Inhbb inhibin beta-B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inhbbprovided by MGI
Official Full Name: inhibin beta-Bprovided by MGI
Primary source: MGI:MGI:96571
See related: Ensembl:ENSMUSG00000037035 AllianceGenome:MGI:96571
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Homozygous knockout mice for this gene exhibit eyelid defects. [provided by RefSeq, Aug 2016]
Expression: Biased expression in ovary adult (RPKM 148.1), mammary gland adult (RPKM 18.2) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.29 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (119343193..119349978, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (119415463..119422248, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.
Title: Human INHBB Gene Variant (c.1079T>C:p.Met360Thr) Alters Testis Germ Cell Content, but Does Not Impact Fertility in Mice.
Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis.
Title: Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis.
These data suggest that activin-follistatin regulation may play a role during the development of Experimental autoimmune epididymo-orchitis.
Title: Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.
Inflammatory stimuli strongly induce Smad2 and Smad5 phosphorylation in wild-type mice. None of these Smad effectors are activated in mice deficient in activin B. Activin B, whose messenger RNA expression is strongly induced after LPS administration or E coli infection, is required for activation of Smad1/5/8 signaling. Hepcidin expression did not depend on activin B expression.
Title: Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B.
These results suggest that prolonged exposure to hyperglycemia in the Ins2(Akita+/-) mice leads to progressive testicular disruption mediated by testicular activin activity, rather than hormonal dysregulation.
Title: Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2(Akita+/-) mouse model of type 1 diabetes.
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3, as a model of immature Leydig cells.
Title: Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.
Menin binds on the promoter of Inhbb gene where it favours the recruitment of Ezh2 via an indirect mechanism involving Akt-phosphorylation.
Title: Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.
Data suggest Inhbb is physiologically essential for early folliculogenesis; Inhbb appears to participate in regulation of cell cycle progression, apoptosis, and steroidogenesis (estradiol/progesterone synthesis) in ovarian granulosa cells in culture.
Title: RNAi-mediated knockdown of INHBB increases apoptosis and inhibits steroidogenesis in mouse granulosa cells.
Activin B, a transforming growth factor beta - related ligand, is upregulated during tumorigenesis and drives the loss of insulin expression and beta-cell maturity in a mouse insulinoma model.
Title: ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation.
in mammalian spinal cord, Tgfbeta ligands and ActB together support oligodendrocyte development and myelin formation
Title: Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC203309P3 (e-PCR)
- UniSTS:271900

d13mgh16 (e-PCR)
- UniSTS:120868

Inhbb (e-PCR), detects polymorphism
- UniSTS:496692

PMC155220P1 (e-PCR)
- UniSTS:271333

Inhbb (e-PCR), detects polymorphism
- UniSTS:143590

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to leptin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in eye development	TAS Traceable Author Statement more info	PubMed
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oocyte development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of follicle-stimulating hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inhibin beta B chain

Names: activin beta-B chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.