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eif-3.I Eukaryotic translation initiation factor 3 subunit I;WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 171809, updated on 23-Nov-2023

Summary

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Gene symbol
eif-3.I
Gene description
Eukaryotic translation initiation factor 3 subunit I;WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00001232
Locus tag
CELE_Y74C10AR.1
See related
AllianceGenome:WB:WBGene00001232
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex, eIF3m. Orthologous to human EIF3I (eukaryotic translation initiation factor 3 subunit I). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
4
Sequence:
Chromosome: I; NC_003279.8 (2485861..2489787)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 50A Neighboring gene ABC transmembrane type-1 domain-containing protein Neighboring gene Conserved secreted protein Neighboring gene ATP-dependent RNA helicase;DUF4217 domain-containing protein Neighboring gene U3 small nucleolar RNA-associated protein 15 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function. Giles AC, et al. J Biol Chem, 2019 Apr 26. PMID 30858176, Free PMC Article
  2. Functional characterization of C. elegans Y-box-binding proteins reveals tissue-specific functions and a critical role in the formation of polysomes. Arnold A, et al. Nucleic Acids Res, 2014 Dec 1. PMID 25378320, Free PMC Article
  3. Mechanism and regulation of translation in C. elegans. Rhoads RE, et al. WormBook, 2006 Jan 28. PMID 18050488, Free PMC Article
  4. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article
  5. ABCE1 is a highly conserved RNA silencing suppressor. Kärblane K, et al. PLoS One, 2015. PMID 25659154, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translational initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in formation of cytoplasmic translation initiation complex IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Eukaryotic translation initiation factor 3 subunit I;WD_REPEATS_REGION domain-containing protein
NP_001293284.1
  • Confirmed by transcript evidence
NP_490988.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    2485861..2489787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058587.6 → NP_490988.2  Eukaryotic translation initiation factor 3 subunit I [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490988.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q965S8
    Conserved Domains (3) summary
    COG2319
    Location:5 → 313
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:14 → 50
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:6 → 313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001306355.3 → NP_001293284.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061ADR6
    Conserved Domains (2) summary
    smart00320
    Location:24 → 59
    WD40; WD40 repeats
    sd00039
    Location:36 → 62
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q965S8.2

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