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pdp-1 PPM-type phosphatase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 172035, updated on 23-Nov-2023

Summary

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Gene symbol
pdp-1
Gene description
PPM-type phosphatase domain-containing protein
Primary source
WormBase:WBGene00022832
Locus tag
CELE_ZK973.3
See related
AllianceGenome:WB:WBGene00022832
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable [pyruvate dehydrogenase (lipoamide)] phosphatase activity. Predicted to be involved in positive regulation of pyruvate dehydrogenase activity and protein dephosphorylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in obesity and pyruvate decarboxylase deficiency. Orthologous to human PDP1 (pyruvate dehydrogenase phosphatase catalytic subunit 1) and PDP2 (pyruvate dehyrogenase phosphatase catalytic subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See pdp-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
5
Sequence:
Chromosome: I; NC_003279.8 (4368089..4370463)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene BTB domain-containing protein Neighboring gene SS18 N-terminal domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Neighboring gene Chromo domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ketone bodies mimic the life span extending properties of caloric restriction. Veech RL, et al. IUBMB Life, 2017 May. PMID 28371201
  2. PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism. Narasimhan SD, et al. PLoS Genet, 2011 Apr. PMID 21533078, Free PMC Article
  3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PDP-1 modulates the expression of several insulin genes that are likely to feed into the IIS pathway to regulate DAF-16 activity.
    Title: PDP-1 links the TGF-β and IIS pathways to regulate longevity, development, and metabolism.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PPM-type phosphatase domain-containing protein
NP_491357.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    4368089..4370463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058956.8 → NP_491357.1  PPM-type phosphatase domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_491357.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9N4M0
    Conserved Domains (1) summary
    cd00143
    Location:43 → 438
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
Nucleotide Protein
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