Il9r interleukin 9 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il9rprovided by MGI
Official Full Name: interleukin 9 receptorprovided by MGI
Primary source: MGI:MGI:96564
See related: Ensembl:ENSMUSG00000020279 AllianceGenome:MGI:96564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables interleukin-9 receptor activity. Acts upstream of or within B cell activation; immunoglobulin mediated immune response; and regulation of cellular protein metabolic process. Located in cell surface and plasma membrane. Is expressed in bone marrow. Orthologous to human IL9R (interleukin 9 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 4.9), thymus adult (RPKM 1.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 18.82 cM; 11 A4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (32137544..32155283, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (32187544..32205283, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
Title: Upregulated Expression of the IL-9 Receptor on TRAF3-Deficient B Lymphocytes Confers Ig Isotype Switching Responsiveness to IL-9 in the Presence of Antigen Receptor Engagement and IL-4.
IL-9 stimulates an anti-tumor immune response and facilitates immune checkpoint blockade in the CMT167 mouse model.
Title: IL-9 stimulates an anti-tumor immune response and facilitates immune checkpoint blockade in the CMT167 mouse model.
Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage.
Title: Expression Efficiency of Multiple Il9 Reporter Alleles Is Determined by Cell Lineage.
this study shows that more severe EAE in IL-9R-/- mice correlates with increased numbers of GM-CSF+ CD4+ T cells
Title: IL-9 Controls Central Nervous System Autoimmunity by Suppressing GM-CSF Production.
this paper shows that IL-9 receptor signaling in memory B cells regulates humoral recall responses
Title: IL-9 receptor signaling in memory B cells regulates humoral recall responses.
Mice with PU.1 deficiency in T cells were protected from colitis, whereas treatment with antibody to IL-9 suppressed colitis
Title: TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells.
Data indicate that increased expression of interleukin-9 receptor (Il9R) is associated with an increased binding of nucleolin.
Title: Interleukin-9 receptor gene is transcriptionally regulated by nucleolin in T-cell lymphoma cells.
IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants.
Title: Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers.
These data suggest that IL-9/IL-9 receptor signaling pathway represents a novel endogenous antiapoptotic mechanism for cortical neurons by controlling JAK/STAT and Bax levels.
Title: IL-9/IL-9 receptor signaling selectively protects cortical neurons against developmental apoptosis.
These results suggest that the unusual expression of interleukin-9 receptors and/or increased responsiveness of thymocytes to cytokines are key processes in the development of radiation-induced T cell lymphomas.
Title: Elevated interleukin-9 receptor expression and response to interleukins-9 and -7 in thymocytes during radiation-induced T-cell lymphomagenesis in B6C3F1 mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

General gene information

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Markers

M84746 (e-PCR)
- UniSTS:124994

Il9r (e-PCR), detects polymorphism
- UniSTS:259186

NoName (e-PCR)
- UniSTS:489076

M84746 (e-PCR)
- UniSTS:180171

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-9 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-9 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-9 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-9 receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables interleukin-9 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within interleukin-9-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-9 receptor

Names: IL-9 receptor; IL-9R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134458.1 → NP_001127930.1 interleukin-9 receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_001127930.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes a protein isoform (1) that is shorter by 1 amino acid due to use of an alternate splice acceptor site.

Source sequence(s)

AL929446

Consensus CDS

CCDS48765.1

UniProtKB/TrEMBL

A2AVE0, B7ZD65

Related

ENSMUSP00000119557.2, ENSMUST00000128311.8

Conserved Domains (1) summary

cd00063
Location:147 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_008374.2 → NP_032400.1 interleukin-9 receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_032400.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes a protein isoform (2) that is longer by 1 amino acid due to use of an alternate splice acceptor site.

Source sequence(s)

AL929446

Consensus CDS

CCDS24517.1

UniProtKB/Swiss-Prot

Q01114

UniProtKB/TrEMBL

B7ZD65, Q78PA5

Related

ENSMUSP00000118204.2, ENSMUST00000145401.8

Conserved Domains (1) summary

cd00063
Location:147 → 253

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

32137544..32155283 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514539.3 → XP_006514602.1 interleukin-9 receptor isoform X6

See identical proteins and their annotated locations for XP_006514602.1

UniProtKB/TrEMBL

A2AVE0, B7ZD65

Conserved Domains (1) summary

cd00063
Location:147 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017314298.2 → XP_017169787.1 interleukin-9 receptor isoform X4

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:195 → 301

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006514537.3 → XP_006514600.1 interleukin-9 receptor isoform X3

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:195 → 302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006514538.4 → XP_006514601.1 interleukin-9 receptor isoform X5

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:157 → 264

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006514540.4 → XP_006514603.1 interleukin-9 receptor isoform X7

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:140 → 247

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006514534.4 → XP_006514597.1 interleukin-9 receptor isoform X2

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:254 → 360

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006514533.4 → XP_006514596.1 interleukin-9 receptor isoform X1

UniProtKB/TrEMBL

B7ZD65

Conserved Domains (1) summary

cd00063
Location:254 → 361

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...