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Mc4r melanocortin 4 receptor [ Mus musculus (house mouse) ]

Gene ID: 17202, updated on 16-Apr-2024

Summary

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Official Symbol
Mc4rprovided by MGI
Official Full Name
melanocortin 4 receptorprovided by MGI
Primary source
MGI:MGI:99457
See related
Ensembl:ENSMUSG00000047259 AllianceGenome:MGI:99457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkcp; Mc4-r
Summary
This gene encodes a member of the melanocortin receptor family. Melanocortin receptors are transmembrane G-protein coupled receptors, which respond to small peptide hormones and exhibit diverse functions and tissue type localization. As part of the central nervous melanocortin system, the encoded protein is competitively bound by either melanocyte stimulating hormone or agouti-related protein to regulate energy homeostasis. Disruption of this gene promotes hyperphagia and obesity, and is associated with increased cholesterol levels and insulin resistance. [provided by RefSeq, Dec 2012]
Orthologs
human all
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Genomic context

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See Mc4r in Genome Data Viewer
Location:
18 E1; 18 39.72 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (66990776..66993558, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (66857705..66860487, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41762 Neighboring gene predicted gene, 22219 Neighboring gene predicted gene, 30190 Neighboring gene STARR-seq mESC enhancer starr_44866 Neighboring gene STARR-seq mESC enhancer starr_44867 Neighboring gene STARR-seq mESC enhancer starr_44868 Neighboring gene predicted gene, 19784 Neighboring gene STARR-seq mESC enhancer starr_44869 Neighboring gene predicted gene, 57656

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation. Singh U, et al. Physiol Behav, 2023 Apr 1. PMID 36736416, Free PMC Article
  2. MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity. Wang X, et al. Diabetes, 2022 Nov 1. PMID 35926095
  3. Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue. Morita S, et al. Sci Rep, 2022 Jun 16. PMID 35710868, Free PMC Article
  4. Melanocortin MC(4)R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Oliveira V, et al. Physiol Genomics, 2022 Jun 1. PMID 35476598, Free PMC Article
  5. Stimulation of G(s) signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice. Matsumura S, et al. Am J Physiol Endocrinol Metab, 2022 May 1. PMID 35344393

See all (278) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.
    Title: Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1.
  2. A human obesity-associated MC4R mutation with defective Gq/11alpha signaling leads to hyperphagia in mice.
    Title: A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice.
  3. Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.
    Title: Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R.
  4. Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
    Title: Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.
  5. Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.
    Title: Melanocortin 4 receptor signaling in Sim1 neurons permits sexual receptivity in female mice.
  6. Glutamatergic melanocortin-4 receptor neurons regulate body weight.
    Title: Glutamatergic melanocortin-4 receptor neurons regulate body weight.
  7. Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.
    Title: Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice.
  8. Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.
    Title: Collateralizing ventral subiculum melanocortin 4 receptor circuits regulate energy balance and food motivation.
  9. Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and beta-arrestin-1 Pathways.
    Title: Islet MC4R Regulates PC1/3 to Improve Insulin Secretion in T2DM Mice via the cAMP and β-arrestin-1 Pathways.
  10. MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity.
    Title: MC4R Deficiency Causes Dysregulation of Postsynaptic Excitatory Synaptic Transmission as a Crucial Culprit for Obesity.
Submit: New GeneRIF Correction See all GeneRIFs (119)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables melanocortin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables melanocortin receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables melanocyte-stimulating hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables melanocyte-stimulating hormone receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables melanocyte-stimulating hormone receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in diet induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in feeding behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within insulin secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of eating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of grooming behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to melanocyte-stimulating hormone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
melanocortin receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016977.4 → NP_058673.2  melanocortin receptor 4

    See identical proteins and their annotated locations for NP_058673.2

    Status: REVIEWED

    Source sequence(s)
    AK136793, BB633776, BY646801
    Consensus CDS
    CCDS29316.1
    UniProtKB/Swiss-Prot
    P56450, Q49NR4, Q9EQM7
    UniProtKB/TrEMBL
    Q49NR1
    Related
    ENSMUSP00000054776.3, ENSMUST00000057942.4
    Conserved Domains (1) summary
    cd15353
    Location:45 → 313
    7tmA_MC4R; melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    66990776..66993558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56450.3 GenPept UniProtKB/Swiss-Prot:P56450

Gene LinkOut

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Chemical Information
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