025794, AK138282, AW495047, BB848456, BC094242, BY062993
    Consensus CDS
    CCDS29539.1
    UniProtKB/Swiss-Prot
    P12657, Q52KQ0, Q8BJN3
    Related
    ENSMUSP00000126103.2, ENSMUST00000163785.2
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_007698.3 → NP_031724.2  muscarinic acetylcholine receptor M1

    See identical proteins and their annotated locations for NP_031724.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC025794, AK138282, AW495047, BC094242
    Consensus CDS
    CCDS29539.1
    UniProtKB/Swiss-Prot
    P12657, Q52KQ0, Q8BJN3
    Related
    ENSMUSP00000042632.4, ENSMUST00000035444.10
    Conserved Domains (1) summary
    cd17790
    Location:26 → 429
    7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8641369..8660970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12657.2 GenPept UniProtKB/Swiss-Prot:P12657

Gene LinkOut

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