rpn-8 MPN domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: rpn-8
Gene description: MPN domain-containing protein
Primary source: WormBase:WBGene00004464
Locus tag: CELE_R12E2.3
See related: AllianceGenome:WB:WBGene00004464
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable isopeptidase activity and metallopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. Is expressed in several structures, including enteric muscle; excretory cell; intestine; nervous system; and reproductive system. Orthologous to human PSMD7 (proteasome 26S subunit, non-ATPase 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: I

Exon count:: 7

Sequence:: Chromosome: I; NC_003279.8 (4175319..4177271)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R12E2.12 (e-PCR)
- UniSTS:306710

R12E2.3 (e-PCR)
- UniSTS:305876

STS1-138 (e-PCR)
- UniSTS:241624

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of proteasome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MPN domain-containing protein

NP_491319.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4175319..4177271

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058918.8 → NP_491319.1 MPN domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491319.1

Status: REVIEWED

UniProtKB/TrEMBL

O61792

Conserved Domains (1) summary

cd08062
Location:39 → 320

MPN_RPN7_8; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8